Multimodal holographic microscopy: distinction between apoptosis and oncosis.

Autor: Jan Balvan, Aneta Krizova, Jaromir Gumulec, Martina Raudenska, Zbysek Sladek, Miroslava Sedlackova, Petr Babula, Marketa Sztalmachova, Rene Kizek, Radim Chmelik, Michal Masarik

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121674 (2015)

Identification of specific cell death is of a great value for many scientists. Predominant types of cell death can be detected by flow-cytometry (FCM). Nevertheless, the absence of cellular morphology analysis leads to the misclassification of cell d

Externí odkaz: https://doaj.org/article/3ba07150223d42578a5d0485b0fd3c4e

3D-printed biosensor with poly(dimethylsiloxane) reservoir for magnetic separation and quantum dots-based immunolabeling of metallothionein

Autor: Jan Zitka, Ondrej Zitka, Petr Hodek, Vojtech Adam, Pavel Kopel, Natalia Cernei, René Kizek, Sona Krizkova, Michal Masarik, Markéta Sztalmachová, Zbynek Heger

Publikováno v: ELECTROPHORESIS. 36:1256-1264

Currently, metallothioneins (MTs) are extensively investigated as the molecular biomarkers and the significant positive association of the MT amount was observed in tumorous versus healthy tissue of various types of malignant tumors, including head a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc21386307a5e98ad7abb70fbff7f1a6
https://doi.org/10.1002/elps.201400559

Modulation of Induced Cytotoxicity of Doxorubicin by Using Apoferritin and Liposomal Cages

Autor: Pavel Kopel, Lukas Nejdl, Lucia Knopfová, Markéta Sztalmachová, Martina Raudenská, Marie Stiborová, Michal Masarik, Jana Vlachova, René Kizek, Michaela Fojtu, Vojtech Adam, Petr Babula, Anna Skotakova, Sylvie Skalickova, Jaromír Gumulec

Publikováno v: International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 22960-22977 (2014)
International Journal of Molecular Sciences. 2014, vol. 15, issue 12, p. 22960-22977.
International Journal of Molecular Sciences
Volume 15
Issue 12
Pages 22960-22977

Doxorubicin is an effective chemotherapeutic drug, however, its toxicity is a significant limitation in therapy. Encapsulation of doxorubicin inside liposomes or ferritin cages decreases cardiotoxicity while maintaining anticancer potency. We synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8753f82b380068e0e53ea78a6c65a94a
https://doi.org/10.3390/ijms151222960

Cisplatin-resistant prostate cancer model: Differences in antioxidant system, apoptosis and cell cycle

Autor: Michal Masarik, Veronika Dvorakova, Martina Raudenská, Hana Polanska, René Kizek, Vojtech Adam, Jaromír Gumulec, Kristyna Hudcova, Lucia Knopfová, Jan Balvan, Petr Babula, Branislav Ruttkay-Nedecky, Marie Stiborová, Markéta Sztalmachová

Publikováno v: International Journal of Oncology. 44:923-933

Differences in the antioxidant system, apoptotic mechanism and in cell cycle between prostatic cell lines could partially elucidate the development of cisplatin resistance. The aim of this study was to identify the most characteristic parameter for a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858b727c88347589c6b7b23131912e62
https://doi.org/10.3892/ijo.2013.2223

Determination of oxidative stress and activities of antioxidant enzymes in guinea pigs treated with haloperidol

Autor: Branislav Ruttkay-Nedecky, Michal Masarik, Lukáš Pácal, Marián Hlavna, Marie Nováková, Vojtech Adam, Jiri Sochor, Martina Raudenská, Petr Babula, Markéta Sztalmachová, Jaromír Gumulec, Veronika Tanhäuserová, Tibor Stračina, Ondrej Zitka, René Kizek

Publikováno v: Experimental and Therapeutic Medicine

Guinea pigs (Cavia porcellus) were treated with haloperidol (HP), and free radical (FR) and ferric reducing antioxidant power (FRAP) assays were used to determine oxidative stress levels. Furthermore, the superoxide dismutase (SOD), glutathione reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd692f3de7e7fc71c99e8a1e4a10e03
https://doi.org/10.3892/etm.2012.822