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Development of an UPLC/MS–MS method for quantification of intact IGF-I from human serum

Autor: Nikunj Tanna, Mark Wrona, Mary E. Lame

Publikováno v: Bioanalysis. 12:53-65

Aim: Developing LC–MS methods for biomolecules is often challenging due to issues with molecular size and complexity, nonspecific binding, protein binding, solubility and sensitivity. As a result, complex sample preparation workflows, including imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7210a5c3e5bb8a8c9c62b046b055a556
https://doi.org/10.4155/bio-2019-0234

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Microflow UPLC and high-resolution MS as a sensitive and robust platform for quantitation of intact peptide hormones

Autor: Christopher A. Evans, Matthew Szapacs, Jonathan R Kehler, Zhuo Chen, Mark Wrona, Yun Alelyunas

Publikováno v: Bioanalysis. 11:1275-1289

Aim: Recent advances in microflow ultra performance liquid chromatography (UPLC) systems offer higher sensitivity with robustness to meet the routine bioanalytical demands. Modern high-resolution mass spectrometers (HRMS) enable the development of hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1800ec60c02b033f8e1d3b7969350fa9
https://doi.org/10.4155/bio-2019-0081

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Intact mAb LC-MS for drug concentration from pre-clinical studies: bioanalytical method performance and in-life samples

Autor: Nicole A Schneck, Matthew Szapacs, Yun Alelyunas, Ian Edwards, Henry Shion, Josh Albert, Caroline J. Sychterz, Zhuo Chen, Mark Wrona, John F. Kellie

Publikováno v: Bioanalysis. 12(19)

Background: Antibody biotherapeutic measurement from pharmacokinetic studies has not been traditionally based on intact molecular mass as is the case for small molecules. However, recent advancements in protein capture and mass spectrometer technolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52677a950e29502066c86eb5c7373b0e
https://pubmed.ncbi.nlm.nih.gov/32975433

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Metabolite identification using an ion mobility enhanced data‐independent acquisition strategy and automated data processing

Autor: Mark Wrona, Ismael Zamora, Mark T. Cancilla, Tatiana Radchenko, Gordon Murray, Christopher J. Kochansky, Jayne Kirk, Fabien Fontaine, Russell J. Mortishire-Smith

Publikováno v: Rapid Communications in Mass Spectrometry. 34

Rationale Liquid chromatography/mass spectrometry is an essential tool for efficient and reliable quantitative and qualitative analysis and underpins much of contemporary drug metabolism and pharmacokinetics. Data-independent acquisition methods such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04ab39241b52267fdfd8609f6fbc023
https://doi.org/10.1002/rcm.8792

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Development and application of sub-2-μm particle CO2-based chromatography coupled to mass spectrometry for comprehensive analysis of lipids in cottonseed extracts

Autor: Giorgis Isaac, Vladimir Shulaev, Drew Sturtevant, Janna Crossley, Michael D. Jones, Kent D. Chapman, Patrick J. Horn, Khadiza Zaman, Mark Wrona, Norman W. Smith, Carolina Salazar

Publikováno v: Rapid Communications in Mass Spectrometry. 31:591-605

RATIONALE Refined cottonseed oil has widespread applications in the food and chemical industries. Although the major lipids comprising cottonseed oil (triacylglycerols) are well known, there are many diverse lipid species in cotton seeds that occur a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eeb18edf5abcd3f2e224e21c6ac8aefd
https://doi.org/10.1002/rcm.7825

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