Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mark Purdie"'
Autor:
Adam D. Clayton, Edward O. Pyzer‐Knapp, Mark Purdie, Martin F. Jones, Alexandre Barthelme, John Pavey, Nikil Kapur, Thomas W. Chamberlain, A. John Blacker, Richard A. Bourne
Publikováno v:
Angewandte Chemie. 135
The optimization of multistep chemical syntheses is critical for the rapid development of new pharmaceuticals. However, concatenating individually optimized reactions can lead to inefficient multistep syntheses, owing to chemical interdependencies be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b8a041ca8950a4920f97a0283b45d5
https://doi.org/10.1002/ange.202214511
https://doi.org/10.1002/ange.202214511
Publikováno v:
Journal of Molecular Catalysis A: Chemical. 324:39-47
DFT calculations have been used to explore the full catalytic cycle of the Suzuki–Miyaura coupling between PhBr and PhB(OH)3− with four different palladium monophosphine catalysts derived from Pd(PMe3)2, Pd(P(CF3)3)2, Pd(PPh3)2 and Pd(PtBu3)2. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5b9e668a1440097d24510356033cfb8
https://doi.org/10.1016/j.molcata.2010.02.021
https://doi.org/10.1016/j.molcata.2010.02.021
Autor:
Nicholas Greeves, Steven P McLachlan, Mark Purdie, Graham H Oakes, Jamie F. Bickley, Wai-Man Lee
Publikováno v:
Tetrahedron Letters. 44:9035-9038
A stereoselective potassium hydride/18-crown-6 mediated double tandem etherification-[2,3]-Wittig-anionic oxy-Cope rearrangement was used to prepare a δ,e-unsaturated aldehyde with syn stereochemistry. Wittig olefination, dihydroxylation and stereos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9a10d826b3105ef46941620901c9b17
https://doi.org/10.1016/j.tetlet.2003.09.209
https://doi.org/10.1016/j.tetlet.2003.09.209
Autor:
Jeremy N. Harvey, Gareth J. J. Owen-Smith, Mark Purdie, David R. J. Hose, Paul M. Murray, A. Guy Orpen, Natalie Fey, Guy C. Lloyd-Jones, Louise A. Evans, Robert Osborne
Publikováno v:
Journal of the American Chemical Society. 130:14471-14473
The kinetics of Pd-catalyzed Tsuji-Trost allylation employing simple phosphine ligands (L = Ar3P, etc.) are consistent with turnover-limiting nucleophilic attack of an electrophilic [L2Pd(allyl)]+ catalytic intermediate. Counter-intuitively, when L i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1435b4fd8f47ca2a77ab06326abcd455
https://doi.org/10.1021/ja806278e
https://doi.org/10.1021/ja806278e
Publikováno v:
Journal of the American Chemical Society. 120:2553-2562
A total synthesis of natural levorotatory spinosyn A (1) has been achieved. The first objective, to confirm the absolute configurational assignment of tricyclic ketone 2 prepared earlier, was accomplished by oxidative degradation of the macrocyclic l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4acf0edcae48df19bfdafbe81a4e57a1
https://doi.org/10.1021/ja974010k
https://doi.org/10.1021/ja974010k
Publikováno v:
Tetrahedron Letters. 37:8929-8932
The 2-(R)and 2-(S)-hydroxy-1-phenylbutan-1-ones have been prepared in high enantiomeric excesses and in five steps from propanal using a dithiane oxide unit as an asymmetric building block and a modified Sharpless enantioselective sulphur oxidation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0040a56f6f5c209ad3c8da53255258b
https://doi.org/10.1016/s0040-4039(96)02050-3
https://doi.org/10.1016/s0040-4039(96)02050-3
Publikováno v:
ChemInform. 43
The arylation step favors aryl bromides bearing electron-withdrawing substituents, while the acylation reaction is supported by electron-donating groups.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2260234596e0f0848c357851cec8ef11
https://doi.org/10.1002/chin.201207074
https://doi.org/10.1002/chin.201207074
Publikováno v:
Organic letters. 13(20)
A one-pot, two-step catalytic protocol has been developed. A regioselective Heck coupling between aryl bromides and allyl alcohol leads to the generation of arylated allyl alcohols that in situ isomerize to give aldehydes, which then undergo an acyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bf4ccbd579c2837a9403ef5f4a91c0
https://pubmed.ncbi.nlm.nih.gov/21932768
https://pubmed.ncbi.nlm.nih.gov/21932768
Publikováno v:
ChemInform. 41
A number of aryl chlorides undergoes direct acylation with various aldehydes under the optimized conditions shown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0253bc5efcee880bff0c9c3fb01a828c
https://doi.org/10.1002/chin.201051073
https://doi.org/10.1002/chin.201051073
Publikováno v:
Organic letters. 12(16)
A palladium catalyst system has been developed that allows for the direct acylation of aryl chlorides with aldehydes. The choice of ligand, as well as the presence of pyrrolidine and molecular sieves is shown to be critical to the catalysis, which ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ec45e4406ea17eb411921584f49ae2
https://pubmed.ncbi.nlm.nih.gov/20704412
https://pubmed.ncbi.nlm.nih.gov/20704412