Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Mark A Le Gros"'
Autor:
Jingwei Ma, Myan Do, Mark A Le Gros, Charles S Peskin, Carolyn A Larabell, Yoichiro Mori, Samuel A Isaacson
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1008356 (2020)
For a chemical signal to propagate across a cell, it must navigate a tortuous environment involving a variety of organelle barriers. In this work we study mathematical models for a basic chemical signal, the arrival times at the nuclear membrane of p
Externí odkaz:
https://doaj.org/article/e684153658db454b9eee17439c2346d5
Autor:
Venera Weinhardt, Jian-Hua Chen, Axel A Ekman, Jessica Guo, Soumya G Remesh, Michal Hammel, Gerry McDermott, Weilun Chao, Sharon Oh, Mark A Le Gros, Carolyn A Larabell
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227601 (2020)
The diversity of living cells, in both size and internal complexity, calls for imaging methods with adaptable spatial resolution. Soft x-ray tomography (SXT) is a three-dimensional imaging technique ideally suited to visualizing and quantifying the i
Externí odkaz:
https://doaj.org/article/3df436e81ff942be8f8daf9bcf191b2d
Autor:
Arnold Y Seo, Pick-Wei Lau, Daniel Feliciano, Prabuddha Sengupta, Mark A Le Gros, Bertrand Cinquin, Carolyn A Larabell, Jennifer Lippincott-Schwartz
Publikováno v:
eLife, Vol 6 (2017)
Dietary restriction increases the longevity of many organisms, but the cell signaling and organellar mechanisms underlying this capability are unclear. We demonstrate that to permit long-term survival in response to sudden glucose depletion, yeast ce
Externí odkaz:
https://doaj.org/article/97654cfff0054f5ba9899b3ee15fcc10
Autor:
Axel Ekman, Jian-Hua Chen, Bieke Vanslembrouck, Valentina Loconte, Carolyn A. Larabell, Mark A. Le Gros, Venera Weinhardt
Publikováno v:
Advanced Photonics Research, Vol 4, Iss 4, Pp n/a-n/a (2023)
Soft X‐ray tomography offers rapid imaging of whole, single cells with a few tens of nanometers spatial resolution without fixation or labeling. Herein, this technique is limited to specimens about 10 μm thick, such that applications of soft X‐r
Externí odkaz:
https://doaj.org/article/34ab2b85a3cf4a76a5ee7c6e7e7cfd72
Autor:
Jian-Hua Chen, Bieke Vanslembrouck, Valentina Loconte, Axel Ekman, Mirko Cortese, Ralf Bartenschlager, Gerry McDermott, Carolyn A. Larabell, Mark A. Le Gros, Venera Weinhardt
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101176- (2022)
Summary: The protocol describes step-by-step sample preparation, data acquisition, and segmentation of cellular organelles with soft X-ray tomography. It is designed for microscopes built to perform full-rotation data acquisition on specimens in cyli
Externí odkaz:
https://doaj.org/article/2ffd46a8a2e34dd5ae9932cc02244dd6
Autor:
Jian-Hua Chen, Bieke Vanslembrouck, Axel Ekman, Vesa Aho, Carolyn A. Larabell, Mark A. Le Gros, Maija Vihinen-Ranta, Venera Weinhardt
Publikováno v:
Viruses, Vol 14, Iss 12, p 2651 (2022)
Upon infection, viruses hijack the cell machinery and remodel host cell structures to utilize them for viral proliferation. Since viruses are about a thousand times smaller than their host cells, imaging virus-host interactions at high spatial resolu
Externí odkaz:
https://doaj.org/article/7d1f06bf5cef4e51a946d69fcc3a9b36
Autor:
Emily M. Sontag, Fabián Morales-Polanco, Jian-Hua Chen, Gerry McDermott, Patrick T. Dolan, Daniel Gestaut, Mark A. Le Gros, Carolyn Larabell, Judith Frydman
Publikováno v:
Nature Cell Biology. 25:699-713
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34f2b78eafc39107d2c5ffec1fe71db2
https://doi.org/10.1038/s41556-023-01128-6
https://doi.org/10.1038/s41556-023-01128-6
Autor:
Valentina Loconte, Jian‐Hua Chen, Bieke Vanslembrouck, Axel A. Ekman, Gerry McDermott, Mark A. Le Gros, Carolyn A. Larabell
Publikováno v:
The FASEB Journal. 37
Developing in silico models that accurately reflect a whole, functional cell is an ongoing challenge in biology. Current efforts bring together mathematical models, probabilistic models, visual representations, and data to create a multi-scale descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15dd841f007c01586565e469c35c0e5
https://doi.org/10.1096/fj.202200253r
https://doi.org/10.1096/fj.202200253r
Autor:
Emily M. Sontag, Fabián Morales-Polanco, Jian-Hua Chen, Gerry McDermott, Patrick T. Dolan, Dan Gestaut, Mark A. Le Gros, Carolyn Larabell, Judith Frydman
Effective Protein Quality Control (PQC), essential for cellular health, relies on spatial sequestration of misfolded proteins into defined inclusions. Here we elucidate the coordination of nuclear and cytoplasmic spatial PQC. While cytoplasmic misfol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efcd6ca05161c4d8aabab9383c9f533f
https://doi.org/10.1101/2022.12.01.518779
https://doi.org/10.1101/2022.12.01.518779
Autor:
Axel Ekman, Jian-Hua Chen, Bieke Vanslembrouck, Carolyn A Larabell, Mark A Le Gros, Venera Weinhardt
Soft x-ray tomography offers rapid whole single cell imaging with a few tens of nanometers spatial resolution without fixation or labelling. At the moment, this technique is limited to 10 µm thick specimens, such that applications of soft x-ray tomo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2645d60f155302e2aee2c20093171f85
https://doi.org/10.1101/2022.05.11.491437
https://doi.org/10.1101/2022.05.11.491437