Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mark, Penney"'
Autor:
Azar Shahraz, Mark Penney, Juliana Candido, Grace Opoku‐Ansah, Melanie Neubauer, Jim Eyles, Oluwaseun Ojo, Nelson Liu, Nadia M. Luheshi, Alex Phipps, Karthick Vishwanathan
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 10, Pp 1670-1681 (2024)
Abstract AZD0171 (INN: Falbikitug) is being developed as a humanized monoclonal antibody (mAb), immunoglobulin G subclass 1 (IgG1), which binds specifically to the immunosuppressive human cytokine leukemia inhibitory factor (LIF) and inhibits downstr
Externí odkaz:
https://doaj.org/article/654650c22c3e43b7a045471ce1fdd1d4
Autor:
Elizabeth England, D. Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T. Y. Chan, Catherine E. Chaillan Huntington, Kirsty F. Houslay, Teodor Erngren, Mark Penney, Jayesh B. Majithiya, Laura Rapley, Dorothy A. Sims, Claire Hollins, Elizabeth C. Hinchy, Martin D. Strain, Benjamin P. Kemp, Dominic J. Corkill, Richard D. May, Katherine A. Vousden, Robin J. Butler, Tomas Mustelin, Tristan J. Vaughan, David C. Lowe, Caroline Colley, E. Suzanne Cohen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for treatment of inflammatory disease. Here, we describe the identification of tozora
Externí odkaz:
https://doaj.org/article/4d1e1f2da3f148aa85e1df6a32f0ef69
Autor:
John D. Bagert, Vaheh Oganesyan, Chi-I Chiang, Mike Iannotti, Jia Lin, Chunning Yang, Sterling Payne, Will McMahon, Samuel Edwards, Andrew Dippel, Mark Hutchinson, Fengying Huang, Vineela Aleti, Chendi Niu, Chen Qian, Jessica Denham, Sofia Ferreira, Pallab Pradhan, Mark Penney, Chunlei Wang, Wenhai Liu, Even Walseng, Yariv Mazor
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTBispecific antibodies represent an increasingly large fraction of biologics in therapeutic development due to their expanded scope in functional capabilities. Asymmetric monovalent bispecific IgGs (bsIgGs) have the additional advantage of mai
Externí odkaz:
https://doaj.org/article/2704cd42c0734221bbfa24115f8720e9
Autor:
Timothy Dreyer, Mittal Shah, Carl Doyle, Kevin Greenslade, Mark Penney, Paul Creeke, Apoorva Kotian, Hua Zhu Ke, Vinny Naidoo, Gill Holdsworth
Publikováno v:
Journal of Orthopaedic Translation, Vol 29, Iss , Pp 134-142 (2021)
Background: Sclerosteosis, a severe autosomal recessive sclerosing skeletal dysplasia characterised by excessive bone formation, is caused by absence of sclerostin, a negative regulator of bone formation that binds LRP5/6 Wnt co-receptors. Current tr
Externí odkaz:
https://doaj.org/article/44e57dc8a4744eafaa88a71c09f93a5a
Autor:
Erica L. Bradshaw, Mary E. Spilker, Richard Zang, Loveleena Bansal, Handan He, Rhys D.O. Jones, Kha Le, Mark Penney, Edgar Schuck, Brian Topp, Alice Tsai, Christine Xu, Marjoleen J.M.A. Nijsen, Jason R. Chan
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 11, Pp 777-791 (2019)
Abstract Quantitative systems pharmacology (QSP) approaches have been increasingly applied in the pharmaceutical since the landmark white paper published in 2011 by a National Institutes of Health working group brought attention to the discipline. In
Externí odkaz:
https://doaj.org/article/cfab4d71279e43a58805b6626dcdac0c
Autor:
Lourdes Cucurull‐Sanchez, Michael J. Chappell, Vijayalakshmi Chelliah, S. Y. Amy Cheung, Gianne Derks, Mark Penney, Alex Phipps, Rahuman S. Malik‐Sheriff, Jon Timmis, Marcus J. Tindall, Piet H. van derGraaf, Paolo Vicini, James W. T. Yates
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 5, Pp 259-272 (2019)
The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts. This in turn undermin
Externí odkaz:
https://doaj.org/article/293fdfa59097477883b9efaa13afb99e
Autor:
Peter M. A. Calverley, Sanjay Sethi, Michelle Dawson, Christine K. Ward, Donna K. Finch, Mark Penney, Paul Newbold, René van der Merwe
Publikováno v:
Respiratory Research, Vol 18, Iss 1, Pp 1-12 (2017)
Abstract Background Interleukin-1 receptor 1 (IL-1R1) inhibition is a potential strategy for treating patients with chronic obstructive pulmonary disease (COPD). MEDI8968, a fully human monoclonal antibody, binds selectively to IL-1R1, inhibiting act
Externí odkaz:
https://doaj.org/article/d8fa46126d114930b6eb759ebbd0bc80
Autor:
Elizabeth England, D. Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T. Y. Chan, Catherine E. Chaillan Huntington, Kirsty F. Houslay, Teodor Erngren, Mark Penney, Jayesh B. Majithiya, Laura Rapley, Dorothy A. Sims, Claire Hollins, Elizabeth C. Hinchy, Martin D. Strain, Benjamin P. Kemp, Dominic J. Corkill, Richard D. May, Katherine A. Vousden, Robin J. Butler, Tomas Mustelin, Tristan J. Vaughan, David C. Lowe, Caroline Colley, E. Suzanne Cohen
Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for treatment of inflammatory disease. Here, we describe the identification of tozorakimab (ME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2623b7a64721c16cead1782c6553f513
https://doi.org/10.1101/2023.02.28.527262
https://doi.org/10.1101/2023.02.28.527262
Autor:
Marco Merkli, Mark Penney
Publikováno v:
Mathematics, Vol 3, Iss 1, Pp 92-118 (2015)
We investigate the process of quantum measurements on scattered probes. Before scattering, the probes are independent, but they become entangled afterwards, due to the interaction with the scatterer. The collection of measurement results (the history
Externí odkaz:
https://doaj.org/article/b3218922c12241b9a83537e110917daa
Autor:
Apoorva Kotian, Mari Davies, Prabha Peramuhendige, Nenad Manevski, Melanie Golding, Syeda Shah, Mark Penney, Lloyd King
Publikováno v:
Drug Metabolism and Disposition. 48:1169-1182
Although intestinal metabolism plays an important role in drug disposition, early predictions of human outcomes are challenging, in part because of limitations of available in vitro models. To address this, we have evaluated three in vitro models of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cba88c73dd7e073a20460be1ac266f7
https://doi.org/10.1124/dmd.120.000111
https://doi.org/10.1124/dmd.120.000111