Zobrazeno 1 - 10
of 5 467
pro vyhledávání: '"Mark A Smith"'
Publikováno v:
Journal of Chromatography Open, Vol 5, Iss , Pp 100127- (2024)
Faba bean is an emerging pulse crop for the Canada Prairies and is becoming an increasingly important source of plant sourced protein. It also has a high content of levodopa (up to 0.1 % of the dry seed weight), a nutraceutical compound for treating
Externí odkaz:
https://doaj.org/article/b2aa6c897a164b73824fb8ca0331cb0e
Autor:
Sonia R Rosner, Christopher D Pascoe, Elizabeth Blankman, Christopher C Jensen, Ramaswamy Krishnan, Alan L James, John G Elliot, Francis H Green, Jeffrey C Liu, Chun Y Seow, Jin-Ah Park, Mary C Beckerle, Peter D Paré, Jeffrey J Fredberg, Mark A Smith
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0171728 (2017)
Bronchospasm induced in non-asthmatic human subjects can be easily reversed by a deep inspiration (DI) whereas bronchospasm that occurs spontaneously in asthmatic subjects cannot. This physiological effect of a DI has been attributed to the manner in
Externí odkaz:
https://doaj.org/article/1629d355381e4d5cb818f4e71db3807d
Autor:
Mark A Smith, Elizabeth Blankman, Nicholas O Deakin, Laura M Hoffman, Christopher C Jensen, Christopher E Turner, Mary C Beckerle
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e69378 (2013)
Contractile actomyosin stress fibers are critical for maintaining the force balance between the interior of the cell and its environment. Consequently, the actin cytoskeleton undergoes dynamic mechanical loading. This results in spontaneous, stochast
Externí odkaz:
https://doaj.org/article/36258c244ec34ebea41f4a2205c889b9
Autor:
Alyssa D Flora, Louise D Teel, Mark A Smith, James F Sinclair, Angela R Melton-Celsa, Alison D O'Brien
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69706 (2013)
Ricin is a potent toxin found in the beans of Ricinus communis and is often lethal for animals and humans when aerosolized or injected and causes significant morbidity and occasional death when ingested. Ricin has been proposed as a bioweapon because
Externí odkaz:
https://doaj.org/article/35b80b56f0ae4312b1d97cf3c6998429
Autor:
Hyun-Pil Lee, Neel Pancholi, Luke Esposito, Laura A Previll, Xinglong Wang, Xiongwei Zhu, Mark A Smith, Hyoung-gon Lee
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e28033 (2012)
While oxidative stress has been linked to Alzheimer's disease, the underlying pathophysiological relationship is unclear. To examine this relationship, we induced oxidative stress through the genetic ablation of one copy of mitochondrial antioxidant
Externí odkaz:
https://doaj.org/article/a1ec3c3d99a44a63b78e7e17dfc74d3e
Autor:
Yiyuan Yuan, Pengxiu Cao, Mark A Smith, Kristopher Kramp, Ying Huang, Naoki Hisamoto, Kunihiro Matsumoto, Maria Hatzoglou, Hui Jin, Zhaoyang Feng
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22354 (2011)
Mutation of leucine-rich repeat kinase 2 (LRRK2) is the leading genetic cause of Parkinson's Disease (PD), manifested as age-dependent dopaminergic neurodegeneration, but the underlying molecular mechanisms remain unclear. Multiple roles of LRRK2 may
Externí odkaz:
https://doaj.org/article/1b56426367c34cfa88414ff253b1203b
Autor:
Sónia C Correia, Cristina Carvalho, Susana Cardoso, Renato X Santos, Maria S Santos, Catarina Oliveira, George Perry, Xiongwei Zhu, Mark A Smith, Paula I Moreira
Publikováno v:
Frontiers in Aging Neuroscience, Vol 2 (2010)
Mitochondria have long been known as the powerhouse of the cell. However, these organelles are also pivotal players in neuronal cell death. Mitochondrial dysfunction is a prominent feature of chronic brain disorders, including Alzheimer's and Parkins
Externí odkaz:
https://doaj.org/article/34d6ec0a4c68492db943f8efa777f10a
Autor:
Thomas W Geisbert, Kathleen M Daddario-DiCaprio, Andrew C Hickey, Mark A Smith, Yee-Peng Chan, Lin-Fa Wang, Joseph J Mattapallil, Joan B Geisbert, Katharine N Bossart, Christopher C Broder
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10690 (2010)
Nipah virus (NiV) is an enigmatic emerging pathogen that causes severe and often fatal neurologic and/or respiratory disease in both animals and humans. Amongst people, case fatality rates range between 40 and 75 percent and there are no vaccines or
Externí odkaz:
https://doaj.org/article/f6425e2de58443dbaed7bd3792730f16
Autor:
Burkhard Poeggeler, Kumar Sambamurti, Sandra L Siedlak, George Perry, Mark A Smith, Miguel A Pappolla
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10206 (2010)
Aging is a multi-factorial process, however, it is generally accepted that reactive oxygen species (ROS) are significant contributors. Mitochondria are important players in the aging process because they produce most of the cellular ROS. Despite the
Externí odkaz:
https://doaj.org/article/e1ff9db777884c4e92fc1765c2edc7aa
Autor:
Hyoung-gon Lee, Qun Chen, Julie A Wolfram, Sandy L Richardson, Anna Liner, Sandra L Siedlak, Xiongwei Zhu, Nicholas P Ziats, Hisashi Fujioka, Dean W Felsher, Rudy J Castellani, Maria L Valencik, John A McDonald, Brian D Hoit, Edward J Lesnefsky, Mark A Smith
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7172 (2009)
While considerable evidence supports the causal relationship between increases in c-Myc (Myc) and cardiomyopathy as a part of a "fetal re-expression" pattern, the functional role of Myc in mechanisms of cardiomyopathy remains unclear. To address this
Externí odkaz:
https://doaj.org/article/9ab82388ceff4f3d8d97745aec42e465