Zobrazeno 1 - 10
of 351
pro vyhledávání: '"Mark A, Burns"'
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract Traumatic brain injury (TBI) is a major cause of disability and mortality worldwide, particularly among the elderly, yet our mechanistic understanding of what renders the post-traumatic brain vulnerable to poor outcomes, and susceptible to n
Externí odkaz:
https://doaj.org/article/3e9d9f0ab5f045a19da8039dbeae845f
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Traumatic Brain Injury (TBI) is a major cause of disability and mortality, particularly among the elderly, yet our mechanistic understanding of how age renders the post-traumatic brain vulnerable to poor clinical outcomes and susceptible to neurologi
Externí odkaz:
https://doaj.org/article/875e4381949e4e71a11cc295bd5c474b
Publikováno v:
PLoS ONE, Vol 18, Iss 7, p e0288363 (2023)
The pathophysiological changes that occur after traumatic brain injury (TBI) can lead to the development of post-traumatic epilepsy, a life-long complication of brain trauma. The etiology of post-traumatic epilepsy remains unknown, but TBI brains exh
Externí odkaz:
https://doaj.org/article/2babeeac2c6c442d8292e7729c372ad7
Autor:
Stephanie S. Sloley, Bevan S. Main, Charisse N. Winston, Alex C. Harvey, Alice Kaganovich, Holly T. Korthas, Adam P. Caccavano, David N. Zapple, Jian-young Wu, John G. Partridge, Mark R. Cookson, Stefano Vicini, Mark P. Burns
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Repeated head impact exposure can cause memory and behavioural impairments but the physiological changes in the brain are not well understood. Here, the authors reveal synaptic adaptations as a potential mechanism for early abnormal behavioural event
Externí odkaz:
https://doaj.org/article/8e3cddd729eb493188315a1ff611d883
Autor:
Aaminah Khan, Laura D. Gamble, Dannielle H. Upton, Caitlin Ung, Denise M. T. Yu, Anahid Ehteda, Ruby Pandher, Chelsea Mayoh, Steven Hébert, Nada Jabado, Claudia L. Kleinman, Mark R. Burns, Murray D. Norris, Michelle Haber, Maria Tsoli, David S. Ziegler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Diffuse intrinsic pontine glioma (DIPG) is an almost incurable malignant childhood brain tumor. Here, the authors show that the polyamine synthetic pathway is activated in DIPG and that the dual targeting of polyamine synthesis and uptake results in
Externí odkaz:
https://doaj.org/article/4116e5b63fd745dd8d4fa955d44571c8
Publikováno v:
Biosensors, Vol 13, Iss 3, p 331 (2023)
Urinary chloride concentration is a valuable health metric that can aid in the early detection of serious conditions, such as acid base disorders, acute heart failure, and incidences of acute renal failure in the intensive care unit. Physiologically,
Externí odkaz:
https://doaj.org/article/cff91ecde472464fb8236010902ca572
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2022)
We have recently shown that the cognitive impairments in a mouse model of high-frequency head impact (HFHI) are caused by chronic changes to synaptic physiology. To better understand these synaptic changes occurring after repeat head impact, we used
Externí odkaz:
https://doaj.org/article/ce02e6ac21404e2dacff27ad772ed698
Publikováno v:
Methods and Protocols, Vol 5, Iss 5, p 77 (2022)
In aging, the brain is more vulnerable to injury and neurodegenerative disease, but the mechanisms responsible are largely unknown. Evidence now suggests that neuroinflammation, mediated by resident brain astrocyte and microglia populations, are key
Externí odkaz:
https://doaj.org/article/1e1a5654de6541c098cc9c2d31a30903
Autor:
Holly T. Korthas, Bevan S. Main, Alex C. Harvey, Ruchelle G. Buenaventura, Evan Wicker, Patrick A. Forcelli, Mark P. Burns
Publikováno v:
Biology, Vol 11, Iss 7, p 1031 (2022)
Traumatic brain injury (TBI) is a significant risk factor for the development of sleep and circadian rhythm impairments. In this study we compare the circadian rhythms and sleep patterns in the high-frequency head impact (HFHI) and controlled cortica
Externí odkaz:
https://doaj.org/article/987c63714e934e91b974e82c26918d11
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Glucose is an essential cellular fuel for maintaining normal brain functions. Traumatic brain injury (TBI) decreases brain glucose utilization in both human and experimental animals during the acute or subacute phase of TBI. It remains unclear as to
Externí odkaz:
https://doaj.org/article/1936c6b5dd284e0bbd9c5e60741bf9d5