Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Markéta Šmídková"'
Autor:
Santosh Kumar Adla, Barbora Slavikova, Hana Chodounska, Vojtech Vyklicky, Marek Ladislav, Pavla Hubalkova, Barbora Krausova, Tereza Smejkalova, Michaela Nekardova, Marketa Smidkova, Lenka Monincova, Radko Soucek, Ladislav Vyklicky, Eva Kudova
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Herein, we report the synthesis, structure-activity relationship study, and biological evaluation of neurosteroid inhibitors of N-methyl-D-aspartate receptors (NMDARs) receptors that employ an amide structural motif, relative to pregnanolone glutamat
Externí odkaz:
https://doaj.org/article/a55dc849289842f38467a237736ab7f8
Autor:
Jan Skácel, Stefan Djukic, Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský, Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt’ová, Zuzana Král’ová, Markéta Šmídková, Jan Voldřich, Michaela Rumlová, Petr Pachl, Jiří Brynda, Tereza Vučková, Milan Fábry, Jan Snášel, Iva Pichová, Pavlína Řezáčová, Helena Mertlíková-Kaiserová, Zlatko Janeba
Publikováno v:
Journal of Medicinal Chemistry. 66:6652-6681
Autor:
Jan Voldřich, Marika Matoušová, Markéta Šmídková, Barbora Slavíková, Hana Chodounská, Eva Kudová, Helena Mertlíková-Kaiserová
Publikováno v:
European journal of pharmacology. 927
The goal of this study was to evaluate mixed cortical and hippocampal primary rat postnatal neuronal culture as in vitro tool for identification of N-methyl-D-aspartate receptor (NMDAR) antagonists and to find out, whether this model is comparable wi
Autor:
Eva Kudova, Hana Chodounska, Pavla Hubalkova, Vojtech Vyklicky, Santosh Kumar Adla, Martin Svoboda, Markéta Šmídková, Kristina Holubova, Eva Tloušt’ová, Karel Vales, Milos Budesinsky, Michaela Nekardova, Barbora Krausova, Barbora Slavikova, Ladislav Vyklicky
Publikováno v:
Steroids. 117:52-61
Herein, we report a new class of amide-based inhibitors (1–4) of N-methyl- d -aspartate receptors (NMDARs) that were prepared as analogues of pregnanolone sulfate (PAS) and pregnanolone glutamate (PAG) – the steroidal neuroprotective NMDAR inhibi
Autor:
Helena Mertlíková-Kaiserová, Markéta Šmídková, Hana Chodounska, Santosh Kumar Adla, Barbora Slavikova, Marika Matousova, Eva Kudova, Miroslav Hájek
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 189
A broad variety of central nervous system diseases have been associated with glutamate induced excitotoxicity under pathological conditions. The neuroprotective effects of neurosteroids can combat this excitotoxicity. Herein, we have demonstrated the
Autor:
Marek Ladislav, Barbora Slavikova, Radko Souček, Eva Kudova, Barbora Krausova, Lenka Monincová, Pavla Hubalkova, Vojtech Vyklicky, Tereza Smejkalova, Hana Chodounska, Santosh Kumar Adla, Ladislav Vyklicky, Markéta Šmídková, Michaela Nekardova
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Herein, we report the synthesis, structure-activity relationship study, and biological evaluation of neurosteroid inhibitors of N-methyl-D-aspartate receptors (NMDARs) receptors that employ an amide structural motif, relative to pregnanolone glutamat
Autor:
Val J. Watts, Petra Břehová, Zlatko Janeba, Jan Skácel, Markéta Šmídková, Monica Soto Velasquez, Helena Mertlíková-Kaiserová, Martin Dračínský
Publikováno v:
ChemMedChem. 11:2534-2546
Bordetella pertussis adenylate cyclase toxin (ACT) and Bacillus anthracis edema factor (EF) are key virulence factors with adenylate cyclase (AC) activity that substantially contribute to the pathogenesis of whooping cough and anthrax, respectively.
Autor:
Milan Dejmek, Markéta Šmídková, Luděk Eyer, Radim Nencka, Daniel Růžek, Hubert Hřebabecký, Eliška Procházková, Eva Zborníková, Eva Tloušťová, Michal Šála
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:126897
The nucleoside/nucleotide derived antiviral agents have been the most important components of antiviral therapy used in clinics. Recently, the focus of the medicinal chemists within this exciting research field has been affected mainly by the lack of
Autor:
Jan Frydrych, Ramachandran Gnanasekaran, Jan Skácel, Zlatko Janeba, Markéta Šmídková, Martin Lepšík, Helena Mertlíková-Kaiserová, Val J. Watts, Martin Dračínský, Monica Soto-Velasquez
Publikováno v:
ChemMedChem. 13(2)
Inhibition of Bordetella pertussis adenylate cyclase toxin (ACT) and Bacillus anthracis edema factor (EF), key virulence factors with adenylate cyclase activity, represents a potential method for treating or preventing toxemia related to whooping cou
Autor:
Erik De Clercq, Markéta Šmídková, Luděk Eyer, Radim Nencka, Martin Palus, Jiří Neča, Daniel Růžek, Tomas Kastl
Publikováno v:
Antiviral research. 133
Tick-borne encephalitis (TBE) represents one of the most serious arboviral neuro-infections in Europe and northern Asia. As no specific antiviral therapy is available at present, there is an urgent need for efficient drugs to treat patients with TBE