Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Mark A. Lauer"'
Publikováno v:
Journal of Inflammation, Vol 14, Iss 1, Pp 1-9 (2017)
Abstract Background Previous studies have demonstrated that ovalbumin sensitization promotes chronic asthma phenotype in murine asthma model. Human mesenchymal stem cells (hMSCs) are multipotent cells in vitro that have been shown to decrease inflamm
Externí odkaz:
https://doaj.org/article/4c09bd52230844b788ba3ebebffa288e
Autor:
Weiling Xu, Allison J. Janocha, Rachel A. Leahy, Ryan Klatte, Dave Dudzinski, Lori A. Mavrakis, Suzy A.A. Comhair, Mark E. Lauer, Calvin U. Cotton, Serpil C. Erzurum
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 513-519 (2014)
Air–liquid interface cell culture is an organotypic model for study of differentiated functional airway epithelium in vitro. Dysregulation of cellular energy metabolism and mitochondrial function have been suggested to contribute to airway diseases
Externí odkaz:
https://doaj.org/article/8345b9e109ab41ce92c9982bea3125a6
Publikováno v:
International Journal of Cell Biology, Vol 2015 (2015)
In normal airways, hyaluronan (HA) matrices are primarily located within the airway submucosa, pulmonary vasculature walls, and, to a lesser extent, the alveoli. Following pulmonary injury, elevated levels of HA matrices accumulate in these regions,
Externí odkaz:
https://doaj.org/article/6c3e55504c5d48e386ddbb597ff5d6a8
Autor:
Valbona Cali, Collin G. Johnson, X. Stavros Garantziotis, Hans Georg Wisniewski, Ronald J. Midura, Vandy P. Stober, Mark E. Lauer, Mark A. Aronica, Alana K. Majors
Publikováno v:
Journal of Biological Chemistry. 292:20845-20858
Exposure to pollutants, such as ozone, exacerbates airway inflammation and hyperresponsiveness (AHR). TNF-stimulated gene 6 (TSG-6) is required to transfer inter-α-inhibitor heavy chains (HC) to hyaluronan (HA), facilitating HA receptor binding. TSG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767cf41d38c29a0a75417123378640af
https://doi.org/10.1074/jbc.m116.756627
https://doi.org/10.1074/jbc.m116.756627
Autor:
K. Jane Grande-Allen, Andrew J. Stout, Brittany Matuska, Varun K. Krishnamurthy, Matthew C. Sapp, Mark E. Lauer
Publikováno v:
Matrix Biology. 62:40-57
Aortic valve disease (AVD) is one of the leading causes of cardiovascular mortality. Abnormal expression of hyaluronan (HA) and its synthesizing/degrading enzymes have been observed during latent AVD however, the mechanism of impaired HA homeostasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653c2789aaa611416f5bb71b0ade742b
https://doi.org/10.1016/j.matbio.2016.11.003
https://doi.org/10.1016/j.matbio.2016.11.003
Autor:
Brittany Matuska, Ronald J. Midura, James F. Chmiel, Suzy A.A. Comhair, Mark E. Lauer, Carol Farver, Tracey L. Bonfield
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 55:576-585
Hyaluronan (HA) has been used in treatment of cystic fibrosis (CF) via a nebulizer and has demonstrated success in clinical outcomes. HA is an important glycosaminoglycan that is cross-linked by heavy chains (HCs) from inter–α-inhibitor during inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d27237953cffbf2a6a723bb28b98825
https://doi.org/10.1165/rcmb.2015-0358oc
https://doi.org/10.1165/rcmb.2015-0358oc
Autor:
Liping Tian, Suzy A. A. Comhair, James Hiznay, Jarrod W. Barnes, Jacqueline Loftis, Raed A. Dweik, Mark E. Lauer
Publikováno v:
MethodsX
Graphical abstract
The building blocks of simple and complex oligosaccharides, termed sugar nucleotides, are often overlooked for their role in metabolic diseases and may hold the key to the underlying disease pathogenesis. Multiple reasons may
The building blocks of simple and complex oligosaccharides, termed sugar nucleotides, are often overlooked for their role in metabolic diseases and may hold the key to the underlying disease pathogenesis. Multiple reasons may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::879ff078430224727d3ba8f2b4858b03
Publikováno v:
Journal of Biological Chemistry. 291:1448-1455
Many cells, including murine airway epithelial cells, respond to a variety of inflammatory stimuli by synthesizing leukocyte-adhesive hyaluronan (HA) cables that remain attached to their cell surfaces. This study shows that air-liquid interface cultu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61e4a52949599690ef9e6a8d95c0109
https://doi.org/10.1074/jbc.m115.704288
https://doi.org/10.1074/jbc.m115.704288
Hyaluronan (HA) exhibits numerous important roles in physiology and pathologies, and these facts necessitate an ability to accurately and reproducibly measure its quantities in tissues and cell cultures. Our group previously reported a rigorous and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0355c33e4d4e4d1e7e9ec0e668fcaec
https://doi.org/10.1016/bs.mcb.2017.08.017
https://doi.org/10.1016/bs.mcb.2017.08.017
Autor:
Robert J. Linhardt, Anthony Calabro, Lingyun Li, Vincent C. Hascall, Georgiana Cheng, Elliott Lamkin, Eun Ji Joo, Mark E. Lauer
Publikováno v:
Journal of Biological Chemistry. 290:5156-5166
We present data that hyaluronan (HA) polysaccharides, about 14-86 monosaccharides in length, are capable of accepting only a single heavy chain (HC) from inter-α-inhibitor via transfer by tumor necrosis factor-stimulated gene 6 (TSG-6) and that this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74673ad20988522ef44f0d2d74d6ea7e
https://doi.org/10.1074/jbc.m114.636258
https://doi.org/10.1074/jbc.m114.636258