Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Mark A. Dennis"'
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the CD98 heavy chain (CD98hc or SLC3
Externí odkaz:
https://doaj.org/article/c0dcaba8ffc04890ade94c8b75b21509
Publikováno v:
Communications Physics, Vol 5, Iss 1, Pp 1-8 (2022)
Skyrmions and hopfions are topological elementary excitations originally discussed in particle physics and field theory, and are also created in optical fields. The authors show theoretically that the topology of light beams can be transformed into o
Externí odkaz:
https://doaj.org/article/8c31f0d10ecd4b0daaf6d3ebde9afb52
Autor:
Danica Sugic, Ramon Droop, Eileen Otte, Daniel Ehrmanntraut, Franco Nori, Janne Ruostekoski, Cornelia Denz, Mark R. Dennis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
One way to describe a particle is as a localised, 3-dimensional topological state, such as a skyrmion or hopfion. Here, the authors demonstrate and characterise particle-like skyrmionic hopfions in a free-space structured light beam.
Externí odkaz:
https://doaj.org/article/c7a2569c99bc4ce9806639665c797996
Autor:
Kylie S. Chew, Robert C. Wells, Arash Moshkforoush, Darren Chan, Kendra J. Lechtenberg, Hai L. Tran, Johann Chow, Do Jin Kim, Yaneth Robles-Colmenares, Devendra B. Srivastava, Raymond K. Tong, Mabel Tong, Kaitlin Xa, Alexander Yang, Yinhan Zhou, Padma Akkapeddi, Lakshman Annamalai, Kaja Bajc, Marie Blanchette, Gerald Maxwell Cherf, Timothy K. Earr, Audrey Gill, David Huynh, David Joy, Kristen N. Knight, Diana Lac, Amy Wing-Sze Leung, Katrina W. Lexa, Nicholas P. D. Liau, Isabel Becerra, Mario Malfavon, Joseph McInnes, Hoang N. Nguyen, Edwin I. Lozano, Michelle E. Pizzo, Elysia Roche, Patricia Sacayon, Meredith E. K. Calvert, Richard Daneman, Mark S. Dennis, Joseph Duque, Kapil Gadkar, Joseph W. Lewcock, Cathal S. Mahon, René Meisner, Hilda Solanoy, Robert G. Thorne, Ryan J. Watts, Y. Joy Yu Zuchero, Mihalis S. Kariolis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a16cb8fb950d46f9ab274a050ec42452
Autor:
Henry R. Maun, Rajesh Vij, Benjamin T. Walters, Ashley Morando, Janet K. Jackman, Ping Wu, Alberto Estevez, Xiaocheng Chen, Yvonne Franke, Michael T. Lipari, Mark S. Dennis, Daniel Kirchhofer, Claudio Ciferri, Kelly M. Loyet, Tangsheng Yi, Charles Eigenbrot, Robert A. Lazarus, James T. Koerber
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
β-tryptases are responsible for most of the proteolytic activity during mast cell activation. Here, the authors develop β-tryptase-inhibiting antibodies and provide structural and biochemical evidence that the bivalency of the antibodies is a prere
Externí odkaz:
https://doaj.org/article/731be2a1b0e94f0d9e6e6bb1c65b39da
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Propagation-invariant beams have been up to now only available in a few realizations or for specific applications. Here, the authors demonstrate two methods for generating propagation-invariant beams with fully customizable intensity profiles in a co
Externí odkaz:
https://doaj.org/article/4afc27e41cef4058890b6692670b3823
Publikováno v:
Communications Physics, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/03bab22fd2d34ce48b932d743ee09fa9
Autor:
Scarlett J Barker, Mai B Thayer, Chaeyoung Kim, David Tatarakis, Matthew Simon, Rebekah L Dial, Lizanne Nilewski, Robert C Wells, Yinhan Zhou, Megan Afetian, Alfred Chappell, Kylie S Chew, Johann Chow, Allisa Clemens, Claire B Discenza, Jason Dugas, Chrissa Dwyer, Timothy Earr, Connie Ha, David Huynh, Srini Jayaraman, Wanda Kwan, Cathal Mahon, Michelle Pizzo, Elysia Roche, Laura Sanders, Alexander Stergioulis, Raymond Tong, Hai Tran, Joy Zuchero, Anthony A Estrada, Kapil Gadkar, Christopher MM Koth, Pascal E Sanchez, Robert G Thorne, Ryan J Watts, Thomas Sandmann, Lesley Kane, Frank Rigo, Mark S Dennis, Joseph W Lewcock, Sarah L DeVos
Antisense oligonucleotides (ASO) are promising therapies for neurological disorders, though they are unable to cross the blood-brain barrier (BBB) and must be delivered directly to the central nervous system (CNS). Here, we use a human transferrin re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56046f97df89d6a2d15a721b2fca4f31
https://doi.org/10.1101/2023.04.25.538145
https://doi.org/10.1101/2023.04.25.538145
Autor:
Jagath R. Junutula, Paul Polakis, Richard H. Scheller, Mark S. Dennis, Deepak Sampath, Jo-Anne Hongo, Helga Raab, Katherine R. Kozak, Aimee Fourie-O'Donohue, Ron Firestein, Robert Piskol, Eric Cheng, Mary Ann T. Go, Kirsten A. Poon, Fiona Zhong, Rachana Ohri, Coenraad Kuijl, Dongwei Li, Melissa M. Schutten, Meredith Hazen, Yvonne Chen, Lisa M. Crocker, Sunil Bhakta
Figure S1. Validation of anti-GFRA1 antibodies (R&D systems and GNE-8H6) for the use of Immunohistochemistry (IHC) analysis; Figure S2. ELISA analyses to test binding specificity of anti-GFRA1 antibodies to GFRA1 (A) and GFRA2 (B) extra cellular doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100a6557ca8c0f2a229a1ced8e41d71e
https://doi.org/10.1158/1535-7163.22505118
https://doi.org/10.1158/1535-7163.22505118
Autor:
C. Andrew Boswell, Teemu T. Junttila, Saileta Prabhu, Mark S. Dennis, Sean B. Joseph, Kedan Lin, Klara Totpal, Robyn Clark, Maria Hristopoulos, Jason Ho, Dionysos Slaga, Jeffrey Eastham-Anderson, Ji Li, Amy A. Lo, Nene Takahashi, Danielle Mandikian
Anti-HER2/CD3, a T-cell–dependent bispecific antibody (TDB) construct, induces T-cell–mediated cell death in cancer cells expressing HER2 by cross-linking tumor HER2 with CD3 on cytotoxic T cells, thereby creating a functional cytolytic synapse.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60ecae480ffb1c898949cde0e394c25
https://doi.org/10.1158/1535-7163.c.6539608.v1
https://doi.org/10.1158/1535-7163.c.6539608.v1