Zobrazeno 1 - 10
of 388
pro vyhledávání: '"Mark A. Lemmon"'
Autor:
Joann Chongsaritsinsuk, Alexandra D. Steigmeyer, Keira E. Mahoney, Mia A. Rosenfeld, Taryn M. Lucas, Courtney M. Smith, Alice Li, Deniz Ince, Fiona L. Kearns, Alexandria S. Battison, Marie A. Hollenhorst, D. Judy Shon, Katherine H. Tiemeyer, Victor Attah, Catherine Kwon, Carolyn R. Bertozzi, Michael J. Ferracane, Mark A. Lemmon, Rommie E. Amaro, Stacy A. Malaker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of biological functions. In particular, the T cell immunoglobulin and mucin-domain containing family of proteins (TIM-1, -3, -4) decorate immune cells an
Externí odkaz:
https://doaj.org/article/c4f9c600267c4d6cb125292d69f93726
Autor:
Esther R. Berko, Gabriela M. Witek, Smita Matkar, Zaritza O. Petrova, Megan A. Wu, Courtney M. Smith, Alex Daniels, Joshua Kalna, Annie Kennedy, Ivan Gostuski, Colleen Casey, Kateryna Krytska, Mark Gerelus, Dean Pavlick, Susan Ghazarian, Julie R. Park, Araz Marachelian, John M. Maris, Kelly C. Goldsmith, Ravi Radhakrishnan, Mark A. Lemmon, Yaël P. Mossé
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Activating point mutations in Anaplastic Lymphoma Kinase (ALK) have positioned ALK as the only mutated oncogene tractable for targeted therapy in neuroblastoma. Cells with these mutations respond to lorlatinib in pre-clinical studies, provid
Externí odkaz:
https://doaj.org/article/c0e4bcb6136d4cc7a5072df22f3d7275
Autor:
Krishna C. Mudumbi, Eric A. Burns, David J. Schodt, Zaritza O. Petrova, Anatoly Kiyatkin, Lucy W. Kim, Emma M. Mangiacapre, Irais Ortiz-Caraveo, Hector Rivera Ortiz, Chun Hu, Kumar D. Ashtekar, Keith A. Lidke, Diane S. Lidke, Mark A. Lemmon
Publikováno v:
Cell Reports, Vol 43, Iss 1, Pp 113603- (2024)
Summary: The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase with important roles in many cellular processes as well as in cancer and other diseases. EGF binding promotes EGFR dimerization and autophosphorylation through interac
Externí odkaz:
https://doaj.org/article/3090522f0d974b3a9a1c31bec81b0de1
Autor:
Iris K. van Alderwerelt van Rosenburgh, David M. Lu, Michael J. Grant, Steven E. Stayrook, Manali Phadke, Zenta Walther, Sarah B. Goldberg, Katerina Politi, Mark A. Lemmon, Kumar D. Ashtekar, Yuko Tsutsui
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Although small molecule tyrosine kinase inhibitors are effective in lung cancer driven by mutated EGFR, some receptor variants fail to respond. Here, the authors identify structural features of an important set of EGFR variants with reduced inhibitor
Externí odkaz:
https://doaj.org/article/b04886b84f654ae4b677dfc2b5e44cc2
Autor:
Fumin Shi, Jeannine M. Mendrola, Joshua B. Sheetz, Neo Wu, Anselm Sommer, Kelsey F. Speer, Jasprina N. Noordermeer, Zhong-Yuan Kan, Kay Perry, S. Walter Englander, Steven E. Stayrook, Lee G. Fradkin, Mark A. Lemmon
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109834- (2021)
Summary: WNTs play key roles in development and disease, signaling through Frizzled (FZD) seven-pass transmembrane receptors and numerous co-receptors including ROR and RYK family receptor tyrosine kinases (RTKs). We describe crystal structures and W
Externí odkaz:
https://doaj.org/article/0a50f419840142aeb7b781200e52336f
Complex Relationship between Ligand Binding and Dimerization in the Epidermal Growth Factor Receptor
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1306-1317 (2014)
The epidermal growth factor receptor (EGFR) plays pivotal roles in development and is mutated or overexpressed in several cancers. Despite recent advances, the complex allosteric regulation of EGFR remains incompletely understood. Through efforts to
Externí odkaz:
https://doaj.org/article/2a10d9751d404d5581278cd2a95c28ed
Autor:
Michael J. Grant, Jacqueline V. Aredo, Jacqueline H. Starrett, Paul Stockhammer, Iris K. van Alderwerelt van Rosenburgh, Anna Wurtz, Andrew J. Piper-Valillo, Zofia Piotrowska, Christina Falcon, Helena A. Yu, Charu Aggarwal, Dylan Scholes, Tejas Patil, Christina Nguyen, Manali Phadke, Fang-Yong Li, Joel Neal, Mark A. Lemmon, Zenta Walther, Katerina Politi, Sarah B. Goldberg
Publikováno v:
Clinical Cancer Research. 29:2123-2130
Purpose: The uncommon EGFR exon 19 deletion (ex19del), L747_A750>P, demonstrates reduced sensitivity to osimertinib compared with the common ex19del, E746_A750del in preclinical models. The clinical efficacy of osimertinib in patients with non–smal
Autor:
Ari-Matti Harri, Mark Paton, Maria Hieta, Jouni Polkko, Claire Newman, Jorge Pla-García, Joonas Leino, Terhi Mäkinen, Janne Kauhanen, Iina Jaakonaho, Agustín Sánchez-Lavega, Ricardo Hueso, Maria Genzer, Ralph D. Lorenz, Mark T Lemmon, Alvaro Vicente-Retortillo, Leslie Tamppari, Daniel Viúdez-Moreiras, Manuel de la Torre Juárez, Hannu Savijärvi, Jose Antonio Rodríguez-Manfredi, German Martinez
The Mars2020 Perseverance Rover landed successfully on the Martian surface on the Jezero Crater floor (18.44°N, 77.45°E) at Martian solar longitude, $L_s$, $\sim$5 in February 2021. Since then it has produced highly valuable environmental measureme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::160b3d083665d62370a09d0cdb87ba5a
https://doi.org/10.22541/essoar.168500355.59581586/v1
https://doi.org/10.22541/essoar.168500355.59581586/v1
Autor:
Teresa del Río Gaztelurrutia, Agustin Sanchez-Lavega, Ricardo Hueso, Asier Munguira, Mark T. Lemmon, Michael D. Smith, German Martinez, Jorge Pla-Garcia, Claire Newman, Daniel Viudez, Manuel de la Torre-Juarez, Jose Antonio Rodriguez-Manfredi
Pressure measurements by the MEDA sensor on board Perseverance Rover show oscillations in a wide range of temporal scales, from the seasonal evolution of average pressure to rapid fluctuations on the scale of a few seconds. In this work, we profit fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4af4b22bd448b48c0a25b7c9414ff07
https://doi.org/10.5194/egusphere-egu23-7173
https://doi.org/10.5194/egusphere-egu23-7173
Publikováno v:
Geophysical Research Letters. 50