Výsledky vyhledávání - "Mark Liddell"

Using transcriptomics, proteomics and phosphoproteomics as new approach methodology (NAM) to define biological responses for chemical safety assessment

Publikováno v: Chemosphere. 313

Omic-based technologies are of particular interest and importance for hazard identification and health risk characterization of chemicals. Their application in the new approach methodologies (NAMs) anchored on cellular toxicity pathways is based on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c291963dbdf9ab1345228840004078
https://pubmed.ncbi.nlm.nih.gov/36427571

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Using NAMs to characterize chemical bioactivity at the transcriptomic, proteomic and phosphoproteomic levels

Omic-based technologies are of particular interest and importance for non-animal chemical hazard and risk characterization based on the premise that any apical endpoint change must be underpinned by some alterations measured at the omic levels. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d58a2cb92a56413a5f4b46106e3c72e2
https://doi.org/10.1101/2022.05.18.492410

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Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells

Autor: Zhenpeng Zhang, Yao Zhang, Yuan Li, Songhao Jiang, Feng Xu, Kaixuan Li, Lei Chang, Huiying Gao, Predrag Kukic, Paul Lawford Carmichael, Mark Liddell, Jin Li, Qiang Zhang, Zhitang Lyu, Shuangqing Peng, Tao Zuo, Liz Tulum, Ping Xu

Publikováno v: Toxicology and applied pharmacology. 449

Protein phosphorylation is the most common type of post-translational modification where serine, threonine or tyrosine are reversibly bound to the phosphate group of ATP in a reaction catalyzed by protein kinases. Phosphorylation plays an important r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca1bff235c6ab85eb56593778c9df43
https://pubmed.ncbi.nlm.nih.gov/35688186

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The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration

Autor: Peiru Chen, Yuan Li, Feng Xu, Zhenpeng Zhang, Tao Zuo, Jiabin Guo, Kaixuan Li, Shu Liu, Suzhen Li, Jian Yin, Lei Chang, Predrag Kukic, Mark Liddell, Liz Tulum, Paul Carmichael, Shuangqing Peng, Jin Li, Qiang Zhang, Ping Xu

Next-generation risk assessment for environmental chemicals and ingredients in consumer products involves a weight of evidence (WoE) framework integrating a suite of new approach methodologies (NAMs) based on points of departure (PoD) obtained fromin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55c39f567dfdba30cd00343e56c55811
https://doi.org/10.1101/2022.04.07.487458

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Latent Variables Capture Pathway-Level Points of Departure in High-Throughput Toxicogenomic Data

Autor: Danilo Basili, Joe Reynolds, Jade Houghton, Sophie Malcomber, Bryant Chambers, Mark Liddell, Iris Muller, Andrew White, Imran Shah, Logan J. Everett, Alistair Middleton, Andreas Bender

Publikováno v: Chemical research in toxicology. 35(4)

Funder: Unilever
Estimation of points of departure (PoDs) from high-throughput transcriptomic data (HTTr) represents a key step in the development of next-generation risk assessment (NGRA). Current approaches mainly rely on single key gene targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f6503ca7fd2dc4da04fae8597ad714
https://pubmed.ncbi.nlm.nih.gov/35333521

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