Zobrazeno 1 - 10
of 410
pro vyhledávání: '"Mark A. Ross"'
Autor:
Jessica N. Filderman, Jennifer L. Taylor, Jianmin Wang, Yali Zhang, Prashant Singh, Mark A. Ross, Simon C. Watkins, Ayah Nedal Al Bzour, Lilit Karapetyan, Pawel Kalinski, Walter J. Storkus
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundStimulator of Interferon Genes (STING) is a dsDNA sensor that triggers type I inflammatory responses. Recent data from our group and others support the therapeutic efficacy of STING agonists applied intratumorally or systemically in a range
Externí odkaz:
https://doaj.org/article/3c0638960d42499caddb87b687f3e945
Autor:
Cindy A. Sander, Elizabeth A. Rush, Jian Shi, Lidia M. R. B. Arantes, Raymond J. Tesi, Mark A. Ross, Michael J. Calderon, Simon C. Watkins, John M. Kirkwood, Robert L. Ferris, Lisa H. Butterfield, Lazar Vujanovic
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background The effectiveness of MAPK pathway inhibitors (MAPKi) used to treat patients with BRAF-mutant melanoma is limited by a range of resistance mechanisms, including soluble TNF (solTNF)-mediated NF-kB signaling. solTNF preferentially s
Externí odkaz:
https://doaj.org/article/7e128c7aab314546b0925e5c93471c76
Autor:
Adolf Koudelka, Veronika Cechova, Mauricio Rojas, Nilay Mitash, Anna Bondonese, Claudette St. Croix, Mark A. Ross, Bruce A. Freeman
Publikováno v:
Redox Biology, Vol 50, Iss , Pp 102226- (2022)
Tissue fibrosis occurs in response to dysregulated metabolism, pro-inflammatory signaling and tissue repair reactions. For example, lungs exposed to environmental toxins, cancer therapies, chronic inflammation and other stimuli manifest a phenotypic
Externí odkaz:
https://doaj.org/article/35581b9bda244c64a72292eaba451e09
Autor:
Andria R. Robinson, Matthew J. Yousefzadeh, Tania A. Rozgaja, Jin Wang, Xuesen Li, Jeremy S. Tilstra, Chelsea H. Feldman, Siobhán Q. Gregg, Caroline H. Johnson, Erin M. Skoda, Marie-Céline Frantz, Harris Bell-Temin, Hannah Pope-Varsalona, Aditi U. Gurkar, Luigi A. Nasto, Renã A.S. Robinson, Heike Fuhrmann-Stroissnigg, Jolanta Czerwinska, Sara J. McGowan, Nadiezhda Cantu-Medellin, Jamie B. Harris, Salony Maniar, Mark A. Ross, Christy E. Trussoni, Nicholas F. LaRusso, Eugenia Cifuentes-Pagano, Patrick J. Pagano, Barbara Tudek, Nam V. Vo, Lora H. Rigatti, Patricia L. Opresko, Donna B. Stolz, Simon C. Watkins, Christin E. Burd, Claudette M. St. Croix, Gary Siuzdak, Nathan A. Yates, Paul D. Robbins, Yinsheng Wang, Peter Wipf, Eric E. Kelley, Laura J. Niedernhofer
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 259-273 (2018)
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate se
Externí odkaz:
https://doaj.org/article/d9a5a11c481f443f90c56186ddad5c93
Autor:
Brian A. Boone, Pranav Murthy, Jennifer Miller-Ocuin, W. Reed Doerfler, Jarrod T. Ellis, Xiaoyan Liang, Mark A. Ross, Callen T. Wallace, Jason L. Sperry, Michael T. Lotze, Matthew D. Neal, Herbert J. Zeh
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background The hypercoagulable state associated with pancreatic adenocarcinoma (PDA) results in increased risk of venous thromboembolism, leading to substantial morbidity and mortality. Recently, neutrophil extracellular traps (NETs), whereb
Externí odkaz:
https://doaj.org/article/7bb851ee267642998fc7ef74c6f8bd4d
Autor:
Pranav Murthy, Aatur D. Singhi, Mark A. Ross, Patricia Loughran, Pedram Paragomi, Georgios I. Papachristou, David C. Whitcomb, Amer H. Zureikat, Michael T. Lotze, Herbert J. Zeh III, Brian A. Boone
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Neutrophil extracellular traps (NETs) are generated when activated neutrophils, driven by PAD4, release their DNA, histones, HMGB1, and other intracellular granule components. NETs play a role in acute pancreatitis, worsening pancreatic i
Externí odkaz:
https://doaj.org/article/2f246b1f618e4df2a01e34b810a99c8b
Autor:
Kedar Ghimire, Yao Li, Takuto Chiba, Sohel M. Julovi, Jennifer Li, Mark A. Ross, Adam C. Straub, Philip J. O’Connell, Curzio Rüegg, Patrick J. Pagano, Jeffrey S. Isenberg, Natasha M. Rogers
Publikováno v:
Cells, Vol 9, Iss 7, p 1695 (2020)
The aged population is currently at its highest level in human history and is expected to increase further in the coming years. In humans, aging is accompanied by impaired angiogenesis, diminished blood flow and altered metabolism, among others. A ce
Externí odkaz:
https://doaj.org/article/2d0ec60913d84b10af7b3205477de3d8
Publikováno v:
Tremor and Other Hyperkinetic Movements, Vol 6 (2016)
No abstract necessary for Letters.
Externí odkaz:
https://doaj.org/article/aa31a0b2c99348db8cbb672d71dbf149
Publikováno v:
Frontiers in Neurology, Vol 7 (2016)
Externí odkaz:
https://doaj.org/article/9346f2aa928f498aaa1f36788caa857a
Autor:
Sarra L. Ryan, John F. Peden, Zoya Kingsbury, Claire J. Schwab, Terena James, Petri Polonen, Martina Mijuskovic, Jenn Becq, Richard Yim, Ruth E. Cranston, Dale J. Hedges, Kathryn G. Roberts, Charles G. Mullighan, Ajay Vora, Lisa J. Russell, Robert Bain, Anthony V. Moorman, David R. Bentley, Christine J. Harrison, Mark T. Ross
Publikováno v:
Leukemia. 37:518-528
Childhood B-cell acute lymphoblastic leukaemia (B-ALL) is characterised by recurrent genetic abnormalities that drive risk-directed treatment strategies. Using current techniques, accurate detection of such aberrations can be challenging, due to the