Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Mark A B, Kreutzberger"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Protein filaments are ubiquitous in nature and have diverse biological functions. Cryo-electron microscopy (cryo-EM) enables the determination of atomic structures, even from native samples, and is capable of identifying previously unknown f
Externí odkaz:
https://doaj.org/article/52c4ec16e49348639d7dfd03aa87ed4f
Autor:
Junfeng Liu, Gunnar N. Eastep, Virginija Cvirkaite-Krupovic, Shane T. Rich-New, Mark A. B. Kreutzberger, Edward H. Egelman, Mart Krupovic, Fengbin Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Type IV pili (T4P) represent one of the most common varieties of surface appendages in archaea. These filaments, assembled from small pilin proteins, can be many microns long and serve diverse functions, including adhesion, biofilm formation
Externí odkaz:
https://doaj.org/article/0e35fec9435344379c99ddfd54929828
Autor:
Ravi R. Sonani, Lee K. Palmer, Nathaniel C. Esteves, Abigail A. Horton, Amanda L. Sebastian, Rebecca J. Kelly, Fengbin Wang, Mark A. B. Kreutzberger, William K. Russell, Petr G. Leiman, Birgit E. Scharf, Edward H. Egelman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract A contractile sheath and rigid tube assembly is a widespread apparatus used by bacteriophages, tailocins, and the bacterial type VI secretion system to penetrate cell membranes. In this mechanism, contraction of an external sheath powers the
Externí odkaz:
https://doaj.org/article/8ffa8b55ddc8423ca2316eb1e94a3daa
Autor:
Ravi R. Sonani, Nathaniel C. Esteves, Abigail A. Horton, Rebecca J. Kelly, Amanda L. Sebastian, Fengbin Wang, Mark A. B. Kreutzberger, Petr G. Leiman, Birgit E. Scharf, Edward H. Egelman
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Large gaps exist in our understanding of how bacteriophages, the most abundant biological entities on Earth, assemble and function. The structure of the “neck” region, where the DNA-filled capsid is connected to the host-recognizing tail
Externí odkaz:
https://doaj.org/article/0740d9f71f894ffeb7fdec6eddb67909
Autor:
Leticia C. Beltran, Virginija Cvirkaite-Krupovic, Jessalyn Miller, Fengbin Wang, Mark A. B. Kreutzberger, Jonasz B. Patkowski, Tiago R. D. Costa, Stefan Schouten, Ilya Levental, Vincent P. Conticello, Edward H. Egelman, Mart Krupovic
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Bacteria can exchange DNA through extracellular appendages (‘mating pili’) in a process known as conjugation. Here, Beltran et al. determine atomic structures by cryo-electron microscopy of a bacterial conjugative pilus and two archaeal pili, sho
Externí odkaz:
https://doaj.org/article/44686fdde37848d3a4f975953dcdb8dc
Autor:
Marko Nedeljković, Mark A B Kreutzberger, Sandra Postel, Daniel Bonsor, Yingying Xing, Neil Jacob, William J Schuler, Edward H Egelman, Eric J Sundberg
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1010979 (2023)
In its simplest form, bacterial flagellar filaments are composed of flagellin proteins with just two helical inner domains, which together comprise the filament core. Although this minimal filament is sufficient to provide motility in many flagellate
Externí odkaz:
https://doaj.org/article/d32e90e9c3444d4dabe11ba341ee2037
Autor:
Mark A. B. Kreutzberger, Richard C. Sobe, Amber B. Sauder, Sharanya Chatterjee, Alejandro Peña, Fengbin Wang, Jorge A. Giron, Volker Kiessling, Tiago R. D. Costa, Vincent P. Conticello, Gad Frankel, Melissa M. Kendall, Birgit E. Scharf, Edward H. Egelman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
It has been suggested that the outer domains of bacterial flagellins are not needed for motility. Here, the authors show that flagellar filament outer domains from some bacteria have unique structures which can alter the motility of the bacteria.
Externí odkaz:
https://doaj.org/article/675e18c006ad4e0d88a5c2700432e60a
Autor:
Alex J. B. Kreutzberger, Volker Kiessling, Christopher Stroupe, Binyong Liang, Julia Preobraschenski, Marcelo Ganzella, Mark A. B. Kreutzberger, Robert Nakamoto, Reinhard Jahn, J. David Castle, Lukas K. Tamm
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Regulated exocytosis of neuronal synaptic vesicles is substantially faster than that of endocrine dense core vesicles despite similar molecular machineries. Here authors compare SNARE-mediated fusion of purified synaptic vesicles with insulin vesicle
Externí odkaz:
https://doaj.org/article/4a79a606ae254e35b295a19f8e1dafc2
Autor:
Mark A. B. Kreutzberger, Shengyuan Wang, Leticia C. Beltran, Abraham Tuachi, Xiaobing Zuo, Edward H. Egelman, Vincent P. Conticello
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Phenol-soluble modulins (PSMs) are peptide-based virulence factors that play significant roles in the pathogenesis of staphylococcal strains in community-associated and hospital-associated infections. In addition to cytotoxicity, PSMs display the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426dc1d945078c157616bb82319a945d
https://doi.org/10.1073/pnas.2121586119
https://doi.org/10.1073/pnas.2121586119
Publikováno v:
Proceedings of the National Academy of Sciences. 117:16985-16991
Vertebrates, from zebra fish to humans, have an innate immune recognition of many bacterial flagellins. This involves a conserved eight-amino acid epitope in flagellin recognized by the Toll-like receptor 5 (TLR5). Several important human pathogens,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d383f005cc2322819efb414cfcc109e
https://doi.org/10.1073/pnas.2010996117
https://doi.org/10.1073/pnas.2010996117