Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mark A. Elban"'
Autor:
Young Do Kwon, Judith M LaLonde, Yongping Yang, Mark A Elban, Akihiro Sugawara, Joel R Courter, David M Jones, Amos B Smith, Asim K Debnath, Peter D Kwong
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85940 (2014)
Efforts to develop therapeutic agents that inhibit HIV-1 entry have led to the identification of several small molecule leads. One of the most promising is the NBD series, which binds within a conserved gp120 cavity and possesses para-halogen substit
Externí odkaz:
https://doaj.org/article/e73d4da82ce24696811bc79c63f7a780
Publikováno v:
Journal of Natural Products. 75:577-585
Structure-activity studies were employed to investigate the stabilization of DNA-topoisomerases I and II covalent binary complexes by topopyrone analogues. The synthesis of five new topopyrone derivatives and study of their ability to stabilize DNA-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419d912cedd34e81e7249d4312e74be2
https://doi.org/10.1021/np200777z
https://doi.org/10.1021/np200777z
Autor:
Joseph Sodroski, Amos B. Smith, Akihiro Sugawara, Takahiro Soeta, Joel R. Courter, Amy M. Princiotto, Mark A. Elban, Judith M. LaLonde, Ernesto Freire, Navid Madani, Young Do Kwon, Peter D. Kwong, Arne Schön
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:91-101
The low-molecular-weight compound JRC-II-191 inhibits infection of HIV-1 by blocking the binding of the HIV-1 envelope glycoprotein gp120 to the CD4 receptor and is therefore an important lead in the development of a potent viral entry inhibitor. Rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83460aeb3280e55a34a9f4027994ef0b
https://doi.org/10.1016/j.bmc.2010.11.049
https://doi.org/10.1016/j.bmc.2010.11.049
Autor:
Sidney M. Hecht, Mark A. Elban
Publikováno v:
The Journal of Organic Chemistry. 73:785-793
The topopyrones represent a new class of highly cytotoxic topoisomerase I poisons. Efficient total syntheses of all four naturally occurring members of this class have been accomplished. Key elements of the syntheses include Diels-Alder reactions emp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34a31263f3d6a72f33164fdc0a3075d
https://doi.org/10.1021/jo702487r
https://doi.org/10.1021/jo702487r
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:6119-6125
Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771bd21dea97d276ca0589205265a0f6
https://doi.org/10.1016/j.bmc.2007.06.035
https://doi.org/10.1016/j.bmc.2007.06.035
Autor:
Yongping Yang, Akihiro Sugawara, Young Do Kwon, Amos B. Smith, Judith M. LaLonde, Joel R. Courter, Mark A. Elban, Peter D. Kwong, Asim K. Debnath, David M. Jones
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 1, p e85940 (2014)
PLoS ONE, Vol 9, Iss 1, p e85940 (2014)
Efforts to develop therapeutic agents that inhibit HIV-1 entry have led to the identification of several small molecule leads. One of the most promising is the NBD series, which binds within a conserved gp120 cavity and possesses para-halogen substit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896ecf22b2fb2aa19a0f0264a97b3987
https://pubmed.ncbi.nlm.nih.gov/24489681
https://pubmed.ncbi.nlm.nih.gov/24489681
Publikováno v:
Journal of the American Chemical Society. 130(39)
The topopyrones are fungal natural products shown previously to act as poisons of human DNA topoisomerase I. Recent total syntheses of the four known naturally occurring members of this class of compounds have enabled more detailed biochemical charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93fb4fee8c8cbb1b5a91d652cf590f9
https://pubmed.ncbi.nlm.nih.gov/18774813
https://pubmed.ncbi.nlm.nih.gov/18774813
Autor:
Sidney M. Hecht, Mark A. Elban
Publikováno v:
ChemInform. 39
The topopyrones represent a new class of highly cytotoxic topoisomerase I poisons. Efficient total syntheses of all four naturally occurring members of this class have been accomplished. Key elements of the syntheses include Diels-Alder reactions emp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e5439e865bd0923fe9e1dbf4eed2477
https://doi.org/10.1002/chin.200822210
https://doi.org/10.1002/chin.200822210