Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mark A. Lapack"'
Autor:
Arani Chanda, Shailendra Bordawekar, Samrat Mukherjee, John P. Higgins, Howard W. Ward, Mark A. LaPack, Adrian M. Daly, Bing-Shiou Yang, John D. Orr, James E. Morgado, Todd D. Maloney, George L. Reid, Aaron W. Garrett
Publikováno v:
Organic Process Research & Development. 19:1174-1185
The IQ Consortium reports on the current state of process analytical technology (PAT) for active pharmaceutical ingredient (API) manufacturing in branded pharmaceutical companies. The article describes the application of PAT in manufacturing and prov
Autor:
Duncan R. Thompson, Howard W. Ward, George L. Reid, Adrian M. Daly, Samrat Mukherjee, Mark A. LaPack, Arani Chanda, David A. Foley, John D. Orr
Publikováno v:
Organic Process Research & Development. 19:63-83
The IQ Consortium reports on the current state of process analytical technology (PAT) for active pharmaceutical ingredient (API) development in branded pharmaceutical companies. The article uses an API process workflow (process steps from raw materia
Autor:
Sze Wing Wong, Steven J. Doherty, Mark A. LaPack, Norma Scully, Zhenqi Shi, Gordon R. Lambertus, Robert A. Forbes, James Hermiller, Timothy T. Kramer
Publikováno v:
Applied Spectroscopy. 68:445-457
An on-line analytical method based on transmission near-infrared spectroscopy (NIRS) for the quantitative determination of water concentrations (in parts per million) was developed and applied to the manufacture of a pharmaceutical intermediate. Cali
Autor:
Ajit S. Shah, Thomas Rogers, James Murphy, Bruce E. Wise, D. Keith Anderson, Harish K. Santhanam, Mark A. Pietz, H. Peter Kleine, Derek B. Brown, V. H. Iskos, Jerry D. Clark, Melissa K. Lantz, Christine M. V. Moore, David V. Banaszak, Peter G. Ruminski, Czyzewski Ann M, Carlos A. Orihuela, Puneh S. Forouzi, Carl M. Knable, Gerald A. Weisenburger, Frank W. Muellner, Mark A. Lapack, Schilke Tobin C, Donald J. Gallagher, Albert D. Edeny, Ahmad Y. Sheikh
Publikováno v:
Organic Process Research & Development. 13:1088-1093
Studies directed toward the process research, development, and scale-up preparation of the potential αvβ3 integrin antagonist 1 are described. A convergent approach is detailed wherein tetrahydropyrimidine hydroxybenzoic acid 2 is linked to the β-
Autor:
Edward W. Conder, Roger Ryan Rothhaar, Mark A. LaPack, Jared W. Fennell, Timothy M. Braden, R. Brian Scherer, Jeffrey Czarnik, Jeffrey Thomas Vicenzi, Mark D. Argentine, Jeffrey G. Wei, John Arnold Werner, Robert T. Roginski, Schmid Christopher Randall, Steven E. Dunlap
Publikováno v:
Organic Process Research & Development. 13:131-143
The impact of several new technologies on the development of a manufacturing process for LY518674 is described. Extensive use of process analytical technology (PAT) throughout development, both at laboratory and pilot-plant scale, enabled data-rich e
Autor:
Michael A. Carr, Richard D. Miller, Joel P. Ott, Vien V. Khau, Rachel N. Richey, James R. Stout, Scott Alan Frank, Mark A. LaPack, Ruilin Gu, Hannah Yu, Tony Y. Zhang
Publikováno v:
Organic Process Research & Development. 12:218-225
A new synthetic route to LY2497282 (1), a potent and selective DPP IV inhibitor for the potential treatment of diabetes, suitable for the preparation of multikilogram quantities is described. The key step involved a stereoselective addition of the di
Publikováno v:
Organic Process Research & Development. 6:700-705
The combination of multidimensional analytical technology to form a single nth-order analyzer can produce reaction process data more efficiently and may provide data that are inaccessible using conventional techniques. A 3rd-order analyzer was assemb
Autor:
Wayne W. Blaser, Robert A. Bredeweg, Richard S. Harner, Mark A. LaPack, Anne. Leugers, Daniel P. Martin, Randy J. Pell, Jerome. Workman, Larry G. Wright
Publikováno v:
Analytical Chemistry. 67:47-70
Publikováno v:
Analytical chemistry. 68(17)
Membrane extractors comprising a membrane house inside of a valve have been developed to separate compounds of interest from a sample matrix and introduce these compounds into a mass spectrometer. Experimental control over parameters that affect perm
Publikováno v:
Analytical Chemistry. 63:1631-1637
A membrane extraction maw spectrometry (MEMS) tech& que was developed for the on-line analyrk of organlc components of multiple liquid and gas dreams. Sllkone hollowfiber “branos allow for the extrcrctkn of orgalc chedcdr from compkx ad dMy matrice