Zobrazeno 1 - 10
of 1 089
pro vyhledávání: '"Mark A, Tarnopolsky"'
Autor:
Lisa A. Pan, Jane C. Naviaux, Lin Wang, Kefeng Li, Jonathan M. Monk, Sai Sachin Lingampelly, Anna Maria Segreti, Kaitlyn Bloom, Jerry Vockley, Mark A. Tarnopolsky, David N. Finegold, David G. Peters, Robert K. Naviaux
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Peripheral blood metabolomics was used to gain chemical insight into the biology of treatment-refractory Major Depressive Disorder with suicidal ideation, and to identify individualized differences for personalized care. The study cohort con
Externí odkaz:
https://doaj.org/article/68ee96b7a9524fae9d5b610c0a3b414f
Autor:
Siddharth Nath, Nicholas S. Caron, Linda May, Oxana B. Gluscencova, Jill Kolesar, Lauren Brady, Brett A. Kaufman, Gabrielle L. Boulianne, Amadeo R. Rodriguez, Mark A. Tarnopolsky, Ray Truant
Publikováno v:
Human Genome Variation, Vol 9, Iss 1, Pp 1-12 (2022)
Neurodegenerative disease: Finding new mutations associated with ataxia Two genetic mutations combine to cause a novel variant of spinocerebellar ataxia (SCA), a rare neurodegenerative disease. SCA affects the cerebellum, a brain region that controls
Externí odkaz:
https://doaj.org/article/3daafa26d2c04bf0a4a4c5ae75472e88
Autor:
Hong Joo Kim, Payam Mohassel, Sandra Donkervoort, Lin Guo, Kevin O’Donovan, Maura Coughlin, Xaviere Lornage, Nicola Foulds, Simon R. Hammans, A. Reghan Foley, Charlotte M. Fare, Alice F. Ford, Masashi Ogasawara, Aki Sato, Aritoshi Iida, Pinki Munot, Gautam Ambegaonkar, Rahul Phadke, Dominic G. O’Donovan, Rebecca Buchert, Mona Grimmel, Ana Töpf, Irina T. Zaharieva, Lauren Brady, Ying Hu, Thomas E. Lloyd, Andrea Klein, Maja Steinlin, Alice Kuster, Sandra Mercier, Pascale Marcorelles, Yann Péréon, Emmanuelle Fleurence, Adnan Manzur, Sarah Ennis, Rosanna Upstill-Goddard, Luca Bello, Cinzia Bertolin, Elena Pegoraro, Leonardo Salviati, Courtney E. French, Andriy Shatillo, F. Lucy Raymond, Tobias B. Haack, Susana Quijano-Roy, Johann Böhm, Isabelle Nelson, Tanya Stojkovic, Teresinha Evangelista, Volker Straub, Norma B. Romero, Jocelyn Laporte, Francesco Muntoni, Ichizo Nishino, Mark A. Tarnopolsky, James Shorter, Carsten G. Bönnemann, J. Paul Taylor
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Missense variants in RNA-binding proteins underlie many diseases. Here the authors report an oculopharyngeal muscular dystrophy caused by heterozygous frameshift mutations in HNRNPA2B1 that alter its nucleocytoplasmic transport dynamics and result in
Externí odkaz:
https://doaj.org/article/43f9513e8b2941959cf7d7957b2785b1
Autor:
Paul F. Lebeau, Jae Hyun Byun, Khrystyna Platko, Paul Saliba, Matthew Sguazzin, Melissa E. MacDonald, Guillaume Paré, Gregory R. Steinberg, Luke J. Janssen, Suleiman A. Igdoura, Mark A. Tarnopolsky, S. R. Wayne Chen, Nabil G. Seidah, Jakob Magolan, Richard C. Austin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Caffeine may reduce cardiovascular disease risk, but the underlying mechanisms for these effects are incompletely understood. Here the authors report that caffeine inhibits the activation of the transcription factor SREBP2 to promote LDLc clearance t
Externí odkaz:
https://doaj.org/article/6733f73670aa4d5a807867eed2c293ea
Autor:
