Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Mark A. Hartsky"'
Publikováno v:
Experimental Lung Research. 28:641-670
Apoptosis, or programmed cell death, has been reported to play an important role in the resolution of pulmonary inflammation. This study was undertaken to investigate the role of apoptosis in resolving particle-induced lung inflammatory responses in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c79be276749d956e2adb1180400b3b
https://doi.org/10.1080/01902140260426742
https://doi.org/10.1080/01902140260426742
Publikováno v:
Environmental Health Perspectives
This study compared pulmonary effects of para-aramid respirable-sized, fiber-shaped particles (RFP) (p-aramid fibrils) and chrysotile asbestos fiber exposures in rats. Additional p-aramid inhalation studies were conducted in hamsters to compare speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad1b4f85a4896aa408229e6212ebd0f
https://doi.org/10.1289/ehp.97105s51219
https://doi.org/10.1289/ehp.97105s51219
Publikováno v:
Toxicology Letters. 88:287-292
This study was designed to compare the pulmonary cellular proliferative effects of inhaled, size-separated preparations of chrysotile asbestos fibres with similar aerosol fibre concentrations of para-aramid fibrils. Following fibre preparation, rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27f1419ae155e91f2e9f7cfb5cca91e
https://doi.org/10.1016/0378-4274(96)03751-4
https://doi.org/10.1016/0378-4274(96)03751-4
Publikováno v:
Toxicology Letters. 88:249-253
Long-term inhalation exposures to high dust burdens can produce tumors or proliferative keratin cysts in the lungs of exposed rats. We hypothesized that dust burdens which overwhelm lung clearance mechanisms are associated with sustained cellular pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38eae7f50c79b0a5f778685819ce73c3
https://doi.org/10.1016/0378-4274(96)82678-6
https://doi.org/10.1016/0378-4274(96)82678-6
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 15:268-274
The time course of neutrophil recruitment into the lung, neutrophilic chemotactic activity, and the gene expression of neutrophilic chemokines by lavaged cells was determined after intratracheal instillation of various particles. Low-toxicity, low-so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84abc5f9d915734e2fecc5b04119dfb5
https://doi.org/10.1165/ajrcmb.15.2.8703484
https://doi.org/10.1165/ajrcmb.15.2.8703484
Publikováno v:
Environmental Health Perspectives
Fiber dimension and durability are recognized as important features in influencing the development of pulmonary carcinogenic and fibrogenic effects. Using a short-term inhalation bioassay, we have studied pulmonary deposition and clearance patterns a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a45303576a54603e03ad92447d796a8
https://doi.org/10.1289/ehp.94102s5151
https://doi.org/10.1289/ehp.94102s5151
Autor:
Mark A. Hartsky, David B. Warheit
Publikováno v:
Microscopy Research and Technique. 26:412-422
Alveolar macrophages (AM) play an important role in clearing inhaled particles from the lung. The mechanisms through which macrophages identify particles that have been deposited in the alveolar regions is not well understood, although macrophage mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb19db9ba7487a42ba5fa4a31379ca6
https://doi.org/10.1002/jemt.1070260509
https://doi.org/10.1002/jemt.1070260509
Publikováno v:
Environmental Research. 56:186-203
Complement-mediated mechanisms are known to play a role in pulmonary inflammation and clearance responses to some types of inhaled particles. The present studies were undertaken to investigate the role of complement in mediating pulmonary inflammatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe31ae187baeb566718c116aa62da0e5
https://doi.org/10.1016/s0013-9351(05)80008-8
https://doi.org/10.1016/s0013-9351(05)80008-8
Publikováno v:
Fundamental and Applied Toxicology. 16:590-601
This study was designed to complement a traditional subchronic inhalation toxicity study with Ludox colloidal silica. CD rats were exposed nose-only for 2 or 4 weeks at concentrations of 0, 10, 50, and 150 mg/m3 Ludox (dried SiO2). Additional groups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb18157a864faf843d97b72785833ba
https://doi.org/10.1016/0272-0590(91)90098-o
https://doi.org/10.1016/0272-0590(91)90098-o
Publikováno v:
Toxicology and Applied Pharmacology. 107:350-368
This paper describes a short-term inhalation bioassay for evaluating the lung toxicity of inhaled particulate materials. To validate the method, rats were exposed for 6 hr or 3 days to various concentrations of either aerosolized alpha-quartz silica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732735bb2805c437f29e8925785722ef
https://doi.org/10.1016/0041-008x(91)90215-z
https://doi.org/10.1016/0041-008x(91)90215-z