Výsledky vyhledávání - "Mark, Wasley"

Akademický článek

Combining a nanoparticle-mediated immunoradiotherapy with dual blockade of LAG3 and TIGIT improves the treatment efficacy in anti-PD1 resistant lung cancer

Publikováno v: Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-19 (2022)

Abstract Background While improvements in immunoradiotherapy have significantly improved outcomes for cancer patients, this treatment approach has nevertheless proven ineffective at controlling the majority of malignancies. One of the mechanisms of r

Externí odkaz: https://doaj.org/article/a090d791bef0465c93bf5eb25e2451f7

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Akademický článek

A radioenhancing nanoparticle mediated immunoradiation improves survival and generates long-term antitumor immune memory in an anti-PD1-resistant murine lung cancer model

Autor: Yun Hu, Sébastien Paris, Hampartsoum Barsoumian, Chike O. Abana, Kewen He, Duygu Sezen, Mark Wasley, Fatemeh Masrorpour, Dawei Chen, Liangpeng Yang, Joe D. Dunn, Saumil Gandhi, Quynh-Nhu Nguyen, Maria Angelica Cortez, James W. Welsh

Publikováno v: Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-14 (2021)

Abstract Background Combining radiotherapy with PD1 blockade has had impressive antitumor effects in preclinical models of metastatic lung cancer, although anti-PD1 resistance remains problematic. Here, we report results from a triple-combination the

Externí odkaz: https://doaj.org/article/07dc075fcbd049008b2e635b70dfaf0b

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Akademický článek

Pulsed radiotherapy to mitigate high tumor burden and generate immune memory

Autor: Duygu Sezen, Hampartsoum B. Barsoumian, Kewen He, Yun Hu, Qi Wang, Chike O. Abana, Nahum Puebla-Osorio, Ethan Y. Hsu, Mark Wasley, Fatemeh Masrorpour, Jing Wang, Maria Angelica Cortez, James W. Welsh

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Radiation therapy (XRT) has a well-established role in cancer treatment. Given the encouraging results on immunostimulatory effects, radiation has been increasingly used with immune-check-point inhibitors in metastatic disease, especially when immuno

Externí odkaz: https://doaj.org/article/20ba2088e44043fcbe418952fcb64974

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Akademický článek

Addition of TLR9 agonist immunotherapy to radiation improves systemic antitumor activity

Autor: Ahmed I. Younes, Hampartsoum B. Barsoumian, Duygu Sezen, Vivek Verma, Roshal Patel, Mark Wasley, Yun Hu, Joe D. Dunn, Kewen He, Dawei Chen, Hari Menon, Fatemeh Masrorpour, Meidi Gu, Liangpeng Yang, Nahum Puebla-Osorio, Maria Angelica Cortez, James W. Welsh

Publikováno v: Translational Oncology, Vol 14, Iss 2, Pp 100983- (2021)

Radiotherapy (RT) has been used to control tumors by physically damaging DNA and inducing apoptosis; it also promotes antitumor immune responses via neoantigens release and augmenting immune-oncology agents to elicit systemic response. Tumor regressi

Externí odkaz: https://doaj.org/article/804f3de3e7644ceb9a234f76d8d52b61

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Akademický článek

Response and outcomes after anti-CTLA4 versus anti-PD1 combined with stereotactic body radiation therapy for metastatic non-small cell lung cancer: retrospective analysis of two single-institution prospective trials

Autor: James Welsh, Hari Menon, Dawei Chen, Rishab Ramapriyan, Vivek Verma, Maria Angelica Cortez, Chunxiao Guo, Hampartsoum Barsoumian, Ahmed Younes, Yun Hu, Mark Wasley

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Background This study compared response rates and outcomes of combined radiotherapy and immunotherapy (iRT) based on the type of checkpoint inhibitor (anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA4) vs antiprogrammed death-1 (PD1)) for metas

Externí odkaz: https://doaj.org/article/234e2a69d0af4182b9b53262ae2884fe

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