Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Mark J. Holness"'
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fc0406f5c77ddc00636e0b6c928c0a3
https://doi.org/10.1016/b978-0-12-819460-7.00200-0
https://doi.org/10.1016/b978-0-12-819460-7.00200-0
Autor:
Jonas Bystrom, Jessica A Wray, Mary C Sugden, Mark J Holness, Karen E Swales, Timothy D Warner, Matthew L Edin, Darryl C Zeldin, Derek W Gilroy, David Bishop-Bailey
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26591 (2011)
Arachidonic acid is metabolized through three major metabolic pathways, the cyclooxygenase, lipoxygenase and CYP450 enzyme systems. Unlike cyclooxygenase and lipoxygenases, the role of CYP450 epoxygenases in monocyte/macrophage-mediated responses is
Externí odkaz:
https://doaj.org/article/48caab00b23e41049a4c13ab8e5fb4af
Autor:
Jessica A Wray, Mary C Sugden, Darryl C Zeldin, Gemma K Greenwood, Salma Samsuddin, Laura Miller-Degraff, J Alyce Bradbury, Mark J Holness, Timothy D Warner, David Bishop-Bailey
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7421 (2009)
Peroxisome proliferator-activated receptors (PPARs) are a family of three (PPARalpha, -beta/delta, and -gamma) nuclear receptors. In particular, PPARalpha is involved in regulation of fatty acid metabolism, cell growth and inflammation. PPARalpha med
Externí odkaz:
https://doaj.org/article/8417b0abe532426a9c9bb03ae953e418
Autor:
Noel G. Morgan, Marco Bugliani, Paul W. Caton, Mary C. Sugden, Julius Kieswich, Muhammad M. Yaqoob, Mark J. Holness, Sarah J. Richardson, Piero Marchetti, Michelle L. Holland
Publikováno v:
Diabetologia; Vol 56
Sirtuin (SIRT)3 is a mitochondrial protein deacetylase that regulates reactive oxygen species (ROS) production and exerts anti-inflammatory effects. As chronic inflammation and mitochondrial dysfunction are key factors mediating pancreatic beta cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8e757586d4334f1c5d8c62a2d654c9
https://doi.org/10.1007/s00125-013-2851-y
https://doi.org/10.1007/s00125-013-2851-y
Publikováno v:
Expert Review of Endocrinology & Metabolism. 7:191-208
AMP-activated protein kinase (AMPK) activity responds to a requirement to increase cellular ATP production and/or to conserve available ATP. AMPK is therefore central to the mechanisms of adjustment to fluctuating energy demand or metabolic substrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c971ca01313cbf97b32958b5b2ffa4
https://doi.org/10.1586/eem.12.9
https://doi.org/10.1586/eem.12.9
Publikováno v:
Diabetes, Obesity and Metabolism. 13:1097-1104
Aim: AMPK activates SIRT1 in liver and skeletal muscle. Impaired circadian function is associated with development of obesity. SIRT1 regulates circadian function and is suppressed in white adipose tissue (WAT) of obese patients. We examined the poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d73bf35a135c701e453c9cea829083
https://doi.org/10.1111/j.1463-1326.2011.01466.x
https://doi.org/10.1111/j.1463-1326.2011.01466.x
Publikováno v:
Diabetologia. 54:3083-3092
Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme for NAD(+) biosynthesis, exists as intracellular NAMPT (iNAMPT) and extracellular NAMPT (eNAMPT). eNAMPT, secreted from adipose tissue, promotes insulin secretion. Administratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35fa9df63303efd4ad83196067298ca
https://doi.org/10.1007/s00125-011-2288-0
https://doi.org/10.1007/s00125-011-2288-0
Publikováno v:
Current Diabetes Reviews. 7:336-345
The impact of bariatric surgery on insulin sensitivity and glucose tolerance has refocused interest in the role of gut-derived factors in the regulation of insulin secretion and action. The incretins, glucose-dependent insulinotropic peptide (GIP) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3d3f5269edae1e74b931b3479e4b6df
https://doi.org/10.2174/157339911797415602
https://doi.org/10.2174/157339911797415602
Publikováno v:
Biochemical Journal. 437:521-530
LXR (liver X receptor) and PPARα (peroxisome-proliferator-activated receptor α) are nuclear receptors that control the expression of genes involved in glucose and lipid homoeostasis. Using wild-type and PPARα-null mice fed on an LXR-agonist-supple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0d8eb6de439ed60102b8f3fec51078
https://doi.org/10.1042/bj20110702
https://doi.org/10.1042/bj20110702
Publikováno v:
Nutrition. 26:491-501
Environmental factors can influence the acute and longer-term risks of developing diseases, including type 2 diabetes mellitus and cardiovascular disease; however, the underlying mechanism remains elusive. Increasing evidence suggests that these effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acdf52de4b83dd2b55472c81fcad937b
https://doi.org/10.1016/j.nut.2009.09.012
https://doi.org/10.1016/j.nut.2009.09.012