Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Mark A, Herzik"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
The application of machine learning to cryogenic electron microscopy (cryoEM) data analysis has added a valuable set of tools to the cryoEM data processing pipeline. As these tools become more accessible and widely available, the implications of thei
Externí odkaz:
https://doaj.org/article/023944c32f744eef934ce3d2dc1f4d59
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Despite many recent advances in cryo-EM, imaging smaller macromolecules (below 100 kDa) has remained a challenge. Here the authors show that biological specimens amassing
Externí odkaz:
https://doaj.org/article/082a304c2b0a4f3b94de0ccbd7867848
Autor:
Lejla Zubcevic, Mark A. Herzik, Mengyu Wu, William F. Borschel, Marscha Hirschi, Albert S. Song, Gabriel C. Lander, Seok-Yong Lee
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Transient receptor potential vanilloid channel 3 (TRPV3) responds to temperature and sensitizes upon repeated stimulation with either heat or agonists. Here authors present the cryo-EM structures of apo and sensitized human TRPV3 and describe the str
Externí odkaz:
https://doaj.org/article/2ea7563e099f422d909405e9c45dad14
Publikováno v:
Journal of Structural Biology: X, Vol 4, Iss , Pp 100020- (2020)
Although the advent of direct electron detectors (DEDs) and software developments have enabled the routine use of single-particle cryogenic electron microscopy (cryo-EM) for structure determination of well-behaved specimens to high-resolution, there
Externí odkaz:
https://doaj.org/article/3770620418bf4cebab35038e831371fe
Autor:
Kondababu Kurakula, Duco S. Koenis, Mark A. Herzik, Yanyun Liu, John W. Craft, Pieter B. van Loenen, Mariska Vos, M. Khang Tran, Henri H. Versteeg, Marie-José T.H. Goumans, Wolfram Ruf, Carlie J.M. de Vries, Mehmet Şen
Publikováno v:
Haematologica, Vol 103, Iss 6 (2018)
Tissue Factor is a cell-surface glycoprotein expressed in various cells of the vasculature and is the principal regulator of the blood coagulation cascade and hemostasis. Notably, aberrant expression of Tissue Factor is associated with cardiovascular
Externí odkaz:
https://doaj.org/article/f24af6fdbd004558a55a651fb28171cf
Publikováno v:
Science
Science (New York, N.Y.), vol 377, iss 6608
Science (New York, N.Y.), vol 377, iss 6608
The enzyme nitrogenase couples adenosine triphosphate (ATP) hydrolysis to the multielectron reduction of atmospheric dinitrogen into ammonia. Despite extensive research, the mechanistic details of ATP-dependent energy transduction and dinitrogen redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effcc9a889bdac1052a0c6f13460884a
https://europepmc.org/articles/PMC9949965/
https://europepmc.org/articles/PMC9949965/
The enzyme nitrogenase couples adenosine triphosphate (ATP) hydrolysis to the multi-electron reduction of atmospheric dinitrogen into ammonia. Despite extensive research, the mechanistic details of ATP-dependent energy transduction and dinitrogen red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b152fec398b5c0798e95d7731590636
https://doi.org/10.1101/2022.06.05.494884
https://doi.org/10.1101/2022.06.05.494884
Autor:
Kevin D, Corbett, Mark A, Herzik
Publikováno v:
Nature methods. 19(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62ac45c39d14563443df137e25d09cc8
https://pubmed.ncbi.nlm.nih.gov/35637302
https://pubmed.ncbi.nlm.nih.gov/35637302
Publikováno v:
Journal of visualized experiments : JoVE. (180)
Imaging biological specimens with electrons for high-resolution structure determination by single-particle cryogenic electron microscopy (cryoEM) requires a thin layer of vitreous ice containing the biomolecules of interest. Despite numerous technolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418acac96c3c0a0dc97a276462633f62
https://pubmed.ncbi.nlm.nih.gov/35188117
https://pubmed.ncbi.nlm.nih.gov/35188117
Publikováno v:
eLife, Vol 5 (2016)
The 26S proteasome is responsible for the selective, ATP-dependent degradation of polyubiquitinated cellular proteins. Removal of ubiquitin chains from targeted substrates at the proteasome is a prerequisite for substrate processing and is accomplish
Externí odkaz:
https://doaj.org/article/2c180e2fda1940f5a4029f205300f727