Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Mark, Peakman"'
Autor:
Jerod L. Ptacin, Lina Ma, Carolina E. Caffaro, Nicole V. Acuff, Kristine Germar, Peter Severy, Yanyan Qu, Jose-Luis Vela, Xinming Cai, Kristine M. San Jose, Hans R. Aerni, David B. Chen, Ean Esche, Taylor K. Ismaili, Rob Herman, Yelena Pavlova, Michael J. Pena, Jasmine Nguyen, Lilia K. Koriazova, Laura K. Shawver, Ingrid B. Joseph, Jill Mooney, Mark Peakman, Marcos E. Milla
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-16 (2024)
Abstract Background Natural cytokines are poorly suited as therapeutics for systemic administration due to suboptimal pharmacological and pharmacokinetic (PK) properties. Recombinant human interleukin-2 (rhIL-2) has shown promise for treatment of aut
Externí odkaz:
https://doaj.org/article/224e433676bd420da232e1c317680a2d
Autor:
Latif Rachdi, Zhicheng Zhou, Claire Berthault, Chloe Lourenço, Alexis Fouque, Thomas Domet, Mathieu Armanet, Sylvaine You, Mark Peakman, Roberto Mallone, Raphael Scharfmann
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104740- (2023)
Summary: Background: To resist the autoimmune attack characteristic of type 1 diabetes, insulin producing pancreatic β cells need to evade T-cell recognition. Such escape mechanisms may be conferred by low HLA class I (HLA-I) expression and upregula
Externí odkaz:
https://doaj.org/article/c606494ecc3c41ff9dd6a8dbda428a1a
Autor:
Tomi Suomi, Inna Starskaia, Ubaid Ullah Kalim, Omid Rasool, Maria K. Jaakkola, Toni Grönroos, Tommi Välikangas, Caroline Brorsson, Gianluca Mazzoni, Sylvaine Bruggraber, Lut Overbergh, David Dunger, Mark Peakman, Piotr Chmura, Søren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L. Elo, Pieter Gillard, Kristina Casteels, Lutgart Overbergh, Chris Wallace, Mark Evans, Ajay Thankamony, Emile Hendriks, Loredana Marcoveccchio, Timothy Tree, Noel G. Morgan, Sarah Richardson, John A. Todd, Linda Wicker, Adrian Mander, Colin Dayan, Mohammad Alhadj Ali, Thomas Pieber, Decio L. Eizirik, Myriam Cnop, Flemming Pociot, Jesper Johannesen, Peter Rossing, Cristina Legido Quigley, Roberto Mallone, Raphael Scharfmann, Christian Boitard, Timo Otonkoski, Riitta Veijola, Matej Oresic, Jorma Toppari, Thomas Danne, Anette G. Ziegler, Peter Achenbach, Teresa Rodriguez-Calvo, Michele Solimena, Ezio E. Bonifacio, Stephan Speier, Reinhard Holl, Francesco Dotta, Francesco Chiarelli, Piero Marchetti, Emanuele Bosi, Stefano Cianfarani, Paolo Ciampalini, Carine De Beaufort, Knut Dahl-Jørgensen, Torild Skrivarhaug, Geir Joner, Lars Krogvold, Przemka Jarosz-Chobot, Tadej Battelino, Bernard Thorens, Martin Gotthardt, Bart O. Roep, Tanja Nikolic, Arnaud Zaldumbide, Ake Lernmark, Marcus Lundgren, Guillaume Costacalde, Thorsten Strube, Almut Nitsche, Jose Vela, Matthias Von Herrath, Johnna Wesley, Antonella Napolitano-Rosen, Melissa Thomas, Nanette Schloot, Allison Goldfine, Frank Waldron-Lynch, Jill Kompa, Aruna Vedala, Nicole Hartmann, Gwenaelle Nicolas, Jean van Rampelbergh, Nicolas Bovy, Sanjoy Dutta, Jeannette Soderberg, Simi Ahmed, Frank Martin, Esther Latres, Gina Agiostratidou, Anne Koralova, Ruben Willemsen, Anne Smith, Binu Anand, Vipan Datta, Vijith Puthi, Sagen Zac-Varghese, Renuka Dias, Premkumar Sundaram, Bijay Vaidya, Catherine Patterson, Katharine Owen, Barbara Piel, Simon Heller, Tabitha Randell, Tasso Gazis, Elise Bismuth Reismen, Jean-Claude Carel, Jean-Pierre Riveline, Jean-Francoise Gautier, Fabrizion Andreelli, Florence Travert, Emmanuel Cosson, Alfred Penfornis, Catherine Petit, Bruno Feve, Nadine Lucidarme, Jean-Paul Beressi, Catherina Ajzenman, Alina Radu, Stephanie Greteau-Hamoumou, Cecile Bibal, Thomas Meissner, Bettina Heidtmann, Sonia Toni, Birgit Rami-Merhar, Bart Eeckhout, Bernard Peene, N. Vantongerloo, Toon Maes, Leen Gommers
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104625- (2023)
Summary: Background: Type 1 diabetes is a complex heterogenous autoimmune disease without therapeutic interventions available to prevent or reverse the disease. This study aimed to identify transcriptional changes associated with the disease progress
Externí odkaz:
https://doaj.org/article/2c41bdea112542e1901b5cf0742fc2e4
Autor:
