Electronic alerts for acute kidney injury across primary and secondary care

Autor: Emma Vaux, Daniel Lasserson, Joseph Barker, Karl Smith-Byrne, Oliver Sayers, Krishan Joseph, Mark Sleeman

Publikováno v: BMJ Open Quality, Vol 10, Iss 2 (2021)

Problem In 2009 the National Confidential Enquiry into Patient Outcome and Death suggested only 50% of patients with acute kidney injury (AKI) receive good standards of care. In response National Health Service (NHS) England mandated the use of elect

Externí odkaz: https://doaj.org/article/5d50bb69915742f8b31c53ad6338c01c

IL-6–GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models

Autor: Marisa Carbonaro, Kehui Wang, Hui Huang, Davor Frleta, Aditi Patel, Alexander Pennington, Mathieu Desclaux, Sven Moller-Tank, Justin Grindley, Judith Altarejos, Jun Zhong, Greg Polites, William Poueymirou, Stephen Jaspers, Christos Kyratsous, Brian Zambrowicz, Andrew Murphy, John C. Lin, Lynn E. Macdonald, Christopher Daly, Mark Sleeman, Gavin Thurston, Zhe Li

Publikováno v: Science Advances. 9

Liver steatosis is an increasing health issue with few therapeutic options, partly because of a paucity of experimental models. In humanized liver rodent models, abnormal lipid accumulation in transplanted human hepatocytes occurs spontaneously. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::944cb1b84f4b1e58d4f3d83c7e56e4a6
https://doi.org/10.1126/sciadv.adf4490

Germline Mutations in

Autor: Niek, Verweij, Mary E, Haas, Jonas B, Nielsen, Olukayode A, Sosina, Minhee, Kim, Parsa, Akbari, Tanima, De, George, Hindy, Jonas, Bovijn, Trikaldarshi, Persaud, Lawrence, Miloscio, Mary, Germino, Lampros, Panagis, Kyoko, Watanabe, Joelle, Mbatchou, Marcus, Jones, Michelle, LeBlanc, Suganthi, Balasubramanian, Craig, Lammert, Sofia, Enhörning, Olle, Melander, David J, Carey, Christopher D, Still, Tooraj, Mirshahi, Daniel J, Rader, Prodromos, Parasoglou, Johnathon R, Walls, John D, Overton, Jeffrey G, Reid, Aris, Economides, Michael N, Cantor, Brian, Zambrowicz, Andrew J, Murphy, Goncalo R, Abecasis, Manuel A R, Ferreira, Eriks, Smagris, Viktoria, Gusarova, Mark, Sleeman, George D, Yancopoulos, Jonathan, Marchini, Hyun M, Kang, Katia, Karalis, Alan R, Shuldiner, Giusy, Della Gatta, Adam E, Locke, Aris, Baras, Luca A, Lotta

Publikováno v: The New England journal of medicine. 387(4)

Exome sequencing in hundreds of thousands of persons may enable the identification of rare protein-coding genetic variants associated with protection from human diseases like liver cirrhosis, providing a strategy for the discovery of new therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::108692950480467401d0a774b2ebec90
https://pubmed.ncbi.nlm.nih.gov/35939579

Contributors

Autor: Michael J. Adkesson, Amy Alexander, Jill Allread, Cheryl Asa, Anne E. Ballmann, Ursula Bechert, Roy G. Bengis, Rui I. Bernardino, Sally Boutelle, Elizabeth L. Buckles, Mitchell Bush, Peter E. Buss, Kenneth N. Cameron, Norin Chai, Scott B. Citino, Robert A. Cook, Graham Crawshaw, Carolyn Cray, Mark W. Cunningham, Sharon L. Deem, Ann Duncan, Gregory J. Fleming, Deidre K. Fontenot, Jeanette Fuller, Laurie J. Gage, Kathryn C. Gamble, Brett Gartrell, Martin Gilbert, Gwendolyn Griffith, Catherine Hadfield, Elizabeth E. Hammond, Jean-Michel Hatt, Michelle G. Hawkins, Gary S. Hayward, Dean A. Hendrickson, Robert Hermes, Sonia M. Hernandez, Thomas Bernd Hildebrandt, Robert Hilsenroth, Peter H. Holz, Lauren L. Howard, Ramiro Isaza, Richard Jakob-Hoff, Stephanie B. James, Donald L. Janssen, Christine K. Johnson, Randall E. Junge, Olga Martin Jurado, Jacques Kaandorp, Petra Kaczensky, William B. Karesh, Gretchen E. Kaufman, David E. Kenny, Pia Krawinkel, Andreas Kurth, Nadine Lamberski, William R. Lance, Jennifer N. Langan, Iris I. Levin, Mark Lynn Lloyd, Lesa Longley, Linda Lowenstein, Imke Lueders, Elizabeth J.B. Manning, Jonna A.K. Mazet, James F. McBain, Stephanie McCain, Rita McManamon, Thomas P. Meehan, Carol Uphoff Meteyer, James E. Miller, Michele A. Miller, Hayley Weston Murphy, Natalie D. Mylniczenko, Nicole M. Nemeth, Andreas Nitsche, Terry M. Norton, J. Lindsay Oaks, Justine O’Brien, Patricia G. Parker, Joanne Paul-Murphy, Linda M. Penfold, Allan P. Pessier, Johann 'Joost' Philippa, Shane R. Raidal, Edward C. Ramsay, Leslie Anne Reddacliff, Patricia E. Reed, Laura K. Richman, Gary Riggs, Nadia Robert, David A. Rubin, Charles E. Rupprecht, Stephanie Sanderson, Michael Schlegel, Kent J. Semmen, Jessica L. Siegal-Willott, Michelle L. Skurski, Dennis Slate, Jonathan Mark Sleeman, Andrea Brenes Soto, M. Andrew Stamper, Hanspeter W. Steinmetz, Mark Stetter, Jeffrey L. Stott, Cynthia Stringfield, Meg Sutherland Smith, Susan J. Tornquist, Eduardo V. Valdes, Michael T. Walsh, Christian Walzer, Kristen S. Warren, Martha A. Weber, Jim Wellehan, Christian J. Wenker, Ellen Wiedner, Pat Witman, Michael J. Yabsley, Nina Zimmermann, Jeffery R. Zuba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bd2f90cc5c0915912504ccafc732261
https://doi.org/10.1016/b978-1-4377-1986-4.00086-x