Výsledky vyhledávání - "Mark, Waltham"

Akademický článek

Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system

Autor: Razan Wafai, Elizabeth D. Williams, Emma de Souza, Peter T. Simpson, Amy E. McCart Reed, Jamie R. Kutasovic, Mark Waltham, Cameron E. Snell, Tony Blick, Erik W. Thompson, Honor J. Hugo

Publikováno v: Breast Cancer Research, Vol 22, Iss 1, Pp 1-21 (2020)

Abstract Background Breast cancers acquire aggressive capabilities via epithelial to mesenchymal transition (EMT), in which various integrins/integrin-linked kinase signalling are upregulated. Methods We investigated this in two patient-derived xenog

Externí odkaz: https://doaj.org/article/d8e49afd20eb46449f29b70a6451d3b0

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Molecular associations of response to the new generation BTK inhibitor zanubrutinib in marginal zone lymphoma

Autor: Maciej Tatarczuch, Mark Waltham, Jake Shortt, Galina Polekhina, Eliza A Hawkes, Shir-Jing Ho, Judith Trotman, Daniella Brasacchio, Melannie Co, Jessica Li, Vanitha Ramakrishnan, Karin Dunne, Stephen S. Opat, Gareth P. Gregory

Publikováno v: Blood Advances.

Utilising tissue whole exome sequencing (WES) and circulating tumor cell-free DNA (ctDNA), this Australasian Leukaemia & Lymphoma Group (ALLG) translational study sought to characterise primary and acquired molecular determinants of response and resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34749dc35985ef09fbc8f3ce50e21131
https://doi.org/10.1182/bloodadvances.2022009412

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Autor: Erik W. Thompson, Razan Wafai, Jamie R. Kutasovic, Mark Waltham, Emma de Souza, Cameron Snell, Peter T. Simpson, Amy E. McCart Reed, Tony Blick, Honor J. Hugo, Elizabeth D. Williams

Publikováno v: Breast Cancer Research, Vol 22, Iss 1, Pp 1-21 (2020)
Breast Cancer Research : BCR

BackgroundBreast cancers acquire aggressive capabilities via epithelial to mesenchymal transition (EMT), in which various integrins/integrin-linked kinase signalling are upregulated.MethodsWe investigated this in two patient-derived xenografts (PDXs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7807f55841810ff1ae16fd05fa06dc
https://doaj.org/article/d8e49afd20eb46449f29b70a6451d3b0

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Human-specific RNA analysis shows uncoupled epithelial-mesenchymal plasticity in circulating and disseminated tumour cells from human breast cancer xenografts

Autor: Alexander Dobrovic, Emma L. de Sousa, Erik W. Thompson, Mark Waltham, Anthony Tachtsidis, Anh Viet-Phuong Le, Tony Blick, Devika Gunasinghe

Publikováno v: Clinical & Experimental Metastasis. 36:393-409

Blood samples, bone marrow, tumours and metastases where possible were collected from SCID mice bearing orthotopic xenografts of the triple-negative MDA-MB-468 cell line or a transplantable ER-positive patient derived xenograft (ED-03), and assessed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f57aa9ff32a3ae1d6a253e99f4c740
https://doi.org/10.1007/s10585-019-09977-y

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Identifying Therapies to Combat Epithelial Mesenchymal Plasticity-Associated Chemoresistance to Conventional Breast Cancer Therapies Using An shRNA Library Screen

Autor: Kaylene J. Simpson, Mark Waltham, Shivashankar H. Nagaraj, James Monkman, Adrian P. Wiegmans, Erik W. Thompson, Tony Blick, Izhak Haviv, Cletus Pinto, Sugandha Bhatia, Ekaterina Ivanova, Pamela M. Pollock

Publikováno v: Cancers, Vol 12, Iss 1123, p 1123 (2020)
Cancers
Volume 12
Issue 5

Background: Breast cancer (BC) is a heterogeneous disease for which the commonly used chemotherapeutic agents primarily include the anthracyclines (doxorubicin, epirubicin), microtubule inhibitors (paclitaxel, docetaxel, eribulin), and alkylating age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5d45fba08a0c2a0a22ef179fd8f0b4
https://www.mdpi.com/2072-6694/12/5/1123

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Akademický článek

An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer.

Autor: Manisha Shah, Dexing Huang, Tony Blick, Andrea Connor, Lawrence A Reiter, Joel R Hardink, Conor C Lynch, Mark Waltham, Erik W Thompson

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e29615 (2012)

We investigated the effects of the matrix metalloproteinase 13 (MMP13)-selective inhibitor, 5-(4-{4-[4-(4-fluorophenyl)-1,3-oxazol-2-yl]phenoxy}phenoxy)-5-(2-methoxyethyl) pyrimidine-2,4,6(1H,3H,5H)-trione (Cmpd-1), on the primary tumor growth and br

Externí odkaz: https://doaj.org/article/403a71d5b97340b1adaf0dad03567717

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Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

Autor: Erik W. Thompson, Christine Gilles, Tony Blick, Honor J. Hugo, T Tanaka, Prue Hill, Brett G. Hollier, Npad Gunasinghe, A Toh, Mark Waltham

Publikováno v: Breast Cancer Research, Vol 19, Iss 1, Pp 1-25 (2017)
Breast Cancer Research : BCR

Background Epithelial-to-mesenchymal transition (EMT) is associated with downregulated E-cadherin and frequently with decreased proliferation. Proliferation may be restored in secondary metastases by mesenchymal-to-epithelial transition (MET). We tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e943de15f6a8fc5db6b36c74b6e1c04
http://link.springer.com/article/10.1186/s13058-017-0880-z

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