Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Mark Herb"'
Autor:
Michael E. Milewski, Bruce E. Maryanoff, H. Steve White, Mary Lou Lubin, Mark Herb, Michael F. A. Finley, Douglas E. Brenneman, Allen B. Reitz, Ewa Malatynska, Ning Qin, Karen S. Wilcox, Smith-Swintosky Virginia L, Yi Liu, Parker Michael H, Brian D. Klein, Mccomsey David F
Broad-spectrum anticonvulsants are of considerable interest as antiepileptic drugs, especially because of their potential for treating refractory patients. Such "neurostabilizers" have also been used to treat other neurological disorders, including m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8217beecc01fd20cf1673325073c638
https://europepmc.org/articles/PMC4004761/
https://europepmc.org/articles/PMC4004761/
Autor:
Laurent Leclercq, Brian D. Klein, Robert Iannucci, Michael H. Parker, Ning Qin, Yifang Huang, Smith-Swintosky Virginia L, David F. McComsey, Michael F.A. Finley, Ewa Malatynska, Allen B. Reitz, Michael E. Milewski, Mary Lou Lubin, Bruce E. Maryanoff, H. Steve White, Mark Herb, Filip Cuyckens, Yi Liu, Douglas E. Brenneman
Publikováno v:
Journal of medicinal chemistry. 52(23)
In seeking broad-spectrum anticonvulsants to treat epilepsy and other neurological disorders, we synthesized and tested a group of sulfamide derivatives (4a-k, 5), which led to the clinical development of 4a (JNJ-26990990). This compound exhibited ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23965975217c54526da2173fe275e9c
https://pubmed.ncbi.nlm.nih.gov/19388676
https://pubmed.ncbi.nlm.nih.gov/19388676
Autor:
Ceusters Marc Andre, Marcel Gerebernus Maria Luyckx, Wouters Walter Boudewijn Leopo, Raymond Antoine Stokbroekx, Marcel Jozef Maria Van Der Aa, Mark Herb, Gerda Smets, Jean-Pierre Bongartz, Lieven Meerpoel, Charlie Bowden, Lisa Valletta, Rose Tominovich, Tuman Robert W, Marc Willems, Tine Jansen
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(4)
General screening for inhibitors of microvessel growth in vitro in the rat aortic ring assay led to the discovery of a novel series of thiadiazole pyridazine compounds with potential anti-angiogenic activity. Chemical optimization produced orally act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a339ae563fd1d8549c036d23eb9cb3b0
https://pubmed.ncbi.nlm.nih.gov/11844678
https://pubmed.ncbi.nlm.nih.gov/11844678
Autor:
Tine Jansen, Gerda Smets, Lisa Valletta, Wouters Walter Boudewijn Leopo, Rose Tominovich, Charlie Bowden, Jean-Pierre Bongartz, Marcel Gerebernus Maria Luyckx, Ceusters Marc Andre, Raymond Antoine Stokbroekx, Marcel Jozef Maria Van Der Aa, Marc Willems, Tuman Robert W, Lieven Meerpoel, Mark Herb
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1133-1134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fdb984bfea5e78feff1cb3fcf59b7d8
https://doi.org/10.1016/s0960-894x(02)00116-6
https://doi.org/10.1016/s0960-894x(02)00116-6
Autor:
Michael H. Parker, Virginia L. Smith-Swintosky, David F. McComsey, Yifang Huang, Douglas Brenneman, Brian Klein, Ewa Malatynska, H. Steve White, Michael E. Milewski, Mark Herb, Michael F. A. Finley, Yi Liu, Mary Lou Lubin, Ning Qin, Robert Iannucci, Laurent Leclercq, Filip Cuyckens, Allen B. Reitz, Bruce E. Maryanoff
Publikováno v:
Journal of Medicinal Chemistry; Dec2009, Vol. 52 Issue 23, p7528-7536, 9p