Zobrazeno 1 - 10
of 511
pro vyhledávání: '"Mark A Hill"'
Autor:
Sounak Sahu, Divya Sridhar, Prasad Abnave, Noboyoshi Kosaka, Anish Dattani, James M Thompson, Mark A Hill, Aziz Aboobaker
Publikováno v:
eLife, Vol 10 (2021)
Mechanical stress during cell migration may be a previously unappreciated source of genome instability, but the extent to which this happens in any animal in vivo remains unknown. We consider an in vivo system where the adult stem cells of planarian
Externí odkaz:
https://doaj.org/article/a2032e4a232a439c8381bd69453ce546
Autor:
Veerle Kersemans, John S Beech, Stuart Gilchrist, Paul Kinchesh, Philip D Allen, James Thompson, Ana L Gomes, Zenobia D'Costa, Luke Bird, Iain D C Tullis, Robert G Newman, Aurelien Corroyer-Dulmont, Nadia Falzone, Abul Azad, Katherine A Vallis, Owen J Sansom, Ruth J Muschel, Borivoj Vojnovic, Mark A Hill, Emmanouil Fokas, Sean C Smart
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176693 (2017)
Preclinical CT-guided radiotherapy platforms are increasingly used but the CT images are characterized by poor soft tissue contrast. The aim of this study was to develop a robust and accurate method of MRI-guided radiotherapy (MR-IGRT) delivery to ab
Externí odkaz:
https://doaj.org/article/ae518cca3a5a4ee6a6bf6b30edf910b8
Autor:
Robert E. Hynds, Ariana Huebner, David R. Pearce, Mark S. Hill, Ayse U. Akarca, David A. Moore, Sophia Ward, Kate H. C. Gowers, Takahiro Karasaki, Maise Al Bakir, Gareth A. Wilson, Oriol Pich, Carlos Martínez-Ruiz, A. S. Md Mukarram Hossain, Simon P. Pearce, Monica Sivakumar, Assma Ben Aissa, Eva Grönroos, Deepak Chandrasekharan, Krishna K. Kolluri, Rebecca Towns, Kaiwen Wang, Daniel E. Cook, Leticia Bosshard-Carter, Cristina Naceur-Lombardelli, Andrew J. Rowan, Selvaraju Veeriah, Kevin Litchfield, Philip A. J. Crosbie, Caroline Dive, Sergio A. Quezada, Sam M. Janes, Mariam Jamal-Hanjani, Teresa Marafioti, TRACERx consortium, Nicholas McGranahan, Charles Swanton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Patient-derived xenograft (PDX) models are widely used in cancer research. To investigate the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX models from 22 patients enrolled in the TRACERx study. Multi-regio
Externí odkaz:
https://doaj.org/article/15a9cb6171ca46d4a07fbfbe6bf74b76
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Phenotypic evolution is often caused by variation in gene expression resulting from altered gene regulatory mechanisms. Genetic variation affecting chromatin remodeling has been identified as a potential source of variable gene expression; h
Externí odkaz:
https://doaj.org/article/1a4d973dfc9a40edb40711bbf9e6700d
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4920 (2023)
Radiotherapy (ionising radiation; IR) is utilised in the treatment of ~50% of all human cancers, and where the therapeutic effect is largely achieved through DNA damage induction. In particular, complex DNA damage (CDD) containing two or more lesions
Externí odkaz:
https://doaj.org/article/b50a43ce9a664f25932eb4b0a1232318
Autor:
Victor M. Lu, Felicity Crawshay-Williams, Benjamin White, Amy Elliot, Mark A. Hill, Helen E. Townley
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 47, Iss 1, Pp 132-143 (2019)
Glioblastoma is a heterogeneous disease with multiple genotypic origins. Despite treatment protocols such as surgery, radiotherapy and chemotherapy, the prognosis for patients remains poor. This study investigates the cytotoxic and radiation dose-enh
Externí odkaz:
https://doaj.org/article/f5ddcb4f5230433d81a6dd39510d8aff
Autor:
Catherine M. Nickson, Maria Rita Fabbrizi, Rachel J. Carter, Jonathan R. Hughes, Andrzej Kacperek, Mark A. Hill, Jason L. Parsons
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Ionizing radiation (IR) principally acts through induction of DNA damage that promotes cell death, although the biological effects of IR are more broad ranging. In fact, the impact of IR of higher-linear energy transfer (LET) on cell biology is gener
Externí odkaz:
https://doaj.org/article/bc44de8955044d5e8a2b5d05e5752fa6
Autor:
John W. Hopewell, Joshua Moore, Conrad J. Villafuerte, Ian Paddick, Bleddyn Jones, Mark A. Hill, Derek S. Tsang
Publikováno v:
World Neurosurgery. 172:e130-e143
Objective To recalculate biological effective dose values (BED) for radio-surgical treatments of acoustic neuroma from a previous study. BEDs values were previously overestimated by only using beam-on times in calculations, so excluding the important
Autor:
Daniel S. Berger, Daniel Ernst, Huaicheng Li, Pantea Zardoshti, Monish Shah, Samir Rajadnya, Scott Lee, Lisa Hsu, Ishwar Agarwal, Mark D. Hill, Ricardo Bianchini
Publikováno v:
IEEE Micro. 43:30-38
DRAM is a key driver of performance and cost in public cloud servers. At the same time, a significant amount of DRAM is underutilized due to fragmented use across servers. Emerging interconnects such as CXL offer a path towards improving utilization
Autor:
Sara Brett, Aiman Shalabi, Dmitry Pankov, Ioanna Eleftheriadou, Anna Domogala, Lea Patasic, Magdalena Kijewska, Gary Thripp, Jack Euesden, Jan Klapwijk, Katrina Soor, Miriam Damm, Mark D Hill, Mirella Georgouli, Cedrik Britten
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/b87f9805237a4c37899aad3971a94956