Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mark A. Castanares"'
Autor:
Dongling Fei, Weihua Shen, Shripad V. Bhagwat, Mark A. Castanares, Brian E. Mattioni, Sheng-Bin Peng, Cecilia Mur, Lisa Kindler, Almudena Rubio, Alfonso De Dios, Jolie Anne Bastian, Baohui Zhao, Thomas K. Baker, Robert J. Barr, Maria Jose Lallena, Jason Manro, Eunice Yuen, Jeffrey Daniel Cohen
Publikováno v:
Cancer Research. 81:1236-1236
Nearly 70% of newly diagnosed breast cancers are estrogen receptor alpha (ERα) positive, for which endocrine therapy is a primary treatment. However, approximately 40% of those patients on endocrine therapy develop resistance, which includes mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b298f3744554131d5c141f569fd34f35
https://doi.org/10.1158/1538-7445.am2021-1236
https://doi.org/10.1158/1538-7445.am2021-1236
Publikováno v:
Molecular pharmaceutics. 16(5)
Tumor microenvironment is a significant physical barrier to the effective delivery of chemotherapy into solid tumors. To overcome this challenge, tumors are pretreated with an agent that reduces cellular and extracellular matrix densities prior to ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d524dc483cfc29d0a12478364118de7e
https://pubmed.ncbi.nlm.nih.gov/30916974
https://pubmed.ncbi.nlm.nih.gov/30916974
Autor:
Alexander Wei, Yoon Yeo, Sara A. Abouelmagd, Naveen Reddy Kadasala, Mark A. Castanares, David S. Collins, Jinho Park
Publikováno v:
Biomaterials. 101:285-295
Nanoparticle (NP)-based approaches to cancer drug delivery are challenged by the heterogeneity of the enhanced permeability and retention (EPR) effect in tumors and the premature attrition of payload from drug carriers during circulation. Here we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94461ae254c189e5c678a7223a4a3b27
https://doi.org/10.1016/j.biomaterials.2016.06.007
https://doi.org/10.1016/j.biomaterials.2016.06.007
For polymeric nanoparticles (NPs) to deliver more drugs to tumors than free drug solution, it is critical that the NPs establish interactions with tumor cells and avoid removal from the tumors. Since traditional polyethylene glycol (PEG) surface laye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bc34b36dbf2d2c92a888eaafad0515
https://europepmc.org/articles/PMC5722701/
https://europepmc.org/articles/PMC5722701/
Autor:
Greg Donoho, Jennifer R. Stephens, Mark A. Castanares, Christoph Reinhard, Karsten Boehnke, Aimee Lin, Wenjuan Wu, Jack A. Dempsey, Andrew Capen, Philip W. Iversen
Publikováno v:
Cancer Research. 79:3508-3508
TNBC, the most aggressive subtype of breast cancer, is characterized by high level of genomic instability, defects in DNA damage response (DDR) and increased replication stress (RS). The current treatment options for TNBC are limited and new approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d12c438c368f4bb866cf5b01bd668a4
https://doi.org/10.1158/1538-7445.am2019-3508
https://doi.org/10.1158/1538-7445.am2019-3508
Autor:
Christoph Reinhard, Constance King, Mark A. Castanares, Gregory P. Donoho, Ricardo Martinez, Andrew Capen, Richard P. Beckmann, Susan E. Pratt, Sean Buchanan, Wenjuan Wu, Yan Ding, Aimee Lin, Jennifer R. Stephens, Philip W. Iversen
Publikováno v:
Cancer Research. 78:336-336
Triple-negative breast cancer (TNBC), the most aggressive subtype of breast cancer, is diagnosed in approximately 15% of all breast cancer patients and characterized by high level of genomic instability, defects in DNA damage response (DDR) and incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fa5b08a15a4f191ad69ca6d5acf1dee
https://doi.org/10.1158/1538-7445.am2018-336
https://doi.org/10.1158/1538-7445.am2018-336
Autor:
Mark A, Castanares, Ben T, Copeland, Wasim H, Chowdhury, Minzhi M, Liu, Ronald, Rodriguez, Martin G, Pomper, Shawn E, Lupold, Catherine A, Foss
Publikováno v:
The Prostate. 76(2)
The LNCaP cell line was originally isolated from the lymph node of a patient with metastatic prostate cancer. Many cell lines have been derived from LNCaP by selective pressures to study different aspects of prostate cancer progression. When injected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0c98d4f0489bcecbd504f668de4d0847
https://pubmed.ncbi.nlm.nih.gov/26499105
https://pubmed.ncbi.nlm.nih.gov/26499105