Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mark A. Helle"'
Publikováno v:
ACS Agricultural Science & Technology. 1:499-506
Publikováno v:
Industrial Crops and Products. 178:114563
Autor:
Mark A Helle, Mark A. Wolf, Brian P. Haney, Qiang Yang, Cheng Guo, Bernhard J. Paul, Lingling Wang, Daniel K. Keefe, Paul R. Bruzinski, Nathan T. Reynolds, Mark A. Mortensen, Nicole L. Malinowski
Publikováno v:
Organic Process Research & Development. 16:1811-1817
Process development and production of a novel tubulin inhibitor are described. The desired API was obtained through selective iodination of the 12′ position of vinblastine and subsequent thiomethylation. Most of the impurities were identified, and
Autor:
Brian T. Gregg, Zinovy Itov, Mark A Helle, Harold Meckler, Joyce C. Knutson, Mary E. Mateo, William B. Geiss, Lisa D. Coutts, Mark W. Zettler, Chi-Hsin R. King
Publikováno v:
Organic Process Research & Development. 6:246-255
This contribution describes the first stereospecific synthesis of 24(S)-hydroxyvitamin D2 (1), a metabolite of vitamin D2. This metabolite acts as a prodrug for 1α,24(S)-dihydroxyvitamin D2 (2), wh...
Autor:
Alicia J Habershaw, Bernard Paul, Mark A Helle, David C Burdick, Peter R. Guzzo, Russell J. DeOrazio, Mark A. Wolf
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1424-1426
A novel series of Delta9-tetrahydrocannabinol (Delta9-THC) analogues were synthesized to determine their potential as cannabinoid receptor modulators. Chemistry focused on conversion of the phenol of Delta9-THC to other functionality through palladiu
Publikováno v:
ChemInform. 23
A surprisingly large stereodirecting effect for the allylic alkoxy-substituent (> 4 kcal/mol) is revealed in the amidomercuration cyclization of an unsaturated amidal in which the stereodirecting effect of the allylic alkoxy-substituent competes agai
Publikováno v:
Tetrahedron Letters. 31:6765-6768
A surprisingly large stereodirecting effect for the allylic alkoxy-substituent (> 4 kcal/mol) is revealed in the amidomercuration cyclization of an unsaturated amidal in which the stereodirecting effect of the allylic alkoxy-substituent competes agai
Publikováno v:
ChemInform. 21
Salicylamide condenses with γ,δ- or δ,e-unsaturated aldehydes to give cyclic amidals which readily undergo diastereoselective mercury(II)-mediated amidocyclization. The resulting products serve as versatile intermediates for further elaboration as
Publikováno v:
Tetrahedron Letters. 27:1257-1260
Treatment of esters with diisobutylaluminum hydride (DIBAL) in the presence of lithio-trialkylphosphonoacetate results in improved yields of the homologated α, β-unsaturated esters. The problematic overreduction, which has previously observed in th
Publikováno v:
Tetrahedron Letters. 30:7321-7324
Salicylamide condenses with γ,δ- or δ,e-unsaturated aldehydes to give cyclic amidals which readily undergo diastereoselective mercury(II)-mediated amidocyclization. The resulting products serve as versatile intermediates for further elaboration as