Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Mark A Zern"'
Autor:
Jong Ryeol Eun, Yong Jin Jung, Yanling Zhang, Yanhong Zhang, Benjamin Tschudy-Seney, Rajen Ramsamooj, Yu-Jui Yvonne Wan, Neil D Theise, Mark A Zern, Yuyou Duan
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110744 (2014)
SK Hep-1 cells (SK cells) derived from a patient with liver adenocarcinoma have been considered a human hepatoma cell line with mesenchymal origin characteristics, however, SK cells do not express liver genes and exhibit liver function, thus, we hypo
Externí odkaz:
https://doaj.org/article/0e9f390880db49a3b8b4eb6fb7368afe
Autor:
Wei Gao, Ping Zhou, Xiaocui Ma, Benjamin Tschudy-Seney, Jiamei Chen, Nataly L Magner, Alexander Revzin, Jan A Nolta, Mark A Zern, Yuyou Duan
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112698 (2014)
Alcohol insult triggers complex events in the liver, promoting fibrogenic/inflammatory signals and in more advanced cases, aberrant matrix deposition. It is well accepted that the regenerative capacity of the adult liver is impaired during alcohol in
Externí odkaz:
https://doaj.org/article/61324cd7e50b4bc5a9693e2733b8eaf9
Autor:
Ning Wang, Xiajing Li, Zhiyong Zhong, Yaqi Qiu, Shoupei Liu, Haibin Wu, Xianglian Tang, Chuxin Chen, Yingjie Fu, Qicong Chen, Tingting Guo, Jinsong Li, Shuai Zhang, Mark A. Zern, Keqiang Ma, Bailin Wang, Yimeng Ou, Weili Gu, Jie Cao, Honglin Chen, Yuyou Duan
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-26 (2021)
Abstract Background Exosomes secreted from stem cells exerted salutary effects on the fibrotic liver. Herein, the roles of exosomes derived from human embryonic stem cell (hESC) in anti-fibrosis were extensively investigated. Compared with two-dimens
Externí odkaz:
https://doaj.org/article/f73aea6404684e3bb56cbb6493d2d5f2
Autor:
Haibin Wu, Xianglian Tang, Yiyu Wang, Ning Wang, Qicong Chen, Jinghe Xie, Shoupei Liu, Zhiyong Zhong, Yaqi Qiu, Ping Situ, Mark A. Zern, Jue Wang, Honglin Chen, Yuyou Duan
Publikováno v:
Stem cell researchtherapy. 13(1)
Background Human pluripotent stem cells (hPSCs) have great potential in applications for regenerative medicine and drug development. However, 3D suspension culture systems for clinical-grade hPSC large-scale production have been a major challenge. Ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eeafcafb1aace372671ed563cc39c1d
https://pubmed.ncbi.nlm.nih.gov/35619172
https://pubmed.ncbi.nlm.nih.gov/35619172
Autor:
Chuxin Chen, Zhiyong Zhong, Qicong Chen, Weili Gu, Haibin Wu, Shuai Zhang, Xiajing Li, Honglin Chen, Yaqi Qiu, Bailin Wang, Shoupei Liu, Yimeng Ou, Yingjie Fu, Ning Wang, Mark A Zern, Keqing Ma, Yuyou Duan, Jie Cao, Xianglian Tang, Jinsong Li, Tingting Guo
Publikováno v:
Journal of Nanobiotechnology
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-26 (2021)
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-26 (2021)
Background Exosomes secreted from stem cells exerted salutary effects on the fibrotic liver. Herein, the roles of exosomes derived from human embryonic stem cell (hESC) in anti-fibrosis were extensively investigated. Compared with two-dimensional (2D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bede4d369dda1028ec2b65a242e4ac9
http://europepmc.org/articles/PMC8686281
http://europepmc.org/articles/PMC8686281
Autor:
Yuyou Duan, Honglin Chen, Yaqi Qiu, Jue Wang, Mark A. Zern, Liangxue Lai, Qicong Chen, Ping Situ, Xiajing Li, Haibin Wu, Zhiyong Zhong, Jinghe Xie, Ning Wang, Xianglian Tang
Publikováno v:
Cell Proliferation
Objectives For clinical applications of cell‐based therapies, a large quantity of human pluripotent stem cells (hPSCs) produced in standardized and scalable culture processes is required. Currently, microcarrier‐free suspension culture shows pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc75f60038f54075d0f3bce810206345
http://europepmc.org/articles/PMC8450127
http://europepmc.org/articles/PMC8450127
Publikováno v:
Liver International. 37:1260-1271
The liver is a unique organ for homoeostasis with regenerative capacities. Hepatocytes possess a remarkable capacity to proliferate upon injury; however, in more severe scenarios liver regeneration is believed to arise from at least one, if not sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4912bba04810b8eea9c153e3b90094
https://doi.org/10.1111/liv.13377
https://doi.org/10.1111/liv.13377
Publikováno v:
Cellular Signalling. 80:109925
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::317d9479186a4e42b8e92387d8d14968
https://doi.org/10.1016/j.cellsig.2021.109925
https://doi.org/10.1016/j.cellsig.2021.109925
Autor:
Jiamei Chen, Xiao Zhang, Cheng-Hai Liu, Yongping Mu, Ying Xu, Xuewei Li, Cheng Liu, Weiwei Fan, Ping Liu, Gaofeng Chen, Mark A. Zern, Guang-Li Du
Publikováno v:
Laboratory Investigation. 96:350-360
Although hepatic progenitor cells (HPCs) are known to contribute to cholestatic liver fibrosis (CLF), how Notch signaling modulates the differentiation of HPCs to cholangiocytes in CLF is unknown. Thus, using a rat model of CLF that is induced by bil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa271e1988decd1be3a342015d51409b
https://doi.org/10.1038/labinvest.2015.149
https://doi.org/10.1038/labinvest.2015.149
Publikováno v:
Stem cells and development, vol 27, iss 4
Hepatocytes differentiated from human embryonic stem cells (ESCs) could provide a powerful tool for enabling cell-based therapies, studying the mechanisms underlying human liver development and disease, and testing the efficacy and safety of pharmace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb242339f3167b7076ff02a3ee1e994
https://pubmed.ncbi.nlm.nih.gov/29256825
https://pubmed.ncbi.nlm.nih.gov/29256825