Monika Oláhová, Bradley Peter, Zsolt Szilagyi, Hector Diaz-Maldonado, Meenakshi Singh, Ewen W. Sommerville, Emma L. Blakely, Jack J. Collier, Emily Hoberg, Viktor Stránecký, Hana Hartmannová, Anthony J. Bleyer, Kim L. McBride, Sasigarn A. Bowden, Zuzana Korandová, Alena Pecinová, Hans-Hilger Ropers, Kimia Kahrizi, Hossein Najmabadi, Mark A. Tarnopolsky, Lauren I. Brady, K. Nicole Weaver, Carlos E. Prada, Katrin Õunap, Monica H. Wojcik, Sander Pajusalu, Safoora B. Syeda, Lynn Pais, Elicia A. Estrella, Christine C. Bruels, Louis M. Kunkel, Peter B. Kang, Penelope E. Bonnen, Tomáš Mráček, Stanislav Kmoch, Gráinne S. Gorman, Maria Falkenberg, Claes M. Gustafsson, Robert W. Taylor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
POLRMT is key for transcription of the mitochondrial genome, yet has not been implicated in mitochondrial disease to date. Here, the authors identify mutations in POLRMT in individuals with mitochondrial disease-related phenotypes and characterise un
Externí odkaz:
https://doaj.org/article/35895711cd76476484b7067a5177046a
Autor:
Andrew I. Mikhail, Peter L. Nagy, Katherine Manta, Nicholas Rouse, Alexander Manta, Sean Y. Ng, Michael F. Nagy, Paul Smith, Jian-Qiang Lu, Joshua P. Nederveen, Vladimir Ljubicic, Mark A. Tarnopolsky
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Background Myotonic dystrophy type 1 (DM1) is a complex life-limiting neuromuscular disorder characterized by severe skeletal muscle atrophy, weakness, and cardiorespiratory defects. Exercised DM1 mice exhibit numerous physiological benefits that are
Externí odkaz:
https://doaj.org/article/d04ddf128d514ac6bf0bcdd3b57cec27
Autor:
Fernando F. Anhê, Soumaya Zlitni, Nicole G. Barra, Kevin P. Foley, Mats I. Nilsson, Joshua P. Nederveen, Lauren G. Koch, Steven L. Britton, Mark A. Tarnopolsky, Jonathan D. Schertzer
Publikováno v:
Physiological Reports, Vol 10, Iss 5, Pp n/a-n/a (2022)
Abstract High aerobic endurance capacity can be acquired by training and/or inherited. Aerobic exercise training (AET) and aging are linked to altered gut microbiome composition, but it is unknown if the environmental stress of exercise and host gene
Externí odkaz:
https://doaj.org/article/d6b7b4c6e9f640569de57fe79f1af509
Autor:
Joshua P. Nederveen, Geoffrey Warnier, Alessia Di Carlo, Mats I. Nilsson, Mark A. Tarnopolsky
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
The benefits of exercise on health and longevity are well-established, and evidence suggests that these effects are partially driven by a spectrum of bioactive molecules released into circulation during exercise (e.g., exercise factors or ‘exerkine
Externí odkaz:
https://doaj.org/article/fc99cf386959424c80b96054f0edbdfe
Publikováno v:
Cosmetics, Vol 9, Iss 3, p 47 (2022)
The macroscopic and microscopic deterioration of human skin with age is, in part, attributed to a functional decline in mitochondrial health. We previously demonstrated that exercise attenuated age-associated changes within the skin through enhanced
Externí odkaz:
https://doaj.org/article/0e6236b502d141c08c91a7476579e5fe
Autor:
Lauren E. Skelly, Martin J. MacInnis, William Bostad, Devin G. McCarthy, Elizabeth M. Jenkins, Linda R. Archila, Mark A. Tarnopolsky, Martin J. Gibala
Publikováno v:
Scandinavian Journal of Medicine & Science in Sports. 33:872-881
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf89298423bec7f8ea570651cc57e81
https://doi.org/10.1111/sms.14332
https://doi.org/10.1111/sms.14332