Zobrazeno 1 - 10
of 695
pro vyhledávání: '"Mark A Wainberg"'
Autor:
Anita Rachlis, Marianne Harris, Richard Lalonde, Stephen D Shafran, Cécile Tremblay, Mark A Wainberg, Sharon Walmsley
Publikováno v:
Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 21, Iss 4, Pp 159-172 (2010)
BACKGROUND AND OBJECTIVES: A Canadian group, consisting of six physicians and an HIV researcher with significant experience and knowledge in HIV management, reviewed the available data and developed guidelines for Canadian health care providers (who
Externí odkaz:
https://doaj.org/article/29af8fad739743de85d6ffd669937723
Autor:
Soo-Yon Rhee, Michael R Jordan, Elliot Raizes, Arlene Chua, Neil Parkin, Rami Kantor, Gert U Van Zyl, Irene Mukui, Mina C Hosseinipour, Lisa M Frenkel, Nicaise Ndembi, Raph L Hamers, Tobias F Rinke de Wit, Carole L Wallis, Ravindra K Gupta, Joseph Fokam, Clement Zeh, Jonathan M Schapiro, Sergio Carmona, David Katzenstein, Michele Tang, Avelin F Aghokeng, Tulio De Oliveira, Annemarie M J Wensing, Joel E Gallant, Mark A Wainberg, Douglas D Richman, Joseph E Fitzgibbon, Marco Schito, Silvia Bertagnolio, Chunfu Yang, Robert W Shafer
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145772 (2015)
The increasing prevalence of acquired and transmitted HIV-1 drug resistance is an obstacle to successful antiretroviral therapy (ART) in the low- and middle-income countries (LMICs) hardest hit by the HIV-1 pandemic. Genotypic drug resistance testing
Externí odkaz:
https://doaj.org/article/7187aebbffbc469893ba57022e00b398
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128310 (2015)
Understanding the HIV integrase protein and mechanisms of resistance to HIV integrase inhibitors is complicated by the lack of a full length HIV integrase crystal structure. Moreover, a lentiviral integrase structure with co-crystallised DNA has not
Externí odkaz:
https://doaj.org/article/d251431c5d4b4d68bddc6b3ba8585b8f
Autor:
Hugues Charest, Florence Doualla-Bell, Régis Cantin, Donald G Murphy, Linda Lemieux, Bluma Brenner, Isabelle Hardy, Daniela Moisi, Ernest Lo, Jean-Guy Baril, Mark A Wainberg, Michel Roger, Cécile Tremblay
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109420 (2014)
BACKGROUND: HIV drug resistance represents a major threat for effective treatment. We assessed the trends in the frequency of drug resistance mutations and the monitored viral load (VL) in treatment-naïve (TN) and treatment-experienced (TE) individu
Externí odkaz:
https://doaj.org/article/6254111eabc444bfadaf8c71d3af8fd5
Autor:
Björn D Kuhl, Vicky Cheng, Daniel A Donahue, Richard D Sloan, Chen Liang, John Wilkinson, Mark A Wainberg
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27660 (2011)
Among its many roles, the HIV-1 accessory protein Vpu performs a viroporin function and also antagonizes the host cell restriction factor tetherin through its transmembrane domain. BIT225 is a small molecule inhibitor that specifically targets the Vp
Externí odkaz:
https://doaj.org/article/41648ef9c33c4eeab16183c0fb71a58d
Autor:
Dimitrios Coutsinos, Cédric F Invernizzi, Daniela Moisi, Maureen Oliveira, Jorge L Martinez-Cajas, Bluma G Brenner, Mark A Wainberg
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20208 (2011)
Numerous studies have suggested that the K65R reverse transcriptase (RT) mutation develops more readily in subtype C than subtype B HIV-1. We recently showed that this discrepancy lies partly in the subtype C template coding sequence that predisposes
Externí odkaz:
https://doaj.org/article/3ad80219ff8e4994934de1dc91c91d18
Autor:
Anita Rachlis, Jonathan B Angel, Marianne Harris, Stephen D Shafran, Rachel Therrien, Cécile Tremblay, Mark A Wainberg
Publikováno v:
Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 20, Iss 3, Pp e67-e80 (2009)
BACKGROUND AND OBJECTIVES: A meeting of a Canadian group with significant experience and knowledge in HIV management, consisting of five physicians, a pharmacist and an AIDS researcher, was convened. Their goal was to develop guidance for Canadian HI
Externí odkaz:
https://doaj.org/article/0653f2f65e0b4f96aa6ea842cabf811d
Autor:
Mark A Wainberg, Ronald Rooke, Michel Tremblay, XuGuang Li, Michael A Parniak, Qing Gao, Xiao-Jian Yao, Chris Tsoukas, JSG Montaner, M Fanning, J Ruedy
Publikováno v:
Canadian Journal of Infectious Diseases, Vol 2, Iss 1, Pp 5-11 (1991)
A number of laboratories have now independently confirmed that zidovudine (AZT)-resistant strains of human immunodeficiency virus type 1 (HIV-1) may be isolated from patients undergoing prolonged therapy with this drug. In certain instances, such dru
Externí odkaz:
https://doaj.org/article/c25b69d438b441e4af8bd9ebcb8d9767
Publikováno v:
Canadian Journal of Infectious Diseases, Vol 2, Iss 3, Pp 121-128 (1991)
The replication cycle of human immunodeficiency virus type 1 (HIV-1) and other retroviruses consists of four stages: attachment of the virus to specific receptors on the cell surface; uncoating of the viral nucleic acid and conversion to DNA; product
Externí odkaz:
https://doaj.org/article/d0423e72d50b4f509afe208a52013454
Autor:
Inge Derdelinckx, Mark A Wainberg, Joep M A Lange, Andrew Hill, Yasmin Halima, Charles A B Boucher
Publikováno v:
PLoS Medicine, Vol 3, Iss 11, p e454 (2006)
Externí odkaz:
https://doaj.org/article/afe956ed74a649ddaa896d1c767057a0