Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Mark A van de Wiel"'
Autor:
Tara Muijlwijk, Irene H. Nauta, Anabel van der Lee, Kari J. T. Grünewald, Arjen Brink, Sonja H. Ganzevles, Robert J. Baatenburg de Jong, Lilit Atanesyan, Suvi Savola, Mark A. van de Wiel, Laura A. N. Peferoen, Elisabeth Bloemena, Rieneke van de Ven, C. René Leemans, Jos B. Poell, Ruud H. Brakenhoff
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Cancer is caused by an accumulation of somatic mutations and copy number alterations (CNAs). Besides mutations, these copy number changes are key characteristics of cancer development. Nonetheless, some tumors show hardly any CNAs, a remarka
Externí odkaz:
https://doaj.org/article/225436245a4a4f2badda609a77918405
Autor:
Maarten Neerincx, Dennis Poel, Daoud L S Sie, Nicole C T van Grieken, Ram C Shankaraiah, Floor S W van der Wolf-de Lijster, Jan-Hein T M van Waesberghe, Jan-Dirk Burggraaf, Paul P Eijk, Cornelis Verhoef, Bauke Ylstra, Gerrit A Meijer, Mark A van de Wiel, Tineke E Buffart, Henk M W Verheul
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201809 (2018)
BACKGROUND:First line chemotherapy is effective in 75 to 80% of patients with metastatic colorectal cancer (mCRC). We studied whether microRNA (miR) expression profiles can predict treatment outcome for first line fluoropyrimidine containing systemic
Externí odkaz:
https://doaj.org/article/565afe6c0e7f466f9639d433649f1fad
Autor:
Askar Obulkasim, Mark A van de Wiel
Publikováno v:
Cancer Informatics, Vol 2014, Iss 13, Pp 1-11 (2014)
Externí odkaz:
https://doaj.org/article/29407ed8fda04e2dabbadb1fcdb9ac6d
High Prevalence and Clinical Relevance of Genes Affected by Chromosomal Breaks in Colorectal Cancer.
Autor:
Evert van den Broek, Maurits J J Dijkstra, Oscar Krijgsman, Daoud Sie, Josien C Haan, Joleen J H Traets, Mark A van de Wiel, Iris D Nagtegaal, Cornelis J A Punt, Beatriz Carvalho, Bauke Ylstra, Sanne Abeln, Gerrit A Meijer, Remond J A Fijneman
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138141 (2015)
Cancer is caused by somatic DNA alterations such as gene point mutations, DNA copy number aberrations (CNA) and structural variants (SVs). Genome-wide analyses of SVs in large sample series with well-documented clinical information are still scarce.
Externí odkaz:
https://doaj.org/article/fabc696979d24c22ae1c2ca895da5a61
Autor:
Quirinus J M Voorham, Beatriz Carvalho, Angela J Spiertz, Bart Claes, Sandra Mongera, Nicole C T van Grieken, Heike Grabsch, Martin Kliment, Bjorn Rembacken, Mark A van de Wiel, Philip Quirke, Chris J J Mulder, Diether Lambrechts, Manon van Engeland, Gerrit A Meijer
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41963 (2012)
Flat adenomas are a subgroup of colorectal adenomas that have been associated with a distinct biology and a more aggressive clinical behavior compared to their polypoid counterparts. In the present study, we aimed to compare the mutation spectrum of
Externí odkaz:
https://doaj.org/article/d298f48868594ce39b9d0446625edc7f
Autor:
Edgar E. Nollet, Sila Algül, Max Goebel, Saskia Schlossarek, Nicole N. van der Wel, Judith J.M. Jans, Mark A. van de Wiel, Jaco C. Knol, Thang V. Pham, Sander R. Piersma, Richard de Goeij-de Haas, Jill Hermans, Jan Bert van Klinken, Michel van Weeghel, Riekelt H. Houtkooper, Lucie Carrier, Connie R. Jimenez, Diederik W.D. Kuster, Jolanda van der Velden
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 6, Iss , Pp 100050- (2023)
Background and aim: Phenotypic expression of hypertrophic cardiomyopathy (HCM) and disease course are associated with unfavorable metabolic health. We investigated if Western diet (WD) feeding is sufficient to trigger cardiac hypertrophy and dysfunct
Externí odkaz:
https://doaj.org/article/a35423357cb242d7a31ba3d7bed60292
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background High-dimensional prediction considers data with more variables than samples. Generic research goals are to find the best predictor or to select variables. Results may be improved by exploiting prior information in the form of co-d
Externí odkaz:
https://doaj.org/article/c8511c0c447a42eead31e2144a052082
Autor:
Sander Bach, Birgit M.M. Wever, Mark A. van de Wiel, Joris D. Veltman, Sayed M.S. Hashemi, Geert Kazemier, Idris Bahce, Renske D.M. Steenbergen
Publikováno v:
Epigenetics, Vol 17, Iss 10, Pp 1057-1069 (2022)
High levels of methylated DNA in urine represent an emerging biomarker for non-small cell lung cancer (NSCLC) detection and are the subject of ongoing research. This study aimed to investigate the circadian variation of urinary cell-free DNA (cfDNA)
Externí odkaz:
https://doaj.org/article/e7ac72917cc64fc09d286d4eae550d70
Autor:
Bárbara Andrade Barbosa, Saskia D. van Asten, Ji Won Oh, Arantza Farina-Sarasqueta, Joanne Verheij, Frederike Dijk, Hanneke W. M. van Laarhoven, Bauke Ylstra, Juan J. Garcia Vallejo, Mark A. van de Wiel, Yongsoo Kim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Deconvolution methods reveal individual cell types in complex tissues profiled by bulk methods. Here the authors present a Bayesian deconvolution method that outperforms existing methods when benchmarked on >700 datasets, especially in estimating cel
Externí odkaz:
https://doaj.org/article/ab00233eafcc4cf68cdbf4b21d5d6744
Autor:
Amélie V. Bos, Melissa M. J. van Gool, Annelot C. Breedveld, Richard van der Mast, Casper Marsman, Gerd Bouma, Mark A. van de Wiel, S. Marieke van Ham, Reina E. Mebius, Marjolein van Egmond
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11132 (2022)
Patients with inflammatory bowel disease (IBD) produce enhanced immunoglobulin A (IgA) against the microbiota compared to healthy individuals, which has been correlated with disease severity. Since IgA complexes can potently activate myeloid cells vi
Externí odkaz:
https://doaj.org/article/b81cc5c4bcbf4d498dbb4466725d221c