Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Mark A. Magnuson"'
Autor:
Mark A. Magnuson, Anna B. Osipovich
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Early in the development of Type 2 diabetes (T2D), metabolic stress brought on by insulin resistance and nutrient overload causes β-cell hyperstimulation. Herein we summarize recent studies that have explored the premise that an increase in the intr
Externí odkaz:
https://doaj.org/article/4e7ff2126f354766aee0e9a2e539acda
Autor:
Anna B. Osipovich, Frank Y. Zhou, Judy J. Chong, Linh T. Trinh, Mathew A. Cottam, Shristi Shrestha, Jean-Philippe Cartailler, Mark A. Magnuson
Publikováno v:
Molecular Metabolism, Vol 78, Iss , Pp 101811- (2023)
Objective: ASCL1, a pioneer transcription factor, is essential for neural cell differentiation and function. Previous studies have shown that Ascl1 expression is increased in pancreatic β-cells lacking functional KATP channels or after feeding of a
Externí odkaz:
https://doaj.org/article/c960991850aa4a3a86d2b2985abf0881
Autor:
Jeeyeon Cha, Xin Tong, Emily M. Walker, Tehila Dahan, Veronica A. Cochrane, Sudipta Ashe, Ronan Russell, Anna B. Osipovich, Alex M. Mawla, Min Guo, Jin-hua Liu, Zachary A. Loyd, Mark O. Huising, Mark A. Magnuson, Matthias Hebrok, Yuval Dor, Roland Stein
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Type 2 diabetes (T2D) is associated with compromised identity of insulin-producing pancreatic islet β cells, characterized by inappropriate production of other islet cell–enriched hormones. Here, we examined how hormone misexpression was influence
Externí odkaz:
https://doaj.org/article/d8557c8689a94c42a21473f2861b2627
Autor:
Kung-Hsien Ho, Anissa Jayathilake, Yagan Mahircan, Aisha Nour, Anna B. Osipovich, Mark A. Magnuson, Guoqiang Gu, Irina Kaverina
Publikováno v:
iScience, Vol 26, Iss 2, Pp 105938- (2023)
Summary: Glucose stimulation induces the remodeling of microtubules, which potentiates insulin secretion in pancreatic β-cells. CAMSAP2 binds to microtubule minus ends to stabilize microtubules in several cultured clonal cells. Here, we report that
Externí odkaz:
https://doaj.org/article/fcefcd0718854146891e21c7a8ebb26a
Autor:
Linh T. Trinh, Anna B. Osipovich, Leesa Sampson, Jonathan Wong, Chris V.E. Wright, Mark A. Magnuson
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104905- (2022)
Summary: Sox17 gene expression is essential for both endothelial and endodermal cell differentiation. To better understand the genetic basis for the expression of multiple Sox17 mRNA forms, we identified and performed CRISPR/Cas9 mutagenesis of two e
Externí odkaz:
https://doaj.org/article/a59f4090bd5640709f0bf2d8fef60857
Autor:
Tiziana Sanavia, Chen Huang, Elisabetta Manduchi, Yanwen Xu, Prasanna K. Dadi, Leah A. Potter, David A. Jacobson, Barbara Di Camillo, Mark A. Magnuson, Christian J. Stoeckert, Guoqiang Gu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Newly differentiated pancreatic β cells lack proper insulin secretion profiles of mature functional β cells. The global gene expression differences between paired immature and mature β cells have been studied, but the dynamics of transcriptional e
Externí odkaz:
https://doaj.org/article/47b8caae6e74492aa21b7970e51d0e96
Autor:
Hui-Ju Wen, Shan Gao, Yin Wang, Michael Ray, Mark A. Magnuson, Christopher V.E. Wright, Marina Pasca Di Magliano, Timothy L. Frankel, Howard C. Crawford
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 2, Pp 173-192 (2019)
Background & Aims: Pancreatitis is a major cause of morbidity and mortality and is a risk factor for pancreatic tumorigenesis. Upon tissue damage, an inflammatory response, made up largely of macrophages, provides multiple growth factors that promote
Externí odkaz:
https://doaj.org/article/0bcf60c741024912b043544219441d02
Autor:
Tomoyuki Fujiyama, Satoshi Miyashita, Yousuke Tsuneoka, Kazumasa Kanemaru, Miyo Kakizaki, Satomi Kanno, Yukiko Ishikawa, Mariko Yamashita, Tomoo Owa, Mai Nagaoka, Yoshiya Kawaguchi, Yuchio Yanagawa, Mark A. Magnuson, Masafumi Muratani, Akira Shibuya, Yo-ichi Nabeshima, Masashi Yanagisawa, Hiromasa Funato, Mikio Hoshino
Publikováno v:
Cell Reports, Vol 24, Iss 1, Pp 79-94 (2018)
Summary: The mammalian brain undergoes sexual differentiation by gonadal hormones during the perinatal critical period. However, the machinery at earlier stages has not been well studied. We found that Ptf1a is expressed in certain neuroepithelial ce
Externí odkaz:
https://doaj.org/article/43014b83a29b42378d8a195013100f79
Autor:
Clayton B. Marshall, Deborah J. Mays, J. Scott Beeler, Jennifer M. Rosenbluth, Kelli L. Boyd, Gabriela L. Santos Guasch, Timothy M. Shaver, Lucy J. Tang, Qi Liu, Yu Shyr, Bryan J. Venters, Mark A. Magnuson, Jennifer A. Pietenpol
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2289-2300 (2016)
We report that p73 is expressed in multiciliated cells (MCCs), is required for MCC differentiation, and directly regulates transcriptional modulators of multiciliogenesis. Loss of ciliary biogenesis provides a unifying mechanism for many phenotypes o
Externí odkaz:
https://doaj.org/article/60e7056b5c994e80bcb344c1e1c7bb07
Autor:
Hung Ping Shih, Philip A. Seymour, Nisha A. Patel, Ruiyu Xie, Allen Wang, Patrick P. Liu, Gene W. Yeo, Mark A. Magnuson, Maike Sander
Publikováno v:
Cell Reports, Vol 13, Iss 2, Pp 326-336 (2015)
The generation of pancreas, liver, and intestine from a common pool of progenitors in the foregut endoderm requires the establishment of organ boundaries. How dorsal foregut progenitors activate pancreatic genes and evade the intestinal lineage choic
Externí odkaz:
https://doaj.org/article/2f846faee2cb467b9d1d7453dc06e4f4