Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Mark A. McCoy"'
Autor:
Mark A. McCoy, Jun Lu, F. Richard Miller, Stephen M. Soisson, Michael H. Lam, Christian Fischer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract We report bio-structural, bio-chemical and bio-physical evidence demonstrating how small molecules can bind to both wild-type and mutant IDH1, but only inhibit the enzymatic activity of the mutant isoform. Enabled through x-ray crystallograp
Externí odkaz:
https://doaj.org/article/1f1e81c5eb924dc0bbef06cb6013bd24
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Multispecific therapeutic proteins come in a variety of formats, including bi- and tri-specific antibodies, dual-variable domain antibodies, and CrossMabs. These multivalent proteins are engineered to interact with multiple therapeutic target protein
Externí odkaz:
https://doaj.org/article/4fcb4e63df00416eaca1675b22f3f367
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Biotherapeutics are an important class of molecules for the treatment of a wide range of diseases. They include low molecular weight peptides, highly engineered protein scaffolds and monoclonal antibodies. During their discovery and development, asse
Externí odkaz:
https://doaj.org/article/997c00f3564e43a68d6394f92c31779a
Autor:
Qiyi He, Mark R. McCoy, Huiyi Yang, Mingxia Lin, Xiping Cui, Suqing Zhao, Christophe Morisseau, Dongyang Li, Bruce D. Hammock
Publikováno v:
Analytical Chemistry. 95:6038-6045
Autor:
Caitlan M. V. Butler, Christopher M. Stevenson, Mark D. McCoy, Alex Jorgensen, Thegn N. Ladefoged
Publikováno v:
The Journal of Island and Coastal Archaeology. :1-21
Autor:
Qiyi, He, Li, Yang, Mingxia, Lin, Huiyi, Yang, Xiping, Cui, Mark R, McCoy, Bruce D, Hammock, Yanxiong, Fang, Suqing, Zhao
Publikováno v:
Analytical and Bioanalytical Chemistry. 414:6939-6946
Ferritin, widely present in liver and spleen tissue, is considered as a serological biomarker for liver diseases and cancers. The detection of ferritin may be an important tool in health diagnosis. In this study, 14 non-immunized chicken spleens were
Autor:
David Roush, Michael Iammarino, Rebecca Chmielowski, Francis Insaidoo, Mark A. McCoy, Allison Ortigosa, Michael Rauscher
Publikováno v:
Biotechnology and Bioengineering.
Publikováno v:
American Antiquity. 87:591-600
Identifying and explaining the end of long-lived practices is a major challenge for anthropological archaeology. We present a high-precision uranium series dating (230Th/U) chronology of an undocumented aspect of Hawaiian religion: the use of corals
Autor:
Dmitri A. Pissarnitski, Ahmet Kekec, Lin Yan, Yuping Zhu, Danqing D. Feng, Pei Huo, Christina Madsen-Duggan, Christopher R. Moyes, Ravi P. Nargund, Terri Kelly, Xiaoping Zhang, Ester Carballo-Jane, Judith Gorski, Peter Zafian, Mo Qatanani, Niels Kaarsholm, Fanyu Meng, Xiujuan Jia, Keun-Joong Lee, Weixun Wang, Sherrie Xu, Michael J. Hohn, Michael J. Iammarino, Mark A. McCoy, Grace A. Okoh, Yingkai Liang, Scott A. Hollingsworth, Mark D. Erion, David E. Kelley, Robert M. Garbaccio, Amy Zhang, James Mu, Songnian Lin
Publikováno v:
Journal of Medicinal Chemistry. 65:5593-5605
We have identified a series of novel insulin receptor partial agonists (IRPAs) with a potential to mitigate the risk of hypoglycemia associated with the use of insulin as an antidiabetic treatment. These molecules were designed as dimers of native in
Publikováno v:
Journal of the Polynesian Society. 131:71-92
At present there is no systematic record of the size, form or density of architecture at Hawaiian royal centres. We report on the results of a UAV LiDAR survey of one of the best-preserved examples of a royal centre in the archipelago: Hōlualoa Roya