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pro vyhledávání: '"Mark A. Lefers"'
Publikováno v:
Developmental Biology. 236:411-420
Much of our understanding of the Hedgehog (Hh) signaling pathway comes from Drosophila, where a gradient of Hh signaling regulates the function of the transcription factor Cubitus interruptus (Ci) at three levels: protein stabilization, nuclear impor
Autor:
Robert A. Holmgren, Mark A. Lefers
Publikováno v:
Current biology : CB. 12(12)
Proteolytic processing of Ci requires phosphorylation by the kinases Sgg/GSK3 and CK1. The newly identified phosphorylation sites form clusters with previously described PKA sites in which phosphorylation by PKA acts to prime subsequent phosphorylati