Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mark A Durham"'
Autor:
Sameer S Bajikar, Ashley G Anderson, Jian Zhou, Mark A Durham, Alexander J Trostle, Ying-Wooi Wan, Zhandong Liu, Huda Y Zoghbi
Publikováno v:
eLife, Vol 12 (2023)
Loss- and gain-of-function of MeCP2 causes Rett syndrome (RTT) and MECP2 duplication syndrome (MDS), respectively. MeCP2 binds methyl-cytosines to finely tune gene expression in the brain, but identifying genes robustly regulated by MeCP2 has been di
Externí odkaz:
https://doaj.org/article/6b82cfcf999546bdac0e75edf2ab2c99
Autor:
Laura A Lavery, Kerstin Ure, Ying-Wooi Wan, Chongyuan Luo, Alexander J Trostle, Wei Wang, Haijing Jin, Joanna Lopez, Jacinta Lucero, Mark A Durham, Rosa Castanon, Joseph R Nery, Zhandong Liu, Margaret Goodell, Joseph R Ecker, M Margarita Behrens, Huda Y Zoghbi
Publikováno v:
eLife, Vol 9 (2020)
Methylated cytosine is an effector of epigenetic gene regulation. In the brain, Dnmt3a is the sole ‘writer’ of atypical non-CpG methylation (mCH), and MeCP2 is the only known ‘reader’ for mCH. We asked if MeCP2 is the sole reader for Dnmt3a d
Externí odkaz:
https://doaj.org/article/b078fc09c47f4ff18e2e3557478a806d
Autor:
Stephanie L. Coffin, Mark A. Durham, Larissa Nitschke, Eder Xhako, Amanda M. Brown, Jean-Pierre Revelli, Esmeralda Villavicencio Gonzalez, Tao Lin, Hillary P. Handler, Yanwan Dai, Alexander J. Trostle, Ying-Wooi Wan, Zhandong Liu, Roy V. Sillitoe, Harry T. Orr, Huda Y. Zoghbi
Publikováno v:
Neuron. 111:481-492.e8
Spinocerebellar ataxia type 1 (SCA1) is a paradigmatic neurodegenerative disease in that it is caused by a mutation in a broadly expressed protein, ATXN1; however, only select populations of cells degenerate. The interaction of polyglutamine-expanded
Autor:
Jian Zhou, Hamdan Hamdan, Hari Krishna Yalamanchili, Kaifang Pang, Amy E. Pohodich, Joanna Lopez, Yingyao Shao, Juan A. Oses-Prieto, Lifang Li, Wonho Kim, Mark A. Durham, Sameer S. Bajikar, Donna J. Palmer, Philip Ng, Michelle L. Thompson, E. Martina Bebin, Amelie J. Müller, Alma Kuechler, Antje Kampmeier, Tobias B. Haack, Alma L. Burlingame, Zhandong Liu, Matthew N. Rasband, Huda Y. Zoghbi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Loss-of-function mutations in MECP2 cause the neurological disorder Rett syndrome (RTT), but the precise molecular mechanism driving pathogenesis remains unclear. Using an unbiased approach to identify proteins that interact with MeCP2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc790c42da5a7a529acd9fb29046340
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85123905308
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85123905308
Autor:
Jacinta Lucero, Joseph R. Ecker, M. Margarita Behrens, Chongyuan Luo, Margaret A. Goodell, Alexander J. Trostle, Kerstin Ure, Joseph R. Nery, Huda Y. Zoghbi, Rosa Castanon, Zhandong Liu, Haijing Jin, Joanna Lopez, Ying-Wooi Wan, Wei Wang, Mark A Durham, Laura A. Lavery
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Methylated cytosine is an effector of epigenetic gene regulation. In the brain, Dnmt3a is the sole ‘writer’ of atypical non-CpG methylation (mCH), and MeCP2 is the only known ‘reader’ for mCH. We asked if MeCP2 is the sole reader for Dnmt3a d
Autor:
Alexander J. Trostle, Joseph R. Ecker, Laura A. Lavery, Wei Wang, Joseph R. Nery, Jacinta Lucero, Rosa Castanon, Zhandong Liu, Haijing Jin, Huda Y. Zoghbi, Chongyuan Luo, Ying-Wooi Wan, Margaret A. Goodell, Joanna Lopez, M. Margarita Behrens, Kerstin Ure, Mark A Durham
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2411cb8fba6e96a9d4fdbabb5277dd
https://doi.org/10.7554/elife.52981.sa2
https://doi.org/10.7554/elife.52981.sa2
Autor:
Jacinta Lucero, Alexander J. Trostle, Laura A. Lavery, Kerstin Ure, Chongyuan Luo, Margaret A. Goodell, Joseph R. Ecker, Mark A Durham, Wei Wang, Joanna Lopez, Joseph R. Nery, Rosa Castanon, Zhandong Liu, Ying-Wooi Wan, Huda Y. Zoghbi, M. Margarita Behrens
Methylated cytosine is an effector of epigenetic gene regulation. In the mammalian brain, the DNA methyltransferase, Dnmt3a, is the sole “writer” of atypical non-CpG methylation (mCH), and methyl CpG binding protein 2 (MeCP2) is the only known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18e9faae4693e5a218c79e8e8114f09
Autor:
Ethan D. Sperry, Elyse N. Reamer, Adam B. Stein, Mark A. Durham, Donna M. Martin, Elizabeth A. Hurd
Publikováno v:
Developmental Dynamics. 243:1055-1066
Background: Heterozygous mutations in the chromatin remodeling gene CHD7 cause CHARGE syndrome, a developmental disorder with variable craniofacial dysmorphisms and respiratory difficulties. The molecular etiologies of these malformations are not wel
Autor:
Ethan D. Sperry, Peter C. Scacheri, Sophia F. Frank, Wanda S. Layman, Jennifer M. Skidmore, Yehoash Raphael, Joseph A. Micucci, Donald L. Swiderski, Donna M. Martin, Mark A. Durham, Elizabeth A. Hurd
Publikováno v:
Human Molecular Genetics. 23:434-448
CHARGE syndrome is a multiple congenital anomaly disorder that leads to life-threatening birth defects, such as choanal atresia and cardiac malformations as well as multiple sensory impairments, that affect hearing, vision, olfaction and balance. CHA