Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Mark D. Erion"'
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez-Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/d6d3fdb3039843b9b530ac94e6eb34d2
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez-Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Insulin analogs have been developed to treat diabetes with focus primarily on improving the time action profile without affecting ligand-receptor interaction or functional selectivity. As a result, inherent liabilities (e.g. hypoglycemia) of
Externí odkaz:
https://doaj.org/article/12bfc20a079d44f5b507280558359df6
Autor:
Eric S Muise, Hong-Ping Guan, Jinqi Liu, Andrea R Nawrocki, Xiaodong Yang, Chuanlin Wang, Carlos G Rodríguez, Dan Zhou, Judith N Gorski, Marc M Kurtz, Danqing Feng, Kenneth J Leavitt, Lan Wei, Robert R Wilkening, James M Apgar, Shiyao Xu, Ku Lu, Wen Feng, Ying Li, Huaibing He, Stephen F Previs, Xiaolan Shen, Margaret van Heek, Sandra C Souza, Mark J Rosenbach, Tesfaye Biftu, Mark D Erion, David E Kelley, Daniel M Kemp, Robert W Myers, Iyassu K Sebhat
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211568 (2019)
Physical activity promotes metabolic and cardiovascular health benefits that derive in part from the transcriptional responses to exercise that occur within skeletal muscle and other organs. There is interest in discovering a pharmacologic exercise m
Externí odkaz:
https://doaj.org/article/f28b2c263a184739b47d79a0d7b9272a
Autor:
Dmitri A. Pissarnitski, Ahmet Kekec, Lin Yan, Yuping Zhu, Danqing D. Feng, Pei Huo, Christina Madsen-Duggan, Christopher R. Moyes, Ravi P. Nargund, Terri Kelly, Xiaoping Zhang, Ester Carballo-Jane, Judith Gorski, Peter Zafian, Mo Qatanani, Niels Kaarsholm, Fanyu Meng, Xiujuan Jia, Keun-Joong Lee, Weixun Wang, Sherrie Xu, Michael J. Hohn, Michael J. Iammarino, Mark A. McCoy, Grace A. Okoh, Yingkai Liang, Scott A. Hollingsworth, Mark D. Erion, David E. Kelley, Robert M. Garbaccio, Amy Zhang, James Mu, Songnian Lin
Publikováno v:
Journal of Medicinal Chemistry. 65:5593-5605
We have identified a series of novel insulin receptor partial agonists (IRPAs) with a potential to mitigate the risk of hypoglycemia associated with the use of insulin as an antidiabetic treatment. These molecules were designed as dimers of native in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159d29e98accab17d5d9616e44812b0d
https://doi.org/10.1021/acs.jmedchem.1c02073
https://doi.org/10.1021/acs.jmedchem.1c02073
Autor:
Hong-Ping Guan, Xiaodong Yang, Ku Lu, Sheng-Ping Wang, Jose M. Castro-Perez, Stephen Previs, Michael Wright, Vinit Shah, Kithsiri Herath, Dan Xie, Daphne Szeto, Gail Forrest, Jing Chen Xiao, Oksana Palyha, Li-Ping Sun, Paula J. Andryuk, Samuel S. Engel, Yusheng Xiong, Songnian Lin, David E. Kelley, Mark D. Erion, Harry R. Davis, Liangsu Wang
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 11, Pp 2183-2195 (2015)
Glucagon and insulin have opposing action in governing glucose homeostasis. In type 2 diabetes mellitus (T2DM), plasma glucagon is characteristically elevated, contributing to increased gluconeogenesis and hyperglycemia. Therefore, glucagon receptor
Externí odkaz:
https://doaj.org/article/2172e3fff908429b99f72a94d0b8f239
Autor:
Margaret Wu, Ester Carballo-Jane, Haihong Zhou, Peter Zafian, Ge Dai, Mindy Liu, Julie Lao, Terri Kelly, Dan Shao, Judith Gorski, Dmitri Pissarnitski, Ahmet Kekec, Ying Chen, Stephen F. Previs, Giovanna Scapin, Yacob Gomez Llorente, Scott A. Hollingsworth, Lin Yan, Danqing Feng, Pei Huo, Geoffrey Walford, Mark D. Erion, David E. Kelley, Songnian Lin, James Mu
Publikováno v:
Nature communications. 13(1)
