Zobrazeno 1 - 10
of 699
pro vyhledávání: '"Mark A, Wainberg"'
Autor:
Eugene L. Asahchop, Oussama Meziane, Manmeet K. Mamik, Wing F. Chan, William G. Branton, Lothar Resch, M. John Gill, Elie Haddad, Jean V. Guimond, Mark A. Wainberg, Glen B. Baker, Eric A. Cohen, Christopher Power
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-17 (2017)
Abstract Background In patients with HIV/AIDS receiving antiretroviral therapy (ART), HIV-1 persistence in brain tissue is a vital and unanswered question. HIV-1 infects and replicates in resident microglia and trafficking macrophages within the brai
Externí odkaz:
https://doaj.org/article/31f0e69c03d54557b35f2606a14b61f7
Autor:
Hong-Tao Xu, Susan P. Colby-Germinario, Said A. Hassounah, Clare Fogarty, Nathan Osman, Navaneethan Palanisamy, Yingshan Han, Maureen Oliveira, Yudong Quan, Mark A. Wainberg
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract We evaluated Sofosbuvir (SOF), the anti-hepatitis C virus prodrug of β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methyluridine-5′-monophosphate, for potential inhibitory activity against DENV replication. Both cell-based and biochemical assay
Externí odkaz:
https://doaj.org/article/0333f7307c094077902d8c0bc4c335fb
Publikováno v:
Retrovirology, Vol 14, Iss 1, Pp 1-16 (2017)
Abstract Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretroviral drugs to be approved for treatment and act by inhibiting the essential HIV protein integrase from inserting the viral DNA genome into the host cell’s chro
Externí odkaz:
https://doaj.org/article/0817f80eba7941e8bbb6799e4039ba51
Publikováno v:
Pathogens and Immunity, Vol 1, Iss 1, Pp 41-67 (2016)
Since the discovery of the first inhibitors of HIV replication, drug resistance has been a major problem in HIV therapy, due, in part, to the high mutation rate of HIV. Therefore, the development of a predictive animal model is important to identify
Externí odkaz:
https://doaj.org/article/b95939978be84d029904bc65de4650ff
Autor:
Zhen Wang, Qinghua Pan, Patrick Gendron, Weijun Zhu, Fei Guo, Shan Cen, Mark A. Wainberg, Chen Liang
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 481-489 (2016)
Cas9 cleaves specific DNA sequences with the assistance of a programmable single guide RNA (sgRNA). Repairing this broken DNA by the cell’s error-prone non-homologous end joining (NHEJ) machinery leads to insertions and deletions (indels) that ofte
Externí odkaz:
https://doaj.org/article/b52e7fc65ba34cbca76fdc4cf62f0f08
Autor:
Thibault Mesplède, Jing Leng, Hanh Thi Pham, Jiaming Liang, Yudong Quan, Yingshan Han, Mark A. Wainberg
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
Externí odkaz:
https://doaj.org/article/eb09fe7f035a4b8a85b39eda5faf86d7
Autor:
Thibault Mesplède, Mark A. Wainberg
Publikováno v:
Viruses, Vol 7, Iss 7, Pp 3703-3718 (2015)
Drug resistance prevents the successful treatment of HIV-positive individuals by decreasing viral sensitivity to a drug or a class of drugs. In addition to transmitted resistant viruses, treatment-naïve individuals can be confronted with the problem
Externí odkaz:
https://doaj.org/article/99530c1aa77e4bf193367a5f570f20fc
Autor:
Mark A. Wainberg, Ying-Shan Han
Publikováno v:
Journal of Virus Eradication, Vol 1, Iss 1, Pp 13-16 (2015)
Integrase strand transfer inhibitors (INSTIs) are the latest class of potent anti-HIV drugs. Currently, three INSTIs have been approved by the US Food and Drug Administration: raltegravir (RAL), elvitegravir (EVG) and dolutegravir (DTG). Resistance m
Externí odkaz:
https://doaj.org/article/f38777e814404a9cac2a4f453dfe5cbb
Publikováno v:
Virologie (Montrouge, France). 15(3)
Wide intra- and inter-subject variability in antiretroviral drug response is observed. Pharmacotherapy of HIV-infected patients is challenging considering the great numbers of co-morbidities increasing the risk of drug-drug interactions. Drug-metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb594f191abb0b8c33f20d0335fb40d4
https://pubmed.ncbi.nlm.nih.gov/36151657
https://pubmed.ncbi.nlm.nih.gov/36151657
Autor:
Thibault Mesplède, Jing Leng, Hanh Thi Pham, Jiaming Liang, Yudong Quan, Yingshan Han, Mark A. Wainberg
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
ABSTRACT Human immunodeficiency virus (HIV) infection persists despite decades of active antiretroviral therapy (ART), effectively preventing viral eradication. Treatment decreases plasma viral RNA, but viral DNA persists, mostly integrated within th
Externí odkaz:
https://doaj.org/article/fe9d8ae16b984049b95ad2d548b322fc