Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Mark A. van de Wiel"'
Autor:
Tara Muijlwijk, Irene H. Nauta, Anabel van der Lee, Kari J. T. Grünewald, Arjen Brink, Sonja H. Ganzevles, Robert J. Baatenburg de Jong, Lilit Atanesyan, Suvi Savola, Mark A. van de Wiel, Laura A. N. Peferoen, Elisabeth Bloemena, Rieneke van de Ven, C. René Leemans, Jos B. Poell, Ruud H. Brakenhoff
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Cancer is caused by an accumulation of somatic mutations and copy number alterations (CNAs). Besides mutations, these copy number changes are key characteristics of cancer development. Nonetheless, some tumors show hardly any CNAs, a remarka
Externí odkaz:
https://doaj.org/article/225436245a4a4f2badda609a77918405
Autor:
Edgar E. Nollet, Sila Algül, Max Goebel, Saskia Schlossarek, Nicole N. van der Wel, Judith J.M. Jans, Mark A. van de Wiel, Jaco C. Knol, Thang V. Pham, Sander R. Piersma, Richard de Goeij-de Haas, Jill Hermans, Jan Bert van Klinken, Michel van Weeghel, Riekelt H. Houtkooper, Lucie Carrier, Connie R. Jimenez, Diederik W.D. Kuster, Jolanda van der Velden
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 6, Iss , Pp 100050- (2023)
Background and aim: Phenotypic expression of hypertrophic cardiomyopathy (HCM) and disease course are associated with unfavorable metabolic health. We investigated if Western diet (WD) feeding is sufficient to trigger cardiac hypertrophy and dysfunct
Externí odkaz:
https://doaj.org/article/a35423357cb242d7a31ba3d7bed60292
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background High-dimensional prediction considers data with more variables than samples. Generic research goals are to find the best predictor or to select variables. Results may be improved by exploiting prior information in the form of co-d
Externí odkaz:
https://doaj.org/article/c8511c0c447a42eead31e2144a052082
Autor:
Sander Bach, Birgit M.M. Wever, Mark A. van de Wiel, Joris D. Veltman, Sayed M.S. Hashemi, Geert Kazemier, Idris Bahce, Renske D.M. Steenbergen
Publikováno v:
Epigenetics, Vol 17, Iss 10, Pp 1057-1069 (2022)
High levels of methylated DNA in urine represent an emerging biomarker for non-small cell lung cancer (NSCLC) detection and are the subject of ongoing research. This study aimed to investigate the circadian variation of urinary cell-free DNA (cfDNA)
Externí odkaz:
https://doaj.org/article/e7ac72917cc64fc09d286d4eae550d70
Autor:
Bárbara Andrade Barbosa, Saskia D. van Asten, Ji Won Oh, Arantza Farina-Sarasqueta, Joanne Verheij, Frederike Dijk, Hanneke W. M. van Laarhoven, Bauke Ylstra, Juan J. Garcia Vallejo, Mark A. van de Wiel, Yongsoo Kim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Deconvolution methods reveal individual cell types in complex tissues profiled by bulk methods. Here the authors present a Bayesian deconvolution method that outperforms existing methods when benchmarked on >700 datasets, especially in estimating cel
Externí odkaz:
https://doaj.org/article/ab00233eafcc4cf68cdbf4b21d5d6744
Autor:
Bharati Jadhav, Ramin Monajemi, Kristina K. Gagalova, Daniel Ho, Harmen H. M. Draisma, Mark A. van de Wiel, Lude Franke, Bastiaan T. Heijmans, Joyce van Meurs, Rick Jansen, GoNL Consortium, BIOS Consortium, Peter A. C. ‘t Hoen, Andrew J. Sharp, Szymon M. Kiełbasa
Publikováno v:
BMC Biology, Vol 17, Iss 1, Pp 1-20 (2019)
Abstract Background Identification of imprinted genes, demonstrating a consistent preference towards the paternal or maternal allelic expression, is important for the understanding of gene expression regulation during embryonic development and of the
Externí odkaz:
https://doaj.org/article/ac49695a15374f9b92412458d4082fc2
Autor:
Dennis E. te Beest, Steven W. Mes, Saskia M. Wilting, Ruud H. Brakenhoff, Mark A. van de Wiel
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background Prediction in high dimensional settings is difficult due to the large number of variables relative to the sample size. We demonstrate how auxiliary ‘co-data’ can be used to improve the performance of a Random Forest in such a
Externí odkaz:
https://doaj.org/article/52ce1c17a9c44150b256b3245b12ee22
Autor:
Maike Schuldt, Beau van Driel, Sila Algül, Rahana Y. Parbhudayal, Daniela Q. C. M. Barge-Schaapveld, Ahmet Güçlü, Mark Jansen, Michelle Michels, Annette F. Baas, Mark A. van de Wiel, Max Nieuwdorp, Evgeni Levin, Tjeerd Germans, Judith J. M. Jans, Jolanda van der Velden
Publikováno v:
Cells, Vol 10, Iss 11, p 2950 (2021)
Hypertrophic Cardiomyopathy (HCM) is a common inherited heart disease with poor risk prediction due to incomplete penetrance and a lack of clear genotype–phenotype correlations. Advanced imaging techniques have shown altered myocardial energetics a
Externí odkaz:
https://doaj.org/article/a9ba77202bd64ddd8d0b7f6a3dbc9ef4
Publikováno v:
BMC Medical Research Methodology, Vol 17, Iss 1, Pp 1-12 (2017)
Abstract Background Multiple imputation is a recommended method to handle missing data. For significance testing after multiple imputation, Rubin’s Rules (RR) are easily applied to pool parameter estimates. In a logistic regression model, to consid
Externí odkaz:
https://doaj.org/article/c842923f1b2a4299a2180d015729decd
Autor:
Gerrit A. Meijer, Manon van Engeland, Chris J.J. Mulder, Philip Quirke, Silvia Sanduleanu, Adriaan P. de Bruïne, Tomio Arai, Bjorn J. Rembacken, Heike Grabsch, Martin Kliment, Bauke Ylstra, Ekaterina S. Jordanova, Mark A. van de Wiel, Eveline J.A. Rondagh, Sandra Mongera, Nicole C.T. van Grieken, Angela J. Spiertz, Beatriz Carvalho, Quirinus J.M. Voorham
PDF file, 4178K, Frequency plot of different subtypes, dysplasia, origin, gender, age and location.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580259ef20761a213296ef7c088bcac5
https://doi.org/10.1158/1078-0432.22447203.v1
https://doi.org/10.1158/1078-0432.22447203.v1