Insulin analogs have been developed to treat diabetes with focus primarily on improving the time action profile without affecting ligand-receptor interaction or functional selectivity. As a result, inherent liabilities (e.g. hypoglycemia) of injectab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1b1ab72351f303daeb431c6316f1a1
https://pubmed.ncbi.nlm.nih.gov/35177603
https://pubmed.ncbi.nlm.nih.gov/35177603
Autor:
Geoffrey Walford, Julie Lao, Terri M. Kelly, Haihong Zhou, Danqing Feng, Stephen F. Previs, Songnian Lin, Ahmet Kekec, Ying Chen, Mark D. Erion, Margaret Wu, Ester Carballo-Jane, Peter Zafian, Dmitri A. Pissarnitski, Pei Huo, James Mu, Scott A. Hollingsworth, Lin Yan, David E. Kelley, Mindy Liu, Ge Dai, Yacob Gomez-Llorente, Judith N. Gorski, Giovanna Scapin
Since its debut a century ago, insulin therapies have saved many lives and are now routinely used by patients with diabetes to manage hyperglycemia. Exemplary early studies of insulin molecular pathways led to the realization of the critical roles of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f553c0cd3d136dc33bbb79352a04f347
https://doi.org/10.21203/rs.3.rs-351091/v1
https://doi.org/10.21203/rs.3.rs-351091/v1
Autor:
Ying Li, Renato Felipe Pereira, J. Alan Maschek, Joseph L. Wilkerson, Annelise M Poss, Scott A. Summers, Vincent A. Kaddai, David E. Kelley, Xiaolan Shen, William L. Holland, Doris Hissako Sumida, Jared Rutter, Margaret Wu, Ying Qian, Jun Yao, Aleksandr Petrov, Graeme I. Lancaster, David G. McLaren, Trevor S. Tippetts, Liangsu Wang, Santhosh Satapati, Mackenzie J. Pearson, Christian N. Nunes, Rafael Mayoral Monibas, Heather Zhou, Liping Wang, Monowarul Mobin Siddique, Mark D. Erion, Stephen F. Previs, Bhagirath Chaurasia, C. Rufus Sweeney, Jinqi Liu, Ying Chen, James E. Cox, Andrew D. Howard
Publikováno v:
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Science
Made available in DSpace on 2019-10-06T17:15:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-26 American Diabetes Association American Heart Association Ben B. and Iris M. Margolis Foundation Diabetes Research Center, University of Washi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece126f2119f2026d40f42c46830040b
https://doi.org/10.1530/ey.17.15.11
https://doi.org/10.1530/ey.17.15.11
Autor:
Thomas P. Roddy, Gowri Bhat, Kithsiri Herath, Ling Kang, Sheo B. Singh, Stacey Conarello, Deborah Slipetz, David E. Kelley, Carlos G. Rodriguez, Andrea R. Nawrocki, Mark D. Erion, Stephen F. Previs, Jenna L. Terebetski
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 315:E63-E71
An increased contribution of de novo lipogenesis (DNL) may play a role in cases of dyslipidemia and adipose accretion; this suggests that inhibition of fatty acid synthesis may affect clinical phenotypes. Since it is not clear whether modulation of o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52dab4615e55e4404be4a1e697b609a0
https://doi.org/10.1152/ajpendo.00010.2017
https://doi.org/10.1152/ajpendo.00010.2017
Autor:
Margaret Wu, Aleksandr Petrov, Liangsu Wang, Yuyan Ding, Nina Xiaoyan Li, David E. Kelley, Ge Dai, Tamara Dlugos, Robert S. Sherwin, Harold B. Wood, Mark D. Erion, Liming Yang, Timothy J. Kowalski, Stacey N. Brown
Publikováno v:
Diabetes. 67:1401-1413
Insulin-induced hypoglycemia in diabetes is associated with impaired glucagon secretion. In this study, we tested whether stimulation of GPR119, a G-protein–coupled receptor expressed in pancreatic islet as well as enteroendocrine cells and previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4981c371f08d9e342dfee6b6a96fac96
https://doi.org/10.2337/db18-0031
https://doi.org/10.2337/db18-0031