Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Mark A Giembycz"'
Autor:
Tresa George, Matthew Bell, Mainak Chakraborty, David P Siderovski, Mark A Giembycz, Robert Newton
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170269 (2017)
The GTPase-accelerating protein, regulator of G-protein signalling 2 (RGS2) reduces signalling from G-protein-coupled receptors (GPCRs) that signal via Gαq. In humans, RGS2 expression is up-regulated by inhaled corticosteroids (ICSs) and long-acting
Externí odkaz:
https://doaj.org/article/572fe8d91a2047e4a7e647fc646c4bf5
Autor:
Mark A Giembycz, Stephen K Field
Publikováno v:
Drug Design, Development and Therapy, Vol 2010, Iss default, Pp 147-158 (2010)
Mark A Giembycz1, Stephen K Field2Departments of 1Physiology and Pharmacology and 2Medicine, Airway Inflammation Research Group, Faculty of Medicine, University of Calgary, Alberta, CanadaAbstract: In April 2010, the European Medicines Agency Committ
Externí odkaz:
https://doaj.org/article/ff76ce2c519e4a30a4bb00a345e0b3a9
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116773 (2015)
Acting on the glucocorticoid receptor (NR3C1), glucocorticoids are widely used to treat inflammatory diseases. However, glucocorticoid resistance often leads to suboptimal asthma control. Since glucocorticoid-induced gene expression contributes to gl
Externí odkaz:
https://doaj.org/article/75f36970dae643a6844edc1126f14280
Autor:
Hannu Kankaanranta, Pinja Ilmarinen, Xianzhi Zhang, Ian M Adcock, Aleksi Lahti, Peter J Barnes, Mark A Giembycz, Mark A Lindsay, Eeva Moilanen
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90298 (2014)
Eosinophils play a central role in asthma. The present study was performed to investigate the effect of tumour necrosis factor-α (TNF-α) on longevity of isolated human eosinophils. In contrast to Fas, TNF-α inhibited eosinophil apoptosis as eviden
Externí odkaz:
https://doaj.org/article/f75259eada954b268ec3bc232dad4907
Autor:
Mark A Lindsay, Mark A Giembycz
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 92, Pp 115-123 (1997)
Activation of the eosinophil NADPH oxidase and the subsequent release of toxic oxygen radicals has been implicated in the mechanism of parasite killing and inflammation. At present, little is known of the signal transduction pathway that govern agoni
Externí odkaz:
https://doaj.org/article/a82c3b615cf74f3da3d55e6abfc84865
Autor:
Elizabeth M King, Joanna E Chivers, Christopher F Rider, Anne Minnich, Mark A Giembycz, Robert Newton
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53936 (2013)
Binding of glucocorticoid to the glucocorticoid receptor (GR/NR3C1) may repress inflammatory gene transcription via direct, protein synthesis-independent processes (transrepression), or by activating transcription (transactivation) of multiple anti-i
Externí odkaz:
https://doaj.org/article/af55fea600b245048ca795fb24f2ed93
Publikováno v:
British Journal of Pharmacology. 179:4593-4614
It has been proposed that genomic mechanisms contribute to adverse effects often experienced by asthmatic subjects who take regular, inhaled βGene expression changes were determined by RNA-sequencing. Gene silencing and genome editing were employed
Publikováno v:
Molecular Pharmacology. 100:388-405
Chronic use of β2-adrenoceptor agonists as a monotherapy in asthma is associated with a loss of disease control and an increased risk of mortality. Herein, we tested the hypothesis that β2-adrenoceptor agonists, including formoterol, promote biased
Autor:
Omar Hamed, Mark A. Giembycz
Publikováno v:
The FASEB Journal. 36
Autor:
Mark A. Giembycz, Richard Leigh, Robert Newton, Mahmoud M. Mostafa, Christopher F. Rider, N. Dulmini Wathugala
Publikováno v:
Molecular Pharmacology. 99:197-216
In 2019, the Global Initiative for Asthma treatment guidelines were updated to recommend that inhaled corticosteroid (ICS)/long-acting β 2-adrenoceptor agonist (LABA) combination therapy should be a first-in-line treatment option for asthma. Althoug