Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Mark A. Rider"'
Publikováno v:
Journal of Extracellular Vesicles, Vol 5, Iss 0, Pp 1-20 (2016)
Background: Extracellular vesicles (EVs) are important mediators of cell-to-cell communication in healthy and pathological environments. Because EVs are present in a variety of biological fluids and contain molecular signatures of their cell or tissu
Externí odkaz:
https://doaj.org/article/edef521f3d7041808c3005fa35071abc
Autor:
Nathalie Kyalu Ngoie Zola, Clémence Balty, Sébastien Pyr dit Ruys, Axelle A. T. Vanparys, Nicolas D. G. Huyghe, Gaëtan Herinckx, Manuel Johanns, Emilien Boyer, Pascal Kienlen-Campard, Mark H. Rider, Didier Vertommen, Bernard J. Hanseeuw
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Tau protein aggregates in several neurodegenerative disorders, referred to as tauopathies. The tau isoforms observed in post mortem human brain aggregates is used to classify tauopathies. However, distinguishing tauopathies ante mortem remai
Externí odkaz:
https://doaj.org/article/4e8b82b43d3a464a834a3b43efbae384
Publikováno v:
Biochemical Journal. 480:105-125
Is there a role for AMPK in the control of hepatic gluconeogenesis and could targeting AMPK in liver be a viable strategy for treating type 2 diabetes? These are frequently asked questions this review tries to answer. After describing properties of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f2c871380064e8082cdbeeb9cf09494
https://doi.org/10.1042/bcj20220582
https://doi.org/10.1042/bcj20220582
Autor:
Manuel Johanns, Cyril Corbet, Roxane Jacobs, Melissa Drappier, Guido T. Bommer, Gaëtan Herinckx, Didier Vertommen, Nicolas Tajeddine, David Young, Joris Messens, Olivier Feron, Gregory R. Steinberg, Louis Hue, Mark H. Rider
Publikováno v:
The Biochemical journal, Vol. 479, no.12, p. 1317-1336 (2022)
Pharmacological AMPK activation represents an attractive approach for the treatment of type 2 diabetes (T2D). AMPK activation increases skeletal muscle glucose uptake, but there is controversy as to whether AMPK activation also inhibits hepatic gluco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aac092c3c348fbc7d9f09e908c72f48
https://doi.org/10.1042/bcj20220170
https://doi.org/10.1042/bcj20220170
Autor:
Benoit Viollet, Sébastien Pyr dit Ruys, Gregory R. Steinberg, Bruce E. Kemp, Mark H. Rider, Sheng-Ju Chuang, Manuel Johanns
Publikováno v:
The Biochemical journal, Vol. 478, no.21, p. 3869-3889 (2021)
The effects of small-molecule AMP-activated protein kinase (AMPK) activators in rat epididymal adipocytes were compared. SC4 was the most effective and submaximal doses of SC4 and 5-amino-4-imidazolecarboxamide (AICA) riboside were combined to study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eba523dbceb443a0c1800973c66789e
https://doi.org/10.1042/bcj20210411
https://doi.org/10.1042/bcj20210411
Autor:
Gregory R. Steinberg, Bruce E. Kemp, Sheng-Ju Chuang, Nusrat Hussain, Mark H. Rider, Manuel Johanns, Didier Vertommen
Publikováno v:
The Biochemical journal, Vol. 477, no. 8, p. 1373-1389 (2020)
We investigated acute effects of two allosteric protein kinase B (PKB) inhibitors, MK-2206 and Akti-1/2, on insulin-stimulated lipogenesis in rat epididymal adipocytes incubated with fructose as carbohydrate substrate. In parallel, the phosphorylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59727fb918211c837ae44dcc545ea2b7
https://doi.org/10.1042/bcj20190788
https://doi.org/10.1042/bcj20190788
Autor:
Nusrat Hussain, Sheng-Ju Chuang, Manuel Johanns, Didier Vertommen, Gregory R. Steinberg, Bruce E. Kemp, Mark H. Rider
Publikováno v:
The Biochemical journal, Vol. 477, no.23, p. 4599-4601 (2020)
This is a correction to: Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue. Biochem J (2020) 477 (8): 1373–1389 https://doi.org/10.1042/BCJ20190788
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b75516263b43147d2d739c196c390e
https://doi.org/10.1042/bcj-2019-0788_cor
https://doi.org/10.1042/bcj-2019-0788_cor
Autor:
Didier Vertommen, Manuel Johanns, Gregory R. Steinberg, Cyril Corbet, Mark H. Rider, Marie-France Herent, Olivier Feron, Claire Beaufay, Vincent Stroobant, Aphrodite T. Choumessi, Roxane Jacobs, Joëlle Quetin-Leclercq, Gaëtan Herinckx
Publikováno v:
Biochemical Journal, Vol. 476, no. 24, p. 3687-3704 (2019)
Root extracts of a Cameroon medicinal plant, Dorstenia psilurus, were purified by screening for AMP-activated protein kinase (AMPK) activation in incubated mouse embryo fibroblasts (MEFs). Two isoprenylated flavones that activated AMPK were isolated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bae3de770bcc3108ac9acf77795891
https://doi.org/10.1042/bcj20190326
https://doi.org/10.1042/bcj20190326
Autor:
Guido T. Bommer, Isabelle Gerin, Maria Veiga-da-Cunha, Mark H. Rider, Joseph P. Dewulf, Emile Van Schaftingen
Publikováno v:
Biochemical Journal
The Biochemical journal, Vol. 476, no. 16, p. 2427-2447 (2019)
The Biochemical journal, Vol. 476, no. 16, p. 2427-2447 (2019)
Most fatty acids (FAs) are straight chains and are synthesized by fatty acid synthase (FASN) using acetyl-CoA and malonyl-CoA units. Yet, FASN is known to be promiscuous as it may use methylmalonyl-CoA instead of malonyl-CoA and thereby introduce met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b04f64548f63bda73e0b47bba8c527d
https://doi.org/10.1042/bcj20190500
https://doi.org/10.1042/bcj20190500
Autor:
Sébastien Pyr dit Ruys, Bernard Hanseeuw, Didier Vertommen, Gaëtan Herinckx, Mark H. Rider, Nathalie Kyalu Ngoie Zola
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b4e2ff468ac81e60951bb76e37c95e0
https://doi.org/10.1002/alz.047557
https://doi.org/10.1002/alz.047557