Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mark Federici"'
Autor:
Victoria A. Engel, Yangshin Park, Neo C. Hoang, Li Wan, Ruslan Sanishvili, Mu Wang, Alexandra Beilina, Mark R. Cookson, Jingling Liao, Misook Oh, Chun-Xiang Wu, Xylena Reed, Yuichiro Takagi, Steven M. Johnson, Mark Federici, Quyen Q. Hoang, R. Jeremy Nichols
Leucine-rich repeat kinase 2 (LRRK2) is a large 286 kDa multi-domain protein whose mutation is a common cause of Parkinson’s disease (PD). One of the common sites of familial PD-associated mutations occurs at residue Arg-1441 in the GTPase domain o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20427395ab0d2d9d90f7388d1038b9f9
Autor:
Yangshin Park, Xylena Reed, Mark Federici, Yuichiro Takagi, Ruslan Sanishvili, Mu Wang, Quyen Q. Hoang, Jingling Liao, R. Jeremy Nichols, Neo C. Hoang, Mark R. Cookson, Steven M. Johnson, Chun-Xiang Wu, Victoria A. Engel
Publikováno v:
The Journal of biological chemistry. 294(15)
Mutation in leucine-rich repeat kinase 2 (LRRK2) is a common cause of familial Parkinson's disease (PD). Recently, we showed that a disease-associated mutation R1441H rendered the GTPase domain of LRRK2 catalytically less active and thereby trapping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb3e96a808232699e93bb6cd87d6ac1
https://pubmed.ncbi.nlm.nih.gov/30796162
https://pubmed.ncbi.nlm.nih.gov/30796162
Autor:
Heather Sahm, Zhong Yin Zhang, Todd A. Stone, Sheng Zhang, Kurt W. Vogel, Mu Wang, Dali Liu, Mark R. Cookson, Jingling Liao, Christopher Burlak, Quyen Q. Hoang, R. Jeremy Nichols, Mark Federici, Chun Xiang Wu, Steve Riddle
Publikováno v:
Proceedings of the National Academy of Sciences. 111:4055-4060
Mutation in leucine-rich-repeat kinase 2 (LRRK2) is a common cause of Parkinson disease (PD). A disease-causing point mutation R1441H/G/C in the GTPase domain of LRRK2 leads to overactivation of its kinase domain. However, the mechanism by which this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9656b51240703e2457e787d01c943f
https://doi.org/10.1073/pnas.1323285111
https://doi.org/10.1073/pnas.1323285111
Autor:
Stephen C. Rubin, Marie Plante, Connie L. Finstad, G B S Mark Federici, Guenther A. Gastl, George Y. Wong
Publikováno v:
Cancer. 73:1882-1888
Background. Interleukin-6 (IL-6) is a multifunctional cytokine that can be produced by human ovarian cancer cells. Elevated IL-6 levels have been found in the serum and ascites of patients with ovarian cancer, but its role in this disease has not bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::028fe9618da394440acfd2a5d232ed15
https://doi.org/10.1002/1097-0142(19940401)73:7<1882::aid-cncr2820730718>3.0.co
https://doi.org/10.1002/1097-0142(19940401)73:7<1882::aid-cncr2820730718>3.0.co
Autor:
G B S Mark Federici, Connie L. Finstad, William J. Hoskins, B S Linda Scheiner, Stephen C. Rubin, Kenneth O. Lloyd
Publikováno v:
Cancer. 73:1456-1459
Background. Although expression of the HER-2/neu oncogene may be of some prognostic importance in advanced ovarian cancer, its role in early-stage disease has not been established. The current study examined the prevalence and significance of HER-2/n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b522199aaeb3e98359287aa5a9084c78
https://doi.org/10.1002/1097-0142(19940301)73:5<1456::aid-cncr2820730522>3.0.co
https://doi.org/10.1002/1097-0142(19940301)73:5<1456::aid-cncr2820730522>3.0.co
Autor:
Zhong Zhong, Patrick Maunder, Mei Cong, Natalie Fursov, Jeffrey R. Haskins, Chandrasekaran Vasudevan, Mark Federici, Thomas Livelli
Publikováno v:
Assay and drug development technologies. 3(5)
As cell-based assays are used more commonly in robotic high-throughput compound screening, cells themselves have become critical reagents. Thus, it has become essential to produce cell reagents with high consistency and quality. We experimented with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078e9eb4fa9849599e7601c4726bf564
https://pubmed.ncbi.nlm.nih.gov/16305308
https://pubmed.ncbi.nlm.nih.gov/16305308
Autor:
Peter Haytko, Mei Cong, Thomas Livelli, Zhong Zhong, Mark Federici, Roland Tacke, Natalie Fursov, Michael Platchek
Publikováno v:
Assay and drug development technologies. 3(1)
In this article we describe the use of division-arrested cells for cell-based assays designed for high-throughput screening. Cells are the most critical and variable reagent for cell-based high-throughput screening. The robustness of robotic screenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24786fb2d833330c7e6aca75d8e7b6d3
https://pubmed.ncbi.nlm.nih.gov/15798391
https://pubmed.ncbi.nlm.nih.gov/15798391
Autor:
Chandrasekaran Vasudevan, Natalie Fursov, Patrick Maunder, Mei Cong, Mark Federici, Jeffrey R. Haskins, Thomas Livelli, Zhong Zhong
Publikováno v:
Assay & Drug Development Technologies; Oct2005, Vol. 3 Issue 5, p515-523, 9p
Autor:
Natalie Fursov, Mei Cong, Mark Federici, Michael Platchek, Peter Haytko, Roland Tacke, Thomas Livelli, Zhong Zhong
Publikováno v:
Assay & Drug Development Technologies; Feb2005, Vol. 3 Issue 1, p7-15, 9p