Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mark A. Hopkin"'
Publikováno v:
Org. Biomol. Chem.. 11:1822-1839
A flow-based route to imatinib, the API of Gleevec, was developed and the general procedure then used to generate a number of analogues which were screened for biological activity against Abl1. The flow synthesis required minimal manual intervention
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f151e57baa3bbeb1105b0db12b3c7b
https://doi.org/10.1039/c2ob27002a
https://doi.org/10.1039/c2ob27002a
Publikováno v:
Synthesis. 2008:1688-1702
A multi-component reaction has been developed allowing direct access to pyrroloisoquinolines and pyrroloquinolines with new, electron-rich substitution patterns. The synthesised amino-substituted heterocyclic compounds and intermediates involved in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaabf55e30b6b018a8858f4e17edd572
https://doi.org/10.1055/s-2008-1067048
https://doi.org/10.1055/s-2008-1067048
Publikováno v:
Vascular Surgery. 31:441-449
Hypothermia has been shown to have pathophysiological consequences on endothelial and smooth muscle cell functions. The impact of rewarming on vessels is unknown. This study examines the contractile functions of two sets of rabbit external jugular ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ca985f386dfa49bbc7d815f92d31a2f
https://doi.org/10.1177/153857449703100406
https://doi.org/10.1177/153857449703100406
Publikováno v:
ChemInform. 44
Imatinib (1), nilotinib (2) and dasatinib (3) are Bcr-Abl tyrosine kinase inhibitors approved for the treatment of chronic myelogenous leukemia (CML). This review collates information from the journal and patent literature to provide a comprehensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::599f00fb98908fe8cf854c8923b356d5
https://doi.org/10.1002/chin.201328212
https://doi.org/10.1002/chin.201328212
Publikováno v:
Vascular Medicine. 1:103-107
Hypothermia has pathophysiological consequences on endothelial and smooth muscle cell function. This study investigates the impact on venous relaxation of hypothermia and rewarming following hypothermic exposure. In vitro isometric relaxation respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a9351623456b4d2906a13cf8c4d2e7
https://doi.org/10.1177/1358863x9600100203
https://doi.org/10.1177/1358863x9600100203
Publikováno v:
Organicbiomolecular chemistry. 11(11)
Imatinib (1), nilotinib (2) and dasatinib (3) are Bcr-Abl tyrosine kinase inhibitors approved for the treatment of chronic myelogenous leukemia (CML). This review collates information from the journal and patent literature to provide a comprehensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fa2497edb90523cab5ba16acfa9952
https://pubmed.ncbi.nlm.nih.gov/23247657
https://pubmed.ncbi.nlm.nih.gov/23247657
Autor:
Catherine F. Carter, Jon G. Goode, Heiko Lange, Mark D. Hopkin, Steven V. Ley, Ian R. Baxendale, Adrian Burke
In order to use segmented chemical flow processing in more complex reaction sequences, a method has been developed to precisely control the addition of reagent streams during multi-step operations. Using in-line infra-red monitoring with a new LabVIE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9780b03237ac09b457b3558fff22d758
http://hdl.handle.net/11588/761069
http://hdl.handle.net/11588/761069
Publikováno v:
ChemInform. 39
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e955aa749aa8cca2d135a89bf25fc7d
https://doi.org/10.1002/chin.200841157
https://doi.org/10.1002/chin.200841157
Autor:
Mark Ladlow, C. M. Griffiths-Jones, David Joszef Tapolczay, Mark D. Hopkin, and Emma Vickerstaffe, Daniel Jönsson, Steven V. Ley
Publikováno v:
Journal of combinatorial chemistry. 9(3)
A fully automated flow-through process for the production of secondary sulfonamides is presented. Primary sulfonamides were monoalkylated using a two-step “catch and release” protocol to generate library products of high purity. The automated flo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb34561b03c0ddd6ab539d726ab66b5
https://pubmed.ncbi.nlm.nih.gov/17348713
https://pubmed.ncbi.nlm.nih.gov/17348713
Publikováno v:
Chemical Communications. 46:2450
A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7be5e248dddc7f0ef979ef1b1a3282b
https://doi.org/10.1039/c001550d
https://doi.org/10.1039/c001550d