Ca2+‐activated Cl− channels (TMEM16A) underlie spontaneous electrical activity in isolated mouse corpus cavernosum smooth muscle cells

Autor: Xin Rui Lim, Bernard T. Drumm, Gerard P. Sergeant, Mark A. Hollywood, Keith D. Thornbury

Publikováno v: Physiological Reports, Vol 10, Iss 22, Pp n/a-n/a (2022)

Abstract Penile detumescence is maintained by tonic contraction of corpus cavernosum smooth muscle cells (CCSMC), but the underlying mechanisms have not been fully elucidated. The purpose of this study was to characterize the mechanisms underlying ac

Externí odkaz: https://doaj.org/article/65e14dfb4a29496c830ddbc1ddc76622

Blockade of Kv7 channels reverses the inhibitory effects of exchange protein directly activated by cAMP activation on purinergic contractions of the murine detrusor

Autor: Zhihui Fong, Anshika Lall, Nicolas D. Mullins, L. Fernando Santana, Mark A. Hollywood, Keith D. Thornbury, Gerard P. Sergeant

Publikováno v: Basic & Clinical Pharmacology & Toxicology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d31f9b2e8faa84763aaa00a290e4ecc7
https://doi.org/10.1111/bcpt.13881

Oxidation modulates LINGO2-induced inactivation of large conductance, Ca2+-activated potassium channels

Autor: Srikanth Dudem, Pei Xin Boon, Nicholas Mullins, Heather McClafferty, Michael J. Shipston, Richard D.A. Wilkinson, Ian Lobb, Gerard P. Sergeant, Keith D. Thornbury, Irina G. Tikhonova, Mark A. Hollywood

Publikováno v: Dudem, S, Boon, P X, Mullins, N, McClafferty, H, Shipston, M J, Wilkinson, R D A, Lobb, I, Sergeant, G P, Thornbury, K D, Tikhonova, I G & Hollywood, M A 2023, ' Oxidation modulates LINGO2-induced inactivation of large conductance, Ca2 +-activated potassium channels ', The Journal of Biological Chemistry, vol. 299, no. 3, 102975 . https://doi.org/10.1016/j.jbc.2023.102975

Ca 2+ and voltage-activated K + (BK) channels are ubiquitous ion channels that can be modulated by accessory proteins, including β, γ, and LINGO1 BK subunits. In this study, we utilized a combination of site-directed mutagenesis, patch clamp electr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1495f97e0c80f1b57baf1814ccbfd671
https://pure.qub.ac.uk/en/publications/5d33d0e5-f1db-494a-a1d1-cd824ca00826

Ca

Autor: Xin Rui, Lim, Bernard T, Drumm, Gerard P, Sergeant, Mark A, Hollywood, Keith D, Thornbury

Publikováno v: Physiological reportsREFERENCES. 10(22)

Penile detumescence is maintained by tonic contraction of corpus cavernosum smooth muscle cells (CCSMC), but the underlying mechanisms have not been fully elucidated. The purpose of this study was to characterize the mechanisms underlying activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aebbd26c1dfb83cd61c590109a470128
https://pubmed.ncbi.nlm.nih.gov/36394209

M2 Muscarinic Receptor-Dependent Contractions of Airway Smooth Muscle are Inhibited by Activation of β-Adrenoceptors

Autor: Tuleen Alkawadri, Pei Yee Wong, Zhihui Fong, Fionnuala T Lundy, Lorcan P McGarvey, Mark A Hollywood, Keith D Thornbury, Gerard P Sergeant

Publikováno v: Alkawadri, T, Wong, P Y, Fong, Z, Lundy, F T, McGarvey, L P, Hollywood, M A, Thornbury, K D & Sergeant, G P 2022, ' M2 muscarinic receptor-dependent contractions of airway smooth muscle are inhibited by activation of β-adrenoceptors ', Function, vol. 3, no. 6, zqac050 . https://doi.org/10.1093/function/zqac050

Beta-adrenoceptor (β-AR) agonists inhibit cholinergic contractions of airway smooth muscle (ASM), but the underlying mechanisms are unclear. ASM cells express M3 and M2 muscarinic receptors, but the bronchoconstrictor effects of acetylcholine are be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c77a792a818bebeb682c8c1caf55fa0
https://pubmed.ncbi.nlm.nih.gov/36325515