Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Mark A. Dominick"'
Autor:
C. Robbie Waites, Jeffrey D. Moehlenkamp, Amy J. Reisinger, Lora L. Arnold, Sarah H. Tannehill-Gregg, Samuel M. Cohen, Beth E. Schilling, David A. Stock, Thomas P. Sanderson, Mark A. Dominick
Publikováno v:
Toxicologic Pathology. 37:293-305
In carcinogenicity studies with PPAR γ and α/γ agonists, urinary bladder tumors have been reported in Harlan Sprague-Dawley (HSD) and Charles River Sprague-Dawley (SD) but not Wistar (WI) rats, with urolithiasis purported to be the inciting event.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71826813dbfdeefa291c53c769ef4fe7
https://doi.org/10.1177/0192623309332990
https://doi.org/10.1177/0192623309332990
Publikováno v:
Toxicological Sciences. 100:248-258
The toxicity of muraglitazar, an oxybenzylglycine, nonthiazolidinedione peroxisome proliferator-activated receptor (PPAR) α/γ agonist, was evaluated in a comprehensive nonclinical toxicology program that included single-dose oral toxicity studies i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0e4e9f52419a16bda2728055295de26
https://doi.org/10.1093/toxsci/kfm193
https://doi.org/10.1093/toxsci/kfm193
Autor:
Samuel M. Cohen, James Mitroka, Martin Cano, Mark A. Dominick, M. Randy White, C. Robbie Waites, Lora L. Arnold, Terry Van Vleet, Thomas P. Sanderson, Beth E. Schilling
Publikováno v:
Toxicological Sciences. 96:58-71
Muraglitazar, a PPARa/g dual agonist, was dosed orally to rats once daily for 13 weeks to evaluate urinary and urothelial changes of potential relevance to urinary bladder tumorigenesis. Groups of 17 young or aged rats per sex were fed a normal or 1%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e537d87061d08b00aeab171e37a4f68
https://doi.org/10.1093/toxsci/kfl176
https://doi.org/10.1093/toxsci/kfl176
Autor:
Oliver P. Flint, Mark A. Dominick, James E. Proctor, Nuggehally R. Srinivas, Amy E. Weiss, Stephen K. Durham, Beth E. Schilling, Gene E. Schulze
Publikováno v:
International Journal of Toxicology. 18:285-296
One-month intranasal toxicity studies were conducted with BMS-181885 at doses of 1.5, 9, or 15 mg/animal/day in rats and 4, 24, or 40 mg/animal/day in monkeys. A 1-month intermittent intranasal toxicity study was also conducted in monkeys at doses of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec8ff6c7e153219cafdf4754efa80bc3
https://doi.org/10.1080/109158199225206
https://doi.org/10.1080/109158199225206
Publikováno v:
Journal of Cardiovascular Pharmacology. 2:268-282
Angiotensin-converting enzyme (ACE) inhibitors have proven to be effective therapeutic agents for treatment of hypertension and congestive heart failure (CHF). Because of the role the renin-angiotensin system (RAS) plays in maintaining renal homeosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70211c6c5f2881678ed087989c631264
https://doi.org/10.1097/00005344-199411000-00015
https://doi.org/10.1097/00005344-199411000-00015
Toxicologic Effects of a Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor in Cynomolgus Monkeys
Publikováno v:
Toxicologic Pathology. 22:510-518
PD 132301-2, an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, was administered orally to cynomolgus monkeys for 2 wk at doses of 25, 50, 100, and 200 mg/kg to assess potential subacute toxicity. Sporadic episodes of soft feces and diarrhea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1814250a998822afa8140fe7144623
https://doi.org/10.1177/019262339402200505
https://doi.org/10.1177/019262339402200505
Autor:
Daniel Potenta, Arthur Roth, Lewis B. Kinter, Carl L. Alden, Thomas Singer, Charles R. Mahrt, Joseph J. DeGeorge, Andrew R. Kraynak, John Evans, Bruce A. Trela, Richard Perry, Ronny Fransson-Steen, Jochen Woicke, Rabih Slim, Susan E. Turnquist, Matt Liu, David Brewster, Sandra De Jonghe, Karyn Colman, Douglas A. Keller, Vanessa Bosmans, Oliver C. Turner, Mark A. Dominick, Sivert Bjurström, M. Vijayaraj Reddy, James R. Hailey, Richard D. Storer, Frank D. Sistare, James R. Myer, Marjolein van Heerden, Keith A. Soper, Philip Sherratt, Daniel Morton, James H. Stoltz, Joel Christensen, Dirk Mariën, Jean-Guy Bienvenu
Publikováno v:
Toxicologic pathology. 39(4)
Data collected from 182 marketed and nonmarketed pharmaceuticals demonstrate that there is little value gained in conducting a rat two-year carcinogenicity study for compounds that lack: (1) histopathologic risk factors for rat neoplasia in chronic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e78b45bc8e9666442a4bfeec8f308d
https://pubmed.ncbi.nlm.nih.gov/21971937
https://pubmed.ncbi.nlm.nih.gov/21971937
Autor:
A. W. Gough, Walter F. Bobrowski, Thomas M.A. Bocan, E. J. Mcguire, J. F. Reindel, Mark A. Dominick
Publikováno v:
Fundamental and Applied Toxicology. 20:217-224
Subacute Toxicity of a Novel Inhibitor of Acyl-CoA:Cholesterol Acyltransferase in Beagle Dogs. Dominick, M. A., McGuire, E. J., Reindel, J. F., Bobrowski, W. F., Bocan, T. M. A., and Gough, A. W. (1993). Fundam. Appl. Toxicol. 20, 217-224. PD 132301-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8e3f5a25a2fa58f644da10b2148ef1
https://doi.org/10.1006/faat.1993.1029
https://doi.org/10.1006/faat.1993.1029
Publikováno v:
Toxicologic Pathology. 21:54-62
PD 132301-2, a novel inhibitor of acyl-CoA: cholesterol acyltransferase, is adrenotoxic to several laboratory animal species. Morphogenesis of a zona fasciculata-specific cytotoxicity was evaluated in male Hartley guinea pigs administered 100 mg/kg o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504c584c89cbc41e2389bf8beddc12b5
https://doi.org/10.1177/019262339302100107
https://doi.org/10.1177/019262339302100107