Zobrazeno 1 - 10
of 743
pro vyhledávání: '"Mark A Atkinson"'
Autor:
Juan Francisco Morales, Marian Klose, Yannick Hoffert, Jagdeep T. Podichetty, Jackson Burton, Stephan Schmidt, Klaus Romero, Inish O'Doherty, Frank Martin, Martha Campbell‐Thompson, Michael J. Haller, Mark A. Atkinson, Sarah Kim
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1309-1316 (2024)
Abstract Clinical trials seeking to delay or prevent the onset of type 1 diabetes (T1D) face a series of pragmatic challenges. Despite more than 100 years since the discovery of insulin, teplizumab remains the only FDA‐approved therapy to delay pro
Externí odkaz:
https://doaj.org/article/8b4ca31b57414e94973b9675f895a590
Autor:
William R. Lenderking, Yulia Savva, Mark J. Atkinson, Renee Campbell, Isabelle Chabot, Margaret Moline, Genevieve Meier, Charles M. Morin
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 8, Iss 1, Pp 1-12 (2024)
Abstract Background The Insomnia Severity Index (ISI) is a widely used measure of insomnia severity. Various ISI research findings suggest different factor solutions and meaningful within-individual change (MWIC) to detect treatment response in patie
Externí odkaz:
https://doaj.org/article/7f9f97c9d0c94205b47b1870f1dab97e
Autor:
William R. Lenderking, Mark J. Atkinson, Mary Kate Ladd, Yulia Savva, Stephanie Sommer, Matthew Sidovar, Claudia Hastedt
Publikováno v:
Journal of Patient-Reported Outcomes, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract Background Cognitive impairment associated with schizophrenia (CIAS) represents a distinct, persistent, and core group of schizophrenia symptoms. Cognitive symptoms have been shown to have an impact on quality of life. There are several publ
Externí odkaz:
https://doaj.org/article/a2edf1ac7893498dbb640e35f209f41b
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142318 (2015)
The destruction of beta cells in type 1 diabetes (T1D) results in loss of insulin production and glucose homeostasis. Treatment of non-obese diabetic (NOD) mice with immune-depleting/modulating agents (e.g., anti-CD3, murine anti-thymocyte-globulin (
Externí odkaz:
https://doaj.org/article/61af66f598974c93ba39233beef3600d
Autor:
Denise M. Drotar, Ana Karen Mojica-Avila, Drew T. Bloss, Christian M. Cohrs, Cameron T. Manson, Amanda L. Posgai, MacKenzie D. Williams, Maigan A. Brusko, Edward A. Phelps, Clive H. Wasserfall, Stephan Speier, Mark A. Atkinson
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114346- (2024)
Summary: Histopathological heterogeneity in the human pancreas is well documented; however, functional evidence at the tissue level is scarce. Herein, we investigate in situ glucose-stimulated islet and carbachol-stimulated acinar cell secretion acro
Externí odkaz:
https://doaj.org/article/fcfd2fb1042a446182c1c09a0ce0ffd8
Autor:
Al Ozonoff, Naresh Doni Jayavelu, Shanshan Liu, Esther Melamed, Carly E. Milliren, Jingjing Qi, Linda N. Geng, Grace A. McComsey, Charles B. Cairns, Lindsey R. Baden, Joanna Schaenman, Albert C. Shaw, Hady Samaha, Vicki Seyfert-Margolis, Florian Krammer, Lindsey B. Rosen, Hanno Steen, Caitlin Syphurs, Ravi Dandekar, Casey P. Shannon, Rafick P. Sekaly, Lauren I. R. Ehrlich, David B. Corry, Farrah Kheradmand, Mark A. Atkinson, Scott C. Brakenridge, Nelson I. Agudelo Higuita, Jordan P. Metcalf, Catherine L. Hough, William B. Messer, Bali Pulendran, Kari C. Nadeau, Mark M. Davis, Ana Fernandez Sesma, Viviana Simon, Harm van Bakel, Seunghee Kim-Schulze, David A. Hafler, Ofer Levy, Monica Kraft, Chris Bime, Elias K. Haddad, Carolyn S. Calfee, David J. Erle, Charles R. Langelier, Walter Eckalbar, Steven E. Bosinger, IMPACC Network, Bjoern Peters, Steven H. Kleinstein, Elaine F. Reed, Alison D. Augustine, Joann Diray-Arce, Holden T. Maecker, Matthew C. Altman, Ruth R. Montgomery, Patrice M. Becker, Nadine Rouphael
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. M
Externí odkaz:
https://doaj.org/article/ec0ddc29cd90460ca1ec27bea2b831b8
Autor:
Christopher T Brown, Austin G Davis-Richardson, Adriana Giongo, Kelsey A Gano, David B Crabb, Nabanita Mukherjee, George Casella, Jennifer C Drew, Jorma Ilonen, Mikael Knip, Heikki Hyöty, Riitta Veijola, Tuula Simell, Olli Simell, Josef Neu, Clive H Wasserfall, Desmond Schatz, Mark A Atkinson, Eric W Triplett
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25792 (2011)
Recent studies have suggested a bacterial role in the development of autoimmune disorders including type 1 diabetes (T1D). Over 30 billion nucleotide bases of Illumina shotgun metagenomic data were analyzed from stool samples collected from four pair
Externí odkaz:
https://doaj.org/article/e4052e7814af4d9680f764624ed81c2e
Autor:
Todd M Brusko, Richard C Koya, Shirley Zhu, Michael R Lee, Amy L Putnam, Stephanie A McClymont, Michael I Nishimura, Shuhong Han, Lung-Ji Chang, Mark A Atkinson, Antoni Ribas, Jeffrey A Bluestone
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11726 (2010)
Therapies directed at augmenting regulatory T cell (Treg) activities in vivo as a systemic treatment for autoimmune disorders and transplantation may be associated with significant off-target effects, including a generalized immunosuppression that ma
Externí odkaz:
https://doaj.org/article/869e52c785f74606a021f6ec8c540992
Autor:
Ricardo Valladares, Dhyana Sankar, Nan Li, Emily Williams, Kin-Kwan Lai, Asmaa Sayed Abdelgeliel, Claudio F Gonzalez, Clive H Wasserfall, Joseph Larkin, Desmond Schatz, Mark A Atkinson, Eric W Triplett, Josef Neu, Graciela L Lorca
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10507 (2010)
BACKGROUND: The intestinal epithelium is a barrier that composes one of the most immunologically active surfaces of the body due to constant exposure to microorganisms as well as an infinite diversity of food antigens. Disruption of intestinal barrie
Externí odkaz:
https://doaj.org/article/50dd6d3b7bab467798b5c8f5f05eb756
Autor:
Todd M Brusko, Clive H Wasserfall, Maigan A Hulme, Roniel Cabrera, Desmond Schatz, Mark A Atkinson
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7980 (2009)
CD25, a component of the IL-2 receptor, is important in T cell proliferation, activation induced cell death, as well as the actions of both regulatory (Treg) and effector (Teff) T cells. Recent genome wide association studies have implicated the CD25
Externí odkaz:
https://doaj.org/article/ff7867a38ed84fc1b41bac95873e1ec4