Sefina Arif, Irma Pujol-Autonell, Yogesh Kamra, Evangelia Williams, Norkhairin Yusuf, Clara Domingo-Vila, Yasaman Shahrabi, Emily Pollock, Leena Khatri, Mark Peakman, Timothy Tree, Anna Lorenc
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
AimsRecent studies highlight the potentially important role of neoepitopes in breaking immune tolerance in type 1 diabetes. T cell reactivity to these neoepitopes has been reported, but how this response compares quantitatively and phenotypically wit
Externí odkaz:
https://doaj.org/article/f945964b44d541e4ba421761e7916752
Autor:
Sarah E. Mann, Zhicheng Zhou, Laurie G. Landry, Amanda M. Anderson, Aimon K. Alkanani, Jeremy Fischer, Mark Peakman, Roberto Mallone, Kristen Campbell, Aaron W. Michels, Maki Nakayama
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Recent advancements in single cell sequencing technologies allow for identification of numerous immune-receptors expressed by T cells such as tumor-specific and autoimmune T cells. Determining antigen specificity of those cells holds immense therapeu
Externí odkaz:
https://doaj.org/article/1ad9f4fd08954056b50904453b43f4fa
Autor:
Thomas Whalley, Garry Dolton, Paul E. Brown, Aaron Wall, Linda Wooldridge, Hugo van den Berg, Anna Fuller, Jade R. Hopkins, Michael D. Crowther, Meriem Attaf, Robin R. Knight, David K. Cole, Mark Peakman, Andrew K. Sewell, Barbara Szomolay
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The strong links between (Human Leukocyte Antigen) HLA, infection and autoimmunity combine to implicate T-cells as primary triggers of autoimmune disease (AD). T-cell crossreactivity between microbially-derived peptides and self-peptides has been sho
Externí odkaz:
https://doaj.org/article/1a8fe277e505431893c2b64061e4a518
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
T cell receptors are generated by somatic gene recombination, and are normally selected against autoreactivity. Here the authors show that CD4 T cells from patients with autoimmune type 1 diabetes have shorter TCRβ sequences, broader repertoire dive
Externí odkaz:
https://doaj.org/article/380b4cadc81944b194b1293a9b9b42f5
Autor:
Jose Juan Almagro Armenteros, Caroline Brorsson, Christian Holm Johansen, Karina Banasik, Gianluca Mazzoni, Robert Moulder, Karoliina Hirvonen, Tomi Suomi, Omid Rasool, Sylvaine FA Bruggraber, M Loredana Marcovecchio, Emile Hendricks, Naba Al-Sari, Ismo Mattila, Cristina Legido-Quigley, Tommi Suvitaival, Piotr J Chmura, Mikael Knip, Anke M Schulte, Jeong Heon Lee, Guido Sebastiani, Giuseppina Emanuela Grieco, Laura L Elo, Simranjeet Kaur, Flemming Pociot, Francesco Dotta, Tim Tree, Riitta Lahesmaa, Lut Overbergh, Chantal Mathieu, Mark Peakman, Søren Brunak
BackgroundHeterogeneity in the rate of β-cell loss in newly diagnosed type 1 diabetes patients is poorly understood and creates a barrier to designing and interpreting disease-modifying clinical trials. Integrative analyses of complementary multi-om
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aed4945812f6d48199ab6c18d691d46
https://doi.org/10.1101/2023.03.22.23287261
https://doi.org/10.1101/2023.03.22.23287261
Autor:
Yuk-Fun Liu, Jake Powrie, Sefina Arif, Jennie H.M. Yang, Evangelia Williams, Leena Khatri, Mamta Joshi, Loic Lhuillier, Nikolaos Fountoulakis, Emma Smith, Craig Beam, Anna Lorenc, Mark Peakman, Timothy Tree
Publikováno v:
Diabetes. 71:722-732
Type 1 diabetes is characterized by a loss of tolerance to pancreatic β-cell autoantigens and defects in T regulatory cell (Treg) function. In preclinical models, immunotherapy with MHC-selective, autoantigenic peptides restores immune tolerance, pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b87ccec177121a6e30a6f57724a088f
https://doi.org/10.2337/db21-0728
https://doi.org/10.2337/db21-0728
Autor:
Garry Dolton, Efthalia Zervoudi, Cristina Rius, Aaron Wall, Hannah L. Thomas, Anna Fuller, Lorraine Yeo, Mateusz Legut, Sophie Wheeler, Meriem Attaf, Dmitriy M. Chudakov, Ernest Choy, Mark Peakman, Andrew K. Sewell
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Peptide–MHC (pMHC) multimers have become the “gold standard” for the detection and isolation of antigen-specific T-cells but recent evidence shows that normal use of these reagents can miss fully functional T-cells that bear T-cell receptors (T
Externí odkaz:
https://doaj.org/article/3907c5ec5dad4500be455a03cd32ba1b