Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Mark A. Jarosinski"'
Autor:
Balamurugan Dhayalan, Michael D. Glidden, Alexander N. Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B. Phillips, Faramarz Ismail-Beigi, Mark A. Jarosinski, Richard D. DiMarchi, Michael A. Weiss
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
The mutant proinsulin syndrome is a monogenic cause of diabetes mellitus due to toxic misfolding of insulin’s biosynthetic precursor. Also designated mutant INS-gene induced diabetes of the young (MIDY), this syndrome defines molecular determinants
Externí odkaz:
https://doaj.org/article/ac8abdb348a7445ab68c20aba3dbef24
Autor:
Mark A. Jarosinski, Balamurugan Dhayalan, Yen-Shan Chen, Deepak Chatterjee, Nicolás Varas, Michael A. Weiss
Publikováno v:
Molecular Metabolism, Vol 52, Iss , Pp 101325- (2021)
Background: The discovery of insulin in 1921 and its near-immediate clinical use initiated a century of innovation. Advances extended across a broad front, from the stabilization of animal insulin formulations to the frontiers of synthetic peptide ch
Externí odkaz:
https://doaj.org/article/934701eebaff4526bc2d5c33215bdbfa
Autor:
Deepak Chatterjee, Mark A. Jarosinski, Balamurugan Dhayalan, Michael A. Weiss, Nischay K. Rege
Publikováno v:
Diabetologia
Insulin replacement therapy for diabetes mellitus seeks to minimise excursions in blood glucose concentration above or below the therapeutic range (hyper- or hypoglycaemia). To mitigate acute and chronic risks of such excursions, glucose-responsive i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2225e21e72676d79f8bb4bfabbac9bb
https://doi.org/10.1007/s00125-021-05422-6
https://doi.org/10.1007/s00125-021-05422-6
Autor:
Balamurugan Dhayalan, Michael D. Glidden, Alexander N. Zaykov, Yen-Shan Chen, Yanwu Yang, Nelson B. Phillips, Faramarz Ismail-Beigi, Mark A. Jarosinski, Richard D. DiMarchi, Michael A. Weiss
Publikováno v:
Frontiers in endocrinology. 13
The mutant proinsulin syndrome is a monogenic cause of diabetes mellitus due to toxic misfolding of insulin’s biosynthetic precursor. Also designatedmutant INS-gene induced diabetes of the young(MIDY), this syndrome defines molecular determinants o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76981e7bf5dc8d1ca68ff3e3d55e6c55
https://pubmed.ncbi.nlm.nih.gov/35299972
https://pubmed.ncbi.nlm.nih.gov/35299972
Autor:
Peter Arvan, Faramarz Ismail-Beigi, Yanwu Yang, Mark A. Jarosinski, Balamurugan Dhayalan, Nelson B. Phillips, Rachel Grabowski, Shayan Poordian, Michael A. Weiss, Deepak Chatterjee, Yen-Shan Chen
Diverse heterozygous mutations in the human insulin gene cause a monogenic diabetes mellitus (DM) syndrome due to toxic misfolding of the variant proinsulin. Whereas mutations that add or remove cysteines (thereby leading to an odd number of thiol gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a197901d7b98e37cca9a1f2401bf8f3
https://doi.org/10.1101/2021.09.24.461687
https://doi.org/10.1101/2021.09.24.461687
Autor:
Nicolás Varas, Deepak Chatterjee, Yen-Shan Chen, Mark A. Jarosinski, Michael A. Weiss, Balamurugan Dhayalan
Publikováno v:
Molecular Metabolism
Molecular Metabolism, Vol 52, Iss, Pp 101325-(2021)
Molecular Metabolism, Vol 52, Iss, Pp 101325-(2021)
Background The discovery of insulin in 1921 and its near-immediate clinical use initiated a century of innovation. Advances extended across a broad front, from the stabilization of animal insulin formulations to the frontiers of synthetic peptide che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0709598066ae9bc3f7328c43341d4683
http://europepmc.org/articles/PMC8513154
http://europepmc.org/articles/PMC8513154
Autor:
Balamurugan Dhayalan, Mamuni Swain, Norman Metanis, Michael A. Weiss, Faramarz Ismail-Beigi, Mark A. Jarosinski, Ali Mirsalehi, Nischay K. Rege, Yen-Shan Chen, Nelson B. Phillips
Publikováno v:
Chemistry
Long-acting insulin analogues represent the most prescribed class of therapeutic proteins. An innovative design strategy was recently proposed: diselenide substitution of an external disulfide bridge. This approach exploited the distinctive physicoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc45731b4026ab050095f7a3e85c91d7
https://pubmed.ncbi.nlm.nih.gov/31958351
https://pubmed.ncbi.nlm.nih.gov/31958351
Autor:
Balamurugan Dhayalan, Laurie Broadwater, Yanwu Yang, Thomas Hattier, Jeremy Gleaton, Nelson B. Phillips, Deepak Chatterjee, Yen-Shan Chen, Michael C. Lawrence, Michael A. Weiss, M. Dodson Michael, Mark A. Jarosinski, Yule Liu
Publikováno v:
Journal of the Endocrine Society
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Insulin signaling requires conformational change: whereas the free hormone and its receptor each adopt autoinhibited conformations, their binding leads to large-scale structural reorganization. To test the coupling between insulin’s “opening” a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28213b7d202309d177cc495f6bc734a
http://europepmc.org/articles/PMC8090162
http://europepmc.org/articles/PMC8090162
Autor:
Jean-Claude Louis, Francis Hall Martin, Gay-May Wu, Stephen J. Wood, Shirley Steavenson, Linda O. Narhi, Frederick W. Jacobsen, Martin Citron, Jette Wypych, Anja Leona Biere, Yijia Jiang, Dan Anafi, Mark A. Jarosinski
Publikováno v:
Journal of Biological Chemistry. 275:34574-34579
Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies. Recently, two point mutations in alpha-synuclein were found to be associated with familial PD, but as of ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6c508bf5f278d597e854d07b2be6b4
https://doi.org/10.1074/jbc.m005514200
https://doi.org/10.1074/jbc.m005514200
Autor:
Jones T, Brian D. Bennett, Yunjen Young, Jingwen Zhang, Mitsuru Haniu, Thomas J. Zamborelli, Mark A. Jarosinski, Dodson Ws, Douglas M. Lenz, Bennet J. Harding, Chuan-Fa Liu
Publikováno v:
The Journal of Peptide Research. 55:359-371
The 52-residue alpha/beta chimera of the epidermal growth factor-like domain in neu differentiation factor (NDFealpha/beta) has been synthesized and folded to form a three disulfide bridge (Cys182-Cys196, Cys190-Cys210, Cys212-Cys221) containing pept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28ed17cf8a4005a9b68ffd21a6b1e1a6
https://doi.org/10.1034/j.1399-3011.2000.00672.x
https://doi.org/10.1034/j.1399-3011.2000.00672.x