Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mark A. Metcalf"'
Autor:
Bryan L. Roth, Mark A. Metcalf, Naseem Khan, Teresa Druck, Herbert Y. Meltzer, Mark W. Hamblin, Ruth Kohen, Kay Huebner, Jean E. Lachowicz, David R. Sibley
Publikováno v:
Journal of Neurochemistry. 66:47-56
We describe the cloning and characterization of a human 5-HT6 serotonin receptor. The open reading frame is interrupted by two introns in positions corresponding to the third cytoplasmic loop and the third extracellular loop. The human 5-HT6 cDNA enc
The interaction of Belousov-Zhabotinsky and Fisher-Kolmogorov waves across a semi-permeable membrane
Publikováno v:
Proceedings of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences. 452:1807-1826
The propagation of chemical waves in two regions, coupled together by a linear diffusive interchange of neutral species across a semi-permeable membrane is considered. The reaction scheme in region I is assumed to have Belousov-Zhabotinsky kinetics a
Autor:
Yong Shen, Pedro A. Jose, David R. Sibley, Mark W. Hamblin, Frederick J. Monsma, Mark A. Metcalf
Publikováno v:
Journal of Biological Chemistry. 268:18200-18204
We have utilized the polymerase chain reaction technique to selectively amplify a G protein-coupled receptor cDNA from rat kidney proximal convoluted tubule mRNA, which exhibits high homology with previously cloned serotonin receptors. Sequencing of
Publikováno v:
Biochemical Pharmacology. 44:1917-1920
The human 5-HT 1Ds serotonin receptor and its rat homolog (also called the 5-HT 1B receptor) share 93% amino acid identity, yet display markedly different pharmacological specificities. Comparison of deduced amino acid sequences among these and other
Publikováno v:
Biochemical and Biophysical Research Communications. 184:752-759
We describe a genomic clone encoding the human 5-HT1B receptor. This apparently intronless gene encodes a 390 amino acid polypeptide homologous to the rat 5-HT1B serotonin receptor, with which it shares 93% amino acid sequence identity. Remarkably, [
Publikováno v:
Journal of virology. 84(1)
It was shown previously that the highly conserved vaccinia virus A35 gene is an important virulence factor in respiratory infection of mice. We show here that A35 is also required for full virulence by the intraperitoneal route of infection. A virus
Autor:
Mark D. Nielsen, Soren Impey, Daniel R. Storm, Lauren P. Baker, Steven W. Poser, Karl Obrietan, Mark A. Metcalf, Guy C.-K. Chan, Mark W. Hamblin
Publikováno v:
The Journal of biological chemistry. 273(28)
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) plays an important regulatory role in developing and adult nervous systems. With the exception of the 5-HT3 receptor, all of the cloned serotonin receptors belong to the G protein-coupled rec
Publikováno v:
Journal of neurochemistry. 68(4)
The serotonin (5-HT) 5-HT7 receptor subtype is thought to mediate a number of physiological effects in mammalian brain and periphery. Previous studies suggested that alternative splicing might contribute to 5-HT7 receptor diversity as well. We now re
Publikováno v:
Molecular and cellular neurosciences. 3(6)
We and others have recently cloned the genes encoding the human 5-HT(1D) (5-HT(1Dalpha)) and 5-HT(1B) (5-HT(1Dbeta)) serotonin receptors. Because of the history of profound species differences in the pharmacology of these receptor subtypes, we also c