Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mark A. Brimble"'
Autor:
Mark A. Brimble, Stephen M. Winston
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101336- (2024)
Externí odkaz:
https://doaj.org/article/363550614638441c96cb360fca94d1d8
Autor:
Gurdeep Singh, Gilda Stefanelli, Klotilda Narkaj, Mark A. Brimble, Samantha D. Creighton, Timothy A. B. McLean, Meaghan Hall, Krista A. Mitchnick, Jacqueline Zakaria, Thanh Phung, Anas Reda, Amanda M. Leonetti, Ashley Monks, Lara Ianov, Boyer D. Winters, Brandon J. Walters, Andrew M. Davidoff, Jennifer A. Mitchell, Iva B. Zovkic
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
The structurally-unique histone variant, mH2A1, influences learning and memory in mice to a greater extent than a similar variant, mH2A2.
Externí odkaz:
https://doaj.org/article/d840a5d938684f1fae4467b25c62e8a3
Autor:
Mark A. Brimble, Pei-Hsin Cheng, Stephen M. Winston, Isaiah L. Reeves, Aisha Souquette, Yunyu Spence, Junfang Zhou, Yong-Dong Wang, Christopher L. Morton, Marcus Valentine, Paul G. Thomas, Amit C. Nathwani, John T. Gray, Andrew M. Davidoff
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 280-291 (2022)
Recombinant adeno-associated virus (rAAV) vectors are increasingly being used for clinical gene transfer and have shown great potential for the treatment of several monogenic disorders. However, contaminant DNA from producer plasmids can be packaged
Externí odkaz:
https://doaj.org/article/9ce90bd19a374a6086d2a19259d8a399
Autor:
Gurdeep Singh, Gilda Stefanelli, Klotilda Narkaj, Mark A. Brimble, Samantha D. Creighton, Timothy A. B. McLean, Meaghan Hall, Krista A. Mitchnick, Jacqueline Zakaria, Thanh Phung, Anas Reda, Amanda M. Leonetti, Ashley Monks, Lara Ianov, Boyer D. Winters, Brandon J. Walters, Andrew M. Davidoff, Jennifer A. Mitchell, Iva B. Zovkic
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/a2cbb085173249b3b824b77e9b19d7bc
Autor:
Gilda Stefanelli, Amber B. Azam, Brandon J. Walters, Mark A. Brimble, Caroline P. Gettens, Pascale Bouchard-Cannon, Hai-Ying M. Cheng, Andrew M. Davidoff, Klotilda Narkaj, Jeremy J. Day, Andrew J. Kennedy, Iva B. Zovkic
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1124-1131 (2018)
Summary: Histone variants were recently discovered to regulate neural plasticity, with H2A.Z emerging as a memory suppressor. Using whole-genome sequencing of the mouse hippocampus, we show that basal H2A.Z occupancy is positively associated with ste
Externí odkaz:
https://doaj.org/article/9c12da0205304d89b9ae92c1b0d9e7ab
Autor:
Abdessattar Khlaifia, Mark A. Brimble, Maithe Arruda-Carvalho, Brandon J. Walters, Helen E. Scharfman, Justin J. Botterill
Adeno-associated viruses (AAVs) are a commonly used tool in neuroscience to efficiently label, trace, and/or manipulate neuronal populations. Highly specific targeting can be achieved through recombinase-dependent AAVs in combination with transgenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07db63725c1f339af5f3b5f32a2a5d42
https://doi.org/10.1101/2021.09.08.459310
https://doi.org/10.1101/2021.09.08.459310
Autor:
Meaghan Hall, Mark A. Brimble, Andrew M. Davidoff, Brandon J. Walters, Iva B. Zovkic, Timothy A.B. McLean, Celeste B. Greer, Anas Reda, Amanda M. Leonetti, Patrick J. Murphy, Jacqueline M. Zakaria, Jennet Baumbach, Samantha D. Creighton, Gilda Stefanelli, Claire E. Makowski
Publikováno v:
Cell reports
SUMMARY Rapid removal of histone H2A.Z from neuronal chromatin is a key step in learning-induced gene expression and memory formation, but mechanisms underlying learning-induced H2A.Z removal are unclear. Anp32e was recently identified as an H2A.Z-sp
Autor:
Bradley J Walters, Charles Askew, Andrew M. Davidoff, Graham R. Casey, R. Jude Samulski, Mark A. Brimble, Chengwen Li
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0242599 (2020)
PLoS ONE, Vol 15, Iss 11, p e0242599 (2020)
Sensorineural hearing loss is one of the most common disabilities worldwide. Such prevalence necessitates effective tools for studying the molecular workings of cochlear cells. One prominent and effective vector for expressing genes of interest in re
Autor:
Jun J. Yang, Dongli Hu, Pei-Hsin Cheng, Nicolas T. Gamboa, Ahmed Abu-Zaid, Gerard P. Zambetti, Kyle M. Miller, Taosheng Chen, Bingmei Sun, Mark A. Brimble, Yingdi Wang, Lance E. Palmer, Carolyn M Jablonowski, Guolian Kang, David Yanishevski, Yiping Fan, Chunliang Li, Qin Yan, Alaa Altahan, Ramhari Kumbhar, Andrew M. Davidoff, Cuixia Lan
Publikováno v:
iScience
iScience, Vol 9, Iss, Pp 84-100 (2018)
iScience, Vol 9, Iss, Pp 84-100 (2018)
Summary The p53 tumor suppressor pathway is frequently inactivated in human cancers. However, there are some cancer types without commonly recognized alterations in p53 signaling. Here we report that histone demethylase KDM5A is involved in the regul
Autor:
Andrew J. Kennedy, Caroline P. Gettens, Brandon J. Walters, Pascale Bouchard-Cannon, Klotilda Narkaj, Gilda Stefanelli, Mark A. Brimble, Hai-Ying M. Cheng, Jeremy J. Day, Iva B. Zovkic, Andrew M. Davidoff, Amber B. Azam
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1124-1131 (2018)
Summary: Histone variants were recently discovered to regulate neural plasticity, with H2A.Z emerging as a memory suppressor. Using whole-genome sequencing of the mouse hippocampus, we show that basal H2A.Z occupancy is positively associated with ste