Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Mark, Paetzel"'
Autor:
Jimena Pérez-Vargas, Liam J. Worrall, Andrea D. Olmstead, Anh-Tien Ton, Jaeyong Lee, Ivan Villanueva, Connor A. H. Thompson, Svenja Dudek, Siobhan Ennis, Jason R. Smith, Tirosh Shapira, Joshua De Guzman, Shutong Gang, Fuqiang Ban, Marija Vuckovic, Michael Bielecki, Suzana Kovacic, Calem Kenward, Christopher Yee Hong, Danielle G. Gordon, Paul N. Levett, Mel Krajden, Richard Leduc, Pierre-Luc Boudreault, Masahiro Niikura, Mark Paetzel, Robert N. Young, Artem Cherkasov, Natalie C. J. Strynadka, François Jean
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
Antivirals with broad coronavirus activity are important for treating high-risk individuals exposed to the constantly evolving SARS-CoV-2 variants of concern (VOCs) as well as emerging drug-resistant variants. We developed and characterized a novel c
Externí odkaz:
https://doaj.org/article/af2615cbac4f4e1583d54bc3e7ff1625
Autor:
Jaeyong Lee, Calem Kenward, Liam J. Worrall, Marija Vuckovic, Francesco Gentile, Anh-Tien Ton, Myles Ng, Artem Cherkasov, Natalie C. J. Strynadka, Mark Paetzel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The SARS-CoV-2 protease Mpro is essential for viral replication. Here, the authors have determined the structures of Mpro in complex with 10 of the 11 viral cleavage sequences including a covalent acyl-enzyme intermediate, providing mechanistic and s
Externí odkaz:
https://doaj.org/article/1bd44754c8b142a281ac22dd1d9222a1
Autor:
Jaeyong Lee, Liam J. Worrall, Marija Vuckovic, Federico I. Rosell, Francesco Gentile, Anh-Tien Ton, Nathanael A. Caveney, Fuqiang Ban, Artem Cherkasov, Mark Paetzel, Natalie C. J. Strynadka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The SARS-CoV-2 main protease (Mpro) is one of two cysteine proteases essential for viral replication. Here, the authors determine the crystal structure of an Mpro acyl intermediate with its native C-terminal autocleavage sequence and the structure of
Externí odkaz:
https://doaj.org/article/79fa01c0d7f04a9ab66a27ea9f850fb5
Autor:
J. Andrew N. Alexander, Liam J. Worrall, Jinhong Hu, Marija Vuckovic, Nidhi Satishkumar, Raymond Poon, Solmaz Sobhanifar, Federico I. Rosell, Joshua Jenkins, Daniel Chiang, Wesley A. Mosimann, Henry F. Chambers, Mark Paetzel, Som S. Chatterjee, Natalie C. J. Strynadka
Publikováno v:
Nature. 613:375-382
Broad-spectrum β-lactam antibiotic resistance in Staphylococcus aureus is a global healthcare burden1,2. In clinical strains, resistance is largely controlled by BlaR13, a receptor that senses β-lactams through the acylation of its sensor domain, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45d0f9e2d97ef3b7cab6ba9a2f4cef80
https://doi.org/10.1038/s41586-022-05583-3
https://doi.org/10.1038/s41586-022-05583-3
Autor:
Mark Paetzel
Publikováno v:
Encyclopedia of Cell Biology ISBN: 9780128216248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96896cb5be0afa0416d366545ef19adb
https://doi.org/10.1016/b978-0-12-821618-7.00273-x
https://doi.org/10.1016/b978-0-12-821618-7.00273-x
Autor:
J Andrew N, Alexander, Liam J, Worrall, Jinhong, Hu, Marija, Vuckovic, Nidhi, Satishkumar, Raymond, Poon, Solmaz, Sobhanifar, Federico I, Rosell, Joshua, Jenkins, Daniel, Chiang, Wesley A, Mosimann, Henry F, Chambers, Mark, Paetzel, Som S, Chatterjee, Natalie C J, Strynadka
Publikováno v:
Nature.
Broad-spectrum β-lactam antibiotic resistance in Staphylococcus aureus is a global healthcare burden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f21882177b02c24961cbe0329a99e638
https://pubmed.ncbi.nlm.nih.gov/36599987
https://pubmed.ncbi.nlm.nih.gov/36599987
Autor:
Liam J. Worrall, Artem Cherkasov, Francesco Gentile, Fuqiang Ban, Mark Paetzel, Jaeyong Lee, Nathanael A. Caveney, Natalie C. J. Strynadka, Marija Vuckovic, Federico I. Rosell, Anh-Tien Ton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the pathogen that causes the disease COVID-19, produces replicase polyproteins 1a and 1ab that contain, respectively, 11 or 16 nonstructural proteins (nsp). Nsp5 is the main protease (Mpro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409e58b7a4341fb45c2002da7aca1510
https://doi.org/10.1038/s41467-020-19662-4
https://doi.org/10.1038/s41467-020-19662-4
Autor:
Mark, Paetzel
Publikováno v:
Sub-cellular biochemistry. 92
Signal peptidases are the membrane bound enzymes that cleave off the amino-terminal signal peptide from secretory preproteins . There are two types of bacterial signal peptidases . Type I signal peptidase utilizes a serine/lysine catalytic dyad mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1fcb4d965101adf40c6a0bce57c0237d
https://pubmed.ncbi.nlm.nih.gov/31214988
https://pubmed.ncbi.nlm.nih.gov/31214988
Autor:
Mark Paetzel
Publikováno v:
Subcellular Biochemistry ISBN: 9783030187675
Signal peptidases are the membrane bound enzymes that cleave off the amino-terminal signal peptide from secretory preproteins . There are two types of bacterial signal peptidases . Type I signal peptidase utilizes a serine/lysine catalytic dyad mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28dbbb3cfcc72767972d4cb0fa8ec3cd
https://doi.org/10.1007/978-3-030-18768-2_7
https://doi.org/10.1007/978-3-030-18768-2_7
Autor:
Mark Paetzel, Sung-Eun Nam
Publikováno v:
Biochemistry. 52:8811-8822
Bacterial signal peptide peptidase A (SppA) is a membrane-bound enzyme that utilizes a serine/lysine catalytic dyad mechanism to cleave remnant signal peptides within the cellular membrane. Bacillus subtilis SppA (SppABS) oligomerizes into a homo-oct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb57566f0094f8884006987326166996
https://doi.org/10.1021/bi4011489
https://doi.org/10.1021/bi4011489