Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Mark A, Coles"'
Autor:
Jolet Y. Mimpen, Robert Hedley, Anna Ridley, Mathew J. Baldwin, Dylan Windell, Ananya Bhalla, Lorenzo Ramos-Mucci, Christopher D. Buckley, Mark C. Coles, Abtin Alvand, Andrew J. Price, Andrew J. Carr, Stephanie G. Dakin, Sarah J. B. Snelling
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-15 (2023)
Abstract Objectives Osteoarthritis (OA) is increasingly recognised as a whole joint disease, with an important role for synovium. However, the repertoire of immune cells and fibroblasts that constitute OA synovium remains understudied. This study aim
Externí odkaz:
https://doaj.org/article/ad4812c86da64d16ae2f61590a6143f6
Autor:
Aleksandra E. Kmieciak, Liam V. Brown, Mark C. Coles, Jonathan Wagg, Alex Phipps, Eamonn A. Gaffney
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The spleen, a secondary lymphoid tissue (SLT), has an important role in generation of adaptive immune responses. Although splenectomy remains a common procedure, recent studies reported poor prognosis and increased risk of haematological mal
Externí odkaz:
https://doaj.org/article/fe7cfd469db94e7c966dffd618e7752f
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010112 (2022)
Cell-cell communication is mediated by many soluble mediators, including over 40 cytokines. Cytokines, e.g. TNF, IL1β, IL5, IL6, IL12 and IL23, represent important therapeutic targets in immune-mediated inflammatory diseases (IMIDs), such as inflamm
Externí odkaz:
https://doaj.org/article/f2398cb73db84a9b8000a43ff7df9830
Autor:
Jason Cosgrove, Mario Novkovic, Stefan Albrecht, Natalia B. Pikor, Zhaoukun Zhou, Lucas Onder, Urs Mörbe, Jovana Cupovic, Helen Miller, Kieran Alden, Anne Thuery, Peter O’Toole, Rita Pinter, Simon Jarrett, Emily Taylor, Daniel Venetz, Manfred Heller, Mariagrazia Uguccioni, Daniel F. Legler, Charles J. Lacey, Andrew Coatesworth, Wojciech G. Polak, Tom Cupedo, Bénedicte Manoury, Marcus Thelen, Jens V. Stein, Marlene Wolf, Mark C. Leake, Jon Timmis, Burkhard Ludewig, Mark C. Coles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes
Externí odkaz:
https://doaj.org/article/a29fe9ea7a8d465093c19a3301a148f3
Autor:
Ian R. Reekie, Srilakshmi Sharma, Andrew Foers, Jonathan Sherlock, Mark C. Coles, Andrew D. Dick, Alastair K. Denniston, Christopher D. Buckley
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
The uveal tract consists of the iris, the ciliary body and the choroid; these three distinct tissues form a continuous layer within the eye. Uveitis refers to inflammation of any region of the uveal tract. Despite being grouped together anatomically,
Externí odkaz:
https://doaj.org/article/bf825a18d9a14d9e81bbab26e78ed53e
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
To effectively navigate complex tissue microenvironments, immune cells sense molecular concentration gradients using G-protein coupled receptors. However, due to the complexity of receptor activity, and the multimodal nature of chemokine gradients in
Externí odkaz:
https://doaj.org/article/6eb0626067c14dae95482605da0c95c2
Autor:
Russell Foxall, Priyanka Narang, Bridget Glaysher, Elin Hub, Emma Teal, Mark C. Coles, Margaret Ashton-Key, Stephen A. Beers, Mark S. Cragg
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Diffuse large cell B cell lymphoma (DLBCL) accounts for approximately 30%–40% of all non-Hodgkin lymphoma (NHL) cases. Current first line DLBCL treatment results in long-term remission in more than 60% of cases. However, those patients with primary
Externí odkaz:
https://doaj.org/article/f7e066eab461442e986826c1d67e4590
Autor:
Paul R. Buckley, Kieran Alden, Margherita Coccia, Aurélie Chalon, Catherine Collignon, Stéphane T. Temmerman, Arnaud M. Didierlaurent, Robbert van der Most, Jon Timmis, Claus A. Andersen, Mark C. Coles
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Novel adjuvant technologies have a key role in the development of next-generation vaccines, due to their capacity to modulate the duration, strength and quality of the immune response. The AS01 adjuvant is used in the malaria vaccine RTS,S/AS01 and i
Externí odkaz:
https://doaj.org/article/5a240aa006c54bf8a92b460c8d920e74
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
This perspective outlines an approach to improve mechanistic understanding of macrophages in inflammation and tissue homeostasis, with a focus on human inflammatory bowel disease (IBD). The approach integrates wet-lab and in-silico experimentation, d
Externí odkaz:
https://doaj.org/article/ccea25cf36374e4fa84116e061930c20
Autor:
Zhi Li, Tom Hodgkinson, Elizabeth J. Gothard, Soulmaz Boroumand, Rebecca Lamb, Ian Cummins, Priyanka Narang, Amy Sawtell, Jenny Coles, German Leonov, Andrea Reboldi, Christopher D. Buckley, Tom Cupedo, Christian Siebel, Ardeshir Bayat, Mark C. Coles, Carrie A. Ambler
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
In normal skin, Notch directs keratinocytes to terminally differentiate. Here the authors show that Notch1 has a wider role in skin repair; Notch1 is activated in keratinocytes after damage and drives transcription of TNFα and inflammatory chemokine
Externí odkaz:
https://doaj.org/article/843bd1d443c040959d4e14ce28f